دورية أكاديمية
The NLRP3 inflammasome and stroke.
العنوان: | The NLRP3 inflammasome and stroke. |
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المؤلفون: | Tong Y; Hubei Center for Disease Control and Prevention Wuhan 430079, P. R. China ; School of Public Health, Tongji Medical College, Huazhong University of Science and Technology Wuhan 430030, P. R China., Ding ZH; Xiangyang Hospital of Traditional Chinese Medical Hospital Xiangyang 441021, P. R. China., Zhan FX; Hubei Center for Disease Control and Prevention Wuhan 430079, P. R. China., Cai L; Wuhan Center for Disease Control and Prevention Wuhan, 430015, P. R. China., Yin X; School of Public Health, Tongji Medical College, Huazhong University of Science and Technology Wuhan 430030, P. R China., Ling JL; Queens University Belfast Northern Ireland, United Kingdom., Ye JJ; Hubei Center for Disease Control and Prevention Wuhan 430079, P. R. China., Hou SY; Hubei Center for Disease Control and Prevention Wuhan 430079, P. R. China., Lu Z; School of Public Health, Tongji Medical College, Huazhong University of Science and Technology Wuhan 430030, P. R China., Wang ZH; Department of Neurology, Shenzhen NO. 2 People's Hospital, The First Affiliated Hospital of Shenzhen University Shenzhen 518035, P. R. China., Liu JF; Hubei Center for Disease Control and Prevention Wuhan 430079, P. R. China. |
المصدر: | International journal of clinical and experimental medicine [Int J Clin Exp Med] 2015 Apr 15; Vol. 8 (4), pp. 4787-94. Date of Electronic Publication: 2015 Apr 15 (Print Publication: 2015). |
نوع المنشور: | Journal Article; Review |
اللغة: | English |
بيانات الدورية: | Publisher: e-Century Pub. Corp Country of Publication: United States NLM ID: 101471010 Publication Model: eCollection Cited Medium: Print ISSN: 1940-5901 (Print) Linking ISSN: 19405901 NLM ISO Abbreviation: Int J Clin Exp Med Subsets: PubMed not MEDLINE |
أسماء مطبوعة: | Original Publication: Madison, WI : e-Century Pub. Corp. |
مستخلص: | Inflammasome pattern recognition receptors, which belong to the family of multi-meric proteins, play an important role in innate immunity, including NLRPs, NLRC, and NAIP. Among these receptors, NLRP3 (nucleotide-binding domain (NOD)-like receptor protein 3) inflammasome may activate the inflammation and participate in atherosclerosis, pathophysiology of myocardial infarction, resultin ischemia/reperfusion injury and stroke and other cardiovascular diseases. Effective regulation of NLRP3 may help prevent or even treat stroke. In recent years, the role of inflammation in stroke has attracted much attention, and the in-depth study of its mechanism of action is gradually clear. This mini-review focuses on the association of regulatory mechanisms of NLRP3 inflammasome with the development of stroke, which may supply some clues for future therapies and novel drug targets for stroke. |
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فهرسة مساهمة: | Keywords: NLRP3; inflammasome; inflammation; stroke |
تواريخ الأحداث: | Date Created: 20150702 Date Completed: 20150701 Latest Revision: 20201001 |
رمز التحديث: | 20221213 |
مُعرف محوري في PubMed: | PMC4483817 |
PMID: | 26131053 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1940-5901 |
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