دورية أكاديمية
أعرض في EDS

Tartrate-Resistant Acid Phosphatase 5b in Young Patients With Sickle Cell Disease and Trait Siblings: Relation to Vasculopathy and Bone Mineral Density.

التفاصيل البيبلوغرافية
العنوان: Tartrate-Resistant Acid Phosphatase 5b in Young Patients With Sickle Cell Disease and Trait Siblings: Relation to Vasculopathy and Bone Mineral Density.
المؤلفون: Mokhtar GM; Pediatrics Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt., Tantawy AA; Pediatrics Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt azatantawy@hotmail.com., Hamed AA; Pediatrics Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt., Adly AA; Pediatrics Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt., Ismail EA; Clinical Pathology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt., Makkeyah SM; Pediatrics Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
المصدر: Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis [Clin Appl Thromb Hemost] 2017 Jan; Vol. 23 (1), pp. 64-71. Date of Electronic Publication: 2015 Jul 06.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Sage Publications Country of Publication: United States NLM ID: 9508125 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1938-2723 (Electronic) Linking ISSN: 10760296 NLM ISO Abbreviation: Clin Appl Thromb Hemost Subsets: MEDLINE
أسماء مطبوعة: Publication: Thousand Oaks, CA : Sage Publications
Original Publication: New York, N.Y. : Raven Press, c1995-
مواضيع طبية MeSH: Anemia, Sickle Cell/*complications , Tartrate-Resistant Acid Phosphatase/*metabolism, Adolescent ; Anemia, Sickle Cell/mortality ; Bone Density ; Bone Resorption ; Case-Control Studies ; Child ; Child, Preschool ; Cross-Sectional Studies ; Female ; Humans ; Male ; Siblings
مستخلص: Bone involvement is a frequent cause of acute morbidity in sickle cell disease (SCD). Tartrate-resistant acid phosphatase 5b (TRACP 5b), a bone resorption marker, is produced specifically by activated osteoclasts. We assessed bone mineral density (BMD) in 30 young patients with SCD and 17 asymptomatic patients with sickle cell trait (SCT) compared with 32 healthy controls and determined TRACP 5b levels in relation to vascular complications. Serum ferritin, alkaline phosphatase (ALP), and TRACP 5b were measured. Echocardiography was performed with assessment of BMD using dual energy X-ray absorptiometry (DXA). The BMD was decreased in patients with SCD compared with SCT and controls (P = .005), with no significant difference between the latter 2 groups. Patients with SCD had higher incidence of bone complications than SCT group and controls (P = .03). The SCD group with abnormal DXA scan had higher ferritin and ALP than normal BMD. Serum TRACP 5b was significantly higher in patients with SCD than SCT and controls (P = .003). The TRACP 5b levels were associated with severe vaso-occlusive crisis (P = .022). Patients treated with hydroxyurea and those on chelation therapy had lower TRACP 5b levels than untreated patients. The TRACP 5b level was positively correlated with lactate dehydrogenase, while there was no relation with ferritin, ALP, or BMD. We suggest that bone complications frequently occur in SCD as reflected by low BMD and high ALP and TRACP 5b. Hemolysis and iron overload may be involved in the occurrence of these complications. The lack of correlation between abnormal DXA scan and high TRACP 5b suggests that bone disease in SCD is multifactorial.
(© The Author(s) 2015.)
فهرسة مساهمة: Keywords: ALP; TRACP 5b; bone mineral density; sickle cell disease; vasculopathy
المشرفين على المادة: EC 3.1.3.2 (Tartrate-Resistant Acid Phosphatase)
تواريخ الأحداث: Date Created: 20150708 Date Completed: 20170209 Latest Revision: 20170209
رمز التحديث: 20240829
DOI: 10.1177/1076029615594001
PMID: 26149452
قاعدة البيانات: MEDLINE
الوصف
تدمد:1938-2723
DOI:10.1177/1076029615594001