دورية أكاديمية
أعرض في EDS

Intergenerational neural mediators of early-life anxious temperament.

التفاصيل البيبلوغرافية
العنوان: Intergenerational neural mediators of early-life anxious temperament.
المؤلفون: Fox AS; HealthEmotions Research Institute, Department of Psychiatry, University of Wisconsin-Madison, Madison, WI 53719; Waisman Center, University of Wisconsin-Madison, Madison, WI 53705; Department of Psychiatry, University of Wisconsin-Madison, Madison, WI 53719; asfox@wisc.edu nkalin@wisc.edu., Oler JA; HealthEmotions Research Institute, Department of Psychiatry, University of Wisconsin-Madison, Madison, WI 53719; Department of Psychiatry, University of Wisconsin-Madison, Madison, WI 53719;, Shackman AJ; Department of Psychology, University of Maryland, College Park, MD 20742;, Shelton SE; HealthEmotions Research Institute, Department of Psychiatry, University of Wisconsin-Madison, Madison, WI 53719;, Raveendran M; Department of Genetics, Baylor College of Medicine, Houston, TX 77030;, McKay DR; Department of Psychiatry, Yale School of Medicine, New Haven, CT 06519;, Converse AK; Waisman Center, University of Wisconsin-Madison, Madison, WI 53705;, Alexander A; Waisman Center, University of Wisconsin-Madison, Madison, WI 53705; Department of Medical Physics, University of Wisconsin-Madison, Madison, WI 53705;, Davidson RJ; HealthEmotions Research Institute, Department of Psychiatry, University of Wisconsin-Madison, Madison, WI 53719; Waisman Center, University of Wisconsin-Madison, Madison, WI 53705; Department of Psychiatry, University of Wisconsin-Madison, Madison, WI 53719; Department of Psychology, University of Wisconsin-Madison, Madison, WI 53706;, Blangero J; Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX 78245., Rogers J; Department of Genetics, Baylor College of Medicine, Houston, TX 77030;, Kalin NH; HealthEmotions Research Institute, Department of Psychiatry, University of Wisconsin-Madison, Madison, WI 53719; Waisman Center, University of Wisconsin-Madison, Madison, WI 53705; Department of Psychiatry, University of Wisconsin-Madison, Madison, WI 53719; Department of Psychology, University of Wisconsin-Madison, Madison, WI 53706; asfox@wisc.edu nkalin@wisc.edu.
المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2015 Jul 21; Vol. 112 (29), pp. 9118-22. Date of Electronic Publication: 2015 Jul 06.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Washington, DC : National Academy of Sciences
مواضيع طبية MeSH: Family Characteristics* , Inheritance Patterns* , Temperament*, Anxiety/*physiopathology , Neurons/*physiology, Animals ; Brain/metabolism ; Brain/physiopathology ; Macaca mulatta
مستخلص: Understanding the heritability of neural systems linked to psychopathology is not sufficient to implicate them as intergenerational neural mediators. By closely examining how individual differences in neural phenotypes and psychopathology cosegregate as they fall through the family tree, we can identify the brain systems that underlie the parent-to-child transmission of psychopathology. Although research has identified genes and neural circuits that contribute to the risk of developing anxiety and depression, the specific neural systems that mediate the inborn risk for these debilitating disorders remain unknown. In a sample of 592 young rhesus monkeys that are part of an extended multigenerational pedigree, we demonstrate that metabolism within a tripartite prefrontal-limbic-midbrain circuit mediates some of the inborn risk for developing anxiety and depression. Importantly, although brain volume is highly heritable early in life, it is brain metabolism-not brain structure-that is the critical intermediary between genetics and the childhood risk to develop stress-related psychopathology.
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معلومات مُعتمدة: C06 RR020141 United States RR NCRR NIH HHS; C06 RR015459 United States RR NCRR NIH HHS; RR15459-01 United States RR NCRR NIH HHS; P30 HD003352 United States HD NICHD NIH HHS; R21 MH091550 United States MH NIMH NIH HHS; RR020141-01 United States RR NCRR NIH HHS; P50 MH084051 United States MH NIMH NIH HHS; R21 MH092581 United States MH NIMH NIH HHS; P50MH84051 United States MH NIMH NIH HHS; R21MH91550 United States MH NIMH NIH HHS; R01 MH081884 United States MH NIMH NIH HHS; R21MH092581 United States MH NIMH NIH HHS; R01 MH043454 United States MH NIMH NIH HHS; P50 MH100031 United States MH NIMH NIH HHS; P50MH100031 United States MH NIMH NIH HHS; R01MH46729 United States MH NIMH NIH HHS; P51 OD011106 United States OD NIH HHS; P51OD011106 United States OD NIH HHS; R01 MH046729 United States MH NIMH NIH HHS; R01MH81884 United States MH NIMH NIH HHS
فهرسة مساهمة: Keywords: anxiety; brain volume; heritability; positron emission tomography; primate
تواريخ الأحداث: Date Created: 20150708 Date Completed: 20151013 Latest Revision: 20181113
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC4517228
DOI: 10.1073/pnas.1508593112
PMID: 26150480
قاعدة البيانات: MEDLINE
الوصف
تدمد:1091-6490
DOI:10.1073/pnas.1508593112