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Obesity and survival among women with ovarian cancer: results from the Ovarian Cancer Association Consortium.

التفاصيل البيبلوغرافية
العنوان: Obesity and survival among women with ovarian cancer: results from the Ovarian Cancer Association Consortium.
المؤلفون: Nagle CM; Population Health Department, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia., Dixon SC; Population Health Department, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.; School of Population Health, University of Queensland, Brisbane, QLD, Australia., Jensen A; Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark., Kjaer SK; Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark.; Department of Gynecology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark., Modugno F; Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pennsylvania, PA, USA.; Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pennsylvania, PA, USA.; Womens Cancer Research Program, Magee-Womens Research Institute and University of Pittsburgh Cancer Institute, Pennsylvania, PA, USA., deFazio A; Department of Gynaecological Oncology, Westmead Hospital, Westmead, NSW, Australia.; Center for Cancer Research, University of Sydney at the Westmead Millennium Institute, Westmead, NSW, Australia., Fereday S; Peter MacCallum Cancer Centre, East Melbourne, VIC, Australia., Hung J; Department of Gynaecological Oncology, Westmead Hospital, Westmead, NSW, Australia.; Center for Cancer Research, University of Sydney at the Westmead Millennium Institute, Westmead, NSW, Australia., Johnatty SE; Genetics and Computational Biology Department, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia., Fasching PA; David Geffen School of Medicine, Department of Medicine Division of Hematology and Oncology, University of California at Los Angeles, Los Angeles, CA, USA.; Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany., Beckmann MW; Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany., Lambrechts D; Vesalius Research Center, VIB, Leuven, Belgium.; Department of Oncology, University of Leuven, Leuven, Belgium., Vergote I; Department of Obstetrics and Gynecology, Leuven Cancer Institute, University Hospitals Leuven, Leuven, Belgium., Van Nieuwenhuysen E; Department of Obstetrics and Gynecology, Leuven Cancer Institute, University Hospitals Leuven, Leuven, Belgium., Lambrechts S; Department of Obstetrics and Gynecology, Leuven Cancer Institute, University Hospitals Leuven, Leuven, Belgium., Risch HA; Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, CT, USA., Rossing MA; Program in Epidemiology, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Doherty JA; Department of Community and Family Medicine, The Geisel School of Medicine at Dartmouth, Lebanon, NH, USA., Wicklund KG; Program in Epidemiology, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Chang-Claude J; Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany., Goodman MT; Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Ness RB; School of Public Health, University of Texas, Houston, TX, USA., Moysich K; Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY, USA., Heitz F; Department of Gynecology and Gynecologic Oncology, Kliniken Essen-Mitte/Evang. Huyssens-Stiftung/Knappschaft GmbH, Essen, Germany.; Department of Gynecology and Gynecologic Oncology, Dr Horst Schmidt Kliniken Wiesbaden, Wiesbaden, Germany., du Bois A; Department of Gynecology and Gynecologic Oncology, Kliniken Essen-Mitte/Evang. Huyssens-Stiftung/Knappschaft GmbH, Essen, Germany.; Department of Gynecology and Gynecologic Oncology, Dr Horst Schmidt Kliniken Wiesbaden, Wiesbaden, Germany., Harter P; Department of Gynecology and Gynecologic Oncology, Kliniken Essen-Mitte/Evang. Huyssens-Stiftung/Knappschaft GmbH, Essen, Germany.; Department of Gynecology and Gynecologic Oncology, Dr Horst Schmidt Kliniken Wiesbaden, Wiesbaden, Germany., Schwaab I; Institut für Humangenetik Wiesbaden, Wiesbaden, Germany., Matsuo K; Department of Preventive Medicine, Faculty of Medical Sciences, Kyushu University, Nagoya, Aichi, Japan., Hosono S; Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Aichi, Japan., Goode EL; Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA., Vierkant RA; Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA., Larson MC; Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA., Fridley BL; Department of Biostatistics, University of Kansas, Kansas City, KS, USA., Høgdall C; Department of Gynecology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark., Schildkraut JM; Department of Community and Family Medicine, Duke University Medical Center, Durham, NC, USA., Weber RP; Department of Community and Family Medicine, Duke University Medical Center, Durham, NC, USA., Cramer DW; Obstetrics and Gynecology Epidemiology Center, Brigham and Women's Hospital, Boston, MA, USA., Terry KL; Obstetrics and Gynecology Epidemiology Center, Brigham and Women's Hospital, Boston, MA, USA., Bandera EV; Rutgers Cancer Institute of New Jersey, Robert Wood Johnson Medical School, New Brunswick, NJ, USA., Paddock L; New Jersey State Cancer Registry, Trenton, NJ, USA., Rodriguez-Rodriguez L; Rutgers Cancer Institute of New Jersey, Robert Wood Johnson Medical School, New Brunswick, NJ, USA., Wentzensen N; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Yang HP; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Brinton LA; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Lissowska J; Department of Cancer Epidemiology and Prevention, M. Sklodowska-Curie Cancer Center, Warsaw, Poland., Høgdall E; Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark.; Molecular Unit, Department of Pathology, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark., Lundvall L; Department of Gynecology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark., Whittemore A; Department of Health Research and Policy-Epidemiology, Stanford University School of Medicine, Stanford, CA, USA., McGuire V; Department of Health Research and Policy-Epidemiology, Stanford University School of Medicine, Stanford, CA, USA., Sieh W; Department of Health Research and Policy-Epidemiology, Stanford University School of Medicine, Stanford, CA, USA., Rothstein J; Department of Health Research and Policy-Epidemiology, Stanford University School of Medicine, Stanford, CA, USA., Sutphen R; Epidemiology Center, College of Medicine, University of South Florida, Tampa, FL, USA., Anton-Culver H; Department of Epidemiology, School of Medicine, University of California Irvine, Irvine, California, USA., Ziogas A; Department of Epidemiology, School of Medicine, University of California Irvine, Irvine, California, USA., Pearce CL; Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA, USA., Wu AH; Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA, USA., Webb PM; Population Health Department, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.; School of Population Health, University of Queensland, Brisbane, QLD, Australia.
مؤلفون مشاركون: Australian Ovarian Cancer Study Group, Ovarian Cancer Association Consortium
المصدر: British journal of cancer [Br J Cancer] 2015 Sep 01; Vol. 113 (5), pp. 817-26. Date of Electronic Publication: 2015 Jul 07.
نوع المنشور: Journal Article; Meta-Analysis; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group on behalf of Cancer Research UK Country of Publication: England NLM ID: 0370635 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-1827 (Electronic) Linking ISSN: 00070920 NLM ISO Abbreviation: Br J Cancer Subsets: MEDLINE
أسماء مطبوعة: Publication: 2002- : London : Nature Publishing Group on behalf of Cancer Research UK
Original Publication: London, Lewis.
مواضيع طبية MeSH: Neoplasms, Glandular and Epithelial/*pathology , Obesity/*pathology , Ovarian Neoplasms/*pathology, Body Mass Index ; Carcinoma, Ovarian Epithelial ; Disease-Free Survival ; Female ; Humans ; Kaplan-Meier Estimate ; Neoplasms, Glandular and Epithelial/mortality ; Obesity/mortality ; Ovarian Neoplasms/mortality
مستخلص: Background: Observational studies have reported a modest association between obesity and risk of ovarian cancer; however, whether it is also associated with survival and whether this association varies for the different histologic subtypes are not clear. We undertook an international collaborative analysis to assess the association between body mass index (BMI), assessed shortly before diagnosis, progression-free survival (PFS), ovarian cancer-specific survival and overall survival (OS) among women with invasive ovarian cancer.
Methods: We used original data from 21 studies, which included 12 390 women with ovarian carcinoma. We combined study-specific adjusted hazard ratios (HRs) using random-effects models to estimate pooled HRs (pHR). We further explored associations by histologic subtype.
Results: Overall, 6715 (54%) deaths occurred during follow-up. A significant OS disadvantage was observed for women who were obese (BMI: 30-34.9, pHR: 1.10 (95% confidence intervals (CIs): 0.99-1.23); BMI: ⩾35, pHR: 1.12 (95% CI: 1.01-1.25)). Results were similar for PFS and ovarian cancer-specific survival. In analyses stratified by histologic subtype, associations were strongest for women with low-grade serous (pHR: 1.12 per 5 kg m(-2)) and endometrioid subtypes (pHR: 1.08 per 5 kg m(-2)), and more modest for the high-grade serous (pHR: 1.04 per 5 kg m(-2)) subtype, but only the association with high-grade serous cancers was significant.
Conclusions: Higher BMI is associated with adverse survival among the majority of women with ovarian cancer.
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معلومات مُعتمدة: R03-CA115195 United States CA NCI NIH HHS; R01-CA61107 United States CA NCI NIH HHS; R01-CA054419 United States CA NCI NIH HHS; P50 CA105009 United States CA NCI NIH HHS; R01-CA95023 United States CA NCI NIH HHS; R03 CA115195 United States CA NCI NIH HHS; P01 CA017054 United States CA NCI NIH HHS; U01 CA069417 United States CA NCI NIH HHS; P01-CA17054 United States CA NCI NIH HHS; N01 CN025403 United States CN NCI NIH HHS; P50-CA159981 United States CA NCI NIH HHS; P50 CA159981 United States CA NCI NIH HHS; P30 CA016056 United States CA NCI NIH HHS; R01 CA087538 United States CA NCI NIH HHS; N01-PC-67001 United States PC NCI NIH HHS; K22-CA138563 United States CA NCI NIH HHS; R01 CA106414 United States CA NCI NIH HHS; M01 RR000056 United States RR NCRR NIH HHS; P30 CA072720 United States CA NCI NIH HHS; R01 CA095023 United States CA NCI NIH HHS; MO1-RR000056 United States RR NCRR NIH HHS; R03-CA113148 United States CA NCI NIH HHS; U01-CA69417 United States CA NCI NIH HHS; R01-CA112523 United States CA NCI NIH HHS; R03 CA113148 United States CA NCI NIH HHS; R01 CA058598 United States CA NCI NIH HHS; R01-CA080742 United States CA NCI NIH HHS; K22 CA138563 United States CA NCI NIH HHS; R01-CA106414 United States CA NCI NIH HHS; R01 CA058860 United States CA NCI NIH HHS; R01 CA080742 United States CA NCI NIH HHS; P30-CA072720 United States CA NCI NIH HHS; R01-CA126841 United States CA NCI NIH HHS; R01-CA058598 United States CA NCI NIH HHS; R01 CA074850 United States CA NCI NIH HHS; R01-CA122443 United States CA NCI NIH HHS; R01CA058860 United States CA NCI NIH HHS; K07 CA092044 United States CA NCI NIH HHS; R01-CA087538 United States CA NCI NIH HHS; K07 CA080668 United States CA NCI NIH HHS; R01-CA074850 United States CA NCI NIH HHS; U01-CA71966 United States CA NCI NIH HHS; P50-CA105009 United States CA NCI NIH HHS; R01 CA083918 United States CA NCI NIH HHS; N01-CN-55424 United States CN NCI NIH HHS; R01-CA83918 United States CA NCI NIH HHS; R01 CA054419 United States CA NCI NIH HHS; R01 CA122443 United States CA NCI NIH HHS; P30 CA015083 United States CA NCI NIH HHS; R01-CA016056 United States CA NCI NIH HHS; R01 CA076016 United States CA NCI NIH HHS; R01 CA092044 United States CA NCI NIH HHS; K07 CA143047 United States CA NCI NIH HHS; K07-CA143047 United States CA NCI NIH HHS; K07-CA095666 United States CA NCI NIH HHS; R01-CA076016 United States CA NCI NIH HHS; K07-CA080668 United States CA NCI NIH HHS; P50-CA136393 United States CA NCI NIH HHS; K07 CA095666 United States CA NCI NIH HHS; R01 CA112523 United States CA NCI NIH HHS; P50 CA136393 United States CA NCI NIH HHS; R01 CA126841 United States CA NCI NIH HHS; P30-CA15083 United States CA NCI NIH HHS
فهرسة مساهمة: Investigator: D Bowtell; G Chenevix-Trench; A deFazio; D Gertig; A Green; PM Webb; A Green; P Parsons; N Hayward; PM Webb; D Whiteman
تواريخ الأحداث: Date Created: 20150708 Date Completed: 20151123 Latest Revision: 20240615
رمز التحديث: 20240615
مُعرف محوري في PubMed: PMC4559823
DOI: 10.1038/bjc.2015.245
PMID: 26151456
قاعدة البيانات: MEDLINE
الوصف
تدمد:1532-1827
DOI:10.1038/bjc.2015.245