دورية أكاديمية
Sarcoidosis-related hypercalcaemia due to production of parathyroid hormone-related peptide.
| العنوان: | Sarcoidosis-related hypercalcaemia due to production of parathyroid hormone-related peptide. |
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| المؤلفون: | van Raalte DH; Department of Internal Medicine, Kennemer Gasthuis, Haarlem, The Netherlands., Goorden SM; Atal Medial Diagnostic Centers, Hoofddorp, The Netherlands., Kemper EA; Department of Clinical Chemistry, IJsselland Hospital, Capelle aan den IJssel, The Netherlands., Brosens LA; Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands., ten Kate RW; Department of Internal Medicine, Kennemer Gasthuis, Haarlem, The Netherlands. |
| المصدر: | BMJ case reports [BMJ Case Rep] 2015 Jul 09; Vol. 2015. Date of Electronic Publication: 2015 Jul 09. |
| نوع المنشور: | Case Reports; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: BMJ Pub. Group Country of Publication: England NLM ID: 101526291 Publication Model: Electronic Cited Medium: Internet ISSN: 1757-790X (Electronic) Linking ISSN: 1757790X NLM ISO Abbreviation: BMJ Case Rep Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: London : BMJ Pub. Group |
| مواضيع طبية MeSH: | Bone Marrow/*pathology , Hypercalcemia/*etiology , Parathyroid Hormone/*blood , Parathyroid Hormone-Related Protein/*blood , Sarcoidosis/*complications , Vitamin D/*blood, Aged ; Granuloma/complications ; Humans ; Hypercalcemia/drug therapy ; Male ; Prednisolone/therapeutic use |
| مستخلص: | Hypercalcaemia is frequently observed in patients with sarcoidosis. This is classically attributed to ectopic production of 1,25 dihydroxy vitamin D by sarcoid granulomas. We present a case of sarcoidosis-related hypercalcaemia with normal vitamin D levels. In this patient, production of parathyroid hormone-related peptide (PTHrp) was the cause for sarcoidosis-induced hypercalcaemia. As such, plasma PTHrp levels were increased and bone marrow granulomas stained positively for PTHrp expression. Medium-dose prednisolone treatment improved symptoms of sarcoidosis and normalised serum calcium, and PTHrp concentrations. Thus, production of PTHrp may be the cause for hypercalcaemia in some patients with sarcoidosis. (2015 BMJ Publishing Group Ltd.) |
| التعليقات: | Erratum in: BMJ Case Rep. 2015;2015. pii: bcr2015210189corr1. doi: 10.1136/bcr-2015-210189corr1. (PMID: 26370637) |
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| المشرفين على المادة: | 0 (PTHLH protein, human) 0 (Parathyroid Hormone) 0 (Parathyroid Hormone-Related Protein) 1406-16-2 (Vitamin D) 9PHQ9Y1OLM (Prednisolone) |
| تواريخ الأحداث: | Date Created: 20150711 Date Completed: 20160407 Latest Revision: 20190201 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC4499713 |
| DOI: | 10.1136/bcr-2015-210189 |
| PMID: | 26160550 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1757-790X |
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| DOI: | 10.1136/bcr-2015-210189 |