دورية أكاديمية
أعرض في EDS

Aurora A Kinase Contributes to a Pole-Based Error Correction Pathway.

التفاصيل البيبلوغرافية
العنوان: Aurora A Kinase Contributes to a Pole-Based Error Correction Pathway.
المؤلفون: Ye AA; Biology Department, University of Massachusetts Amherst, Amherst, MA 01003, USA; Molecular and Cellular Biology Graduate Program, University of Massachusetts Amherst, Amherst, MA 01003, USA., Deretic J; Wellcome Trust Centre for Cell Biology, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JR, UK., Hoel CM; Biology Department, University of Massachusetts Amherst, Amherst, MA 01003, USA., Hinman AW; Department of Biological Sciences and Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, VA 24061, USA., Cimini D; Department of Biological Sciences and Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, VA 24061, USA., Welburn JP; Wellcome Trust Centre for Cell Biology, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JR, UK., Maresca TJ; Biology Department, University of Massachusetts Amherst, Amherst, MA 01003, USA; Molecular and Cellular Biology Graduate Program, University of Massachusetts Amherst, Amherst, MA 01003, USA. Electronic address: tmaresca@bio.umass.edu.
المصدر: Current biology : CB [Curr Biol] 2015 Jul 20; Vol. 25 (14), pp. 1842-51. Date of Electronic Publication: 2015 Jul 09.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
اللغة: English
بيانات الدورية: Publisher: Cell Press Country of Publication: England NLM ID: 9107782 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0445 (Electronic) Linking ISSN: 09609822 NLM ISO Abbreviation: Curr Biol Subsets: MEDLINE
أسماء مطبوعة: Publication: Cambridge, MA : Cell Press
Original Publication: London, UK : Current Biology Ltd., c1991-
مواضيع طبية MeSH: Cell Polarity* , Chromosome Positioning*, Aurora Kinase A/*genetics , Chromosomes, Insect/*metabolism , Drosophila Proteins/*genetics , Drosophila melanogaster/*genetics, Animals ; Aurora Kinase A/metabolism ; Cells, Cultured ; Chromosomes, Insect/ultrastructure ; Drosophila Proteins/metabolism ; Drosophila melanogaster/metabolism ; Drosophila melanogaster/ultrastructure ; Gene Expression Regulation ; Kinetochores/metabolism ; Kinetochores/ultrastructure ; Microtubules/metabolism ; Microtubules/ultrastructure
مستخلص: Chromosome biorientation, where sister kinetochores attach to microtubules (MTs) from opposing spindle poles, is the configuration that best ensures equal partitioning of the genome during cell division. Erroneous kinetochore-MT attachments are commonplace but are often corrected prior to anaphase. Error correction, thought to be mediated primarily by the centromere-enriched Aurora B kinase (ABK), typically occurs near spindle poles; however, the relevance of this locale is unclear. Furthermore, polar ejection forces (PEFs), highest near poles, can stabilize improper attachments by pushing mal-oriented chromosome arms away from spindle poles. Hence, there is a conundrum: erroneous kinetochore-MT attachments are weakened where PEFs are most likely to strengthen them. Here, we report that Aurora A kinase (AAK) opposes the stabilizing effect of PEFs. AAK activity contributes to phosphorylation of kinetochore substrates near poles and its inhibition results in chromosome misalignment and an increased incidence of erroneous kinetochore-MT attachments. Furthermore, AAK directly phosphorylates a site in the N-terminal tail of Ndc80/Hec1 that has been implicated in reducing the affinity of the Ndc80 complex for MTs when phosphorylated. We propose that an AAK activity gradient contributes to correcting mal-oriented kinetochore-MT attachments in the vicinity of spindle poles.
(Copyright © 2015 Elsevier Ltd. All rights reserved.)
التعليقات: Comment in: Curr Biol. 2015 Jul 20;25(14):R601-3. (PMID: 26196485)
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معلومات مُعتمدة: 12840 United Kingdom CRUK_ Cancer Research UK; R01 GM107026 United States GM NIGMS NIH HHS; C40377/A12840 United Kingdom CRUK_ Cancer Research UK; 5 R01 GM107026 United States GM NIGMS NIH HHS
المشرفين على المادة: 0 (Drosophila Proteins)
EC 2.7.11.1 (Aurora Kinase A)
EC 2.7.11.1 (aurA protein, Drosophila)
تواريخ الأحداث: Date Created: 20150714 Date Completed: 20160418 Latest Revision: 20220129
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC4509859
DOI: 10.1016/j.cub.2015.06.021
PMID: 26166783
قاعدة البيانات: MEDLINE
الوصف
تدمد:1879-0445
DOI:10.1016/j.cub.2015.06.021