دورية أكاديمية

Sentinel lymph node biopsy in bladder cancer: Systematic review and technology update.

التفاصيل البيبلوغرافية
العنوان: Sentinel lymph node biopsy in bladder cancer: Systematic review and technology update.
المؤلفون: Liss MA; Department of Urology, University of Texas Health Science Center, San Antonio, TX, United States., Noguchi J; Department of Urology, University of California, San Diego, California, United States., Lee HJ; Department of Urology, University of California, San Diego, California, United States., Vera DR; Department of Radiology and Surgery, University of California, San Diego, California, United States., Kader AK; Department of Urology, University of California, San Diego, California, United States.
المصدر: Indian journal of urology : IJU : journal of the Urological Society of India [Indian J Urol] 2015 Jul-Sep; Vol. 31 (3), pp. 170-5.
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: Medknow Publications Country of Publication: India NLM ID: 8510441 Publication Model: Print Cited Medium: Print ISSN: 0970-1591 (Print) Linking ISSN: 09701591 NLM ISO Abbreviation: Indian J Urol Subsets: PubMed not MEDLINE
أسماء مطبوعة: Publication: Mumbai : Medknow Publications
Original Publication: Hyderabad, A.P. : Urological Society of India, [1984-
مستخلص: A sentinel lymph node (SLN) is the first lymph node to drain a solid tumor and likely the first place metastasis will travel. SLN biopsy has been well established as a staging tool for melanoma and breast cancer to guide lymph node dissection (LND); its utility in bladder cancer is debated. We performed a systematic search of PubMed for both human and animal studies that looked at SLN detection in cases of urothelial carcinoma of the bladder. We identified a total of nine studies that assessed a variety of imaging techniques to identify SLNs in patients with urothelial carcinoma of the bladder. Eight studies investigated human patients while one looked at animal (dog) models. Seven studies representing 156 patients noted the negative predictive value of the SLN to predict a metastasis free state was 92% (92/100). The SLN biopsy was less accurate in metastatic patients with a positive predictive value of only 77% (43/56) with a false negative range of in individual studies of 0-19%. Clinically, positive nodes routinely do not take up the pharmaceutical agent for SLN. Therefore, SLN biopsy is a promising concept with a 92% negative predictive value; however, the false negative rates are high which may be improved by standardizing populations and indications. Novel technologies are improving the detection of SLN and may provide the surgeon with an improved ability to detect micrometastasis, guide surgery, and reduce patient morbidity.
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فهرسة مساهمة: Keywords: Bladder cancer; radiology; sentinel lymph node; technology
تواريخ الأحداث: Date Created: 20150714 Date Completed: 20150713 Latest Revision: 20201001
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC4495490
DOI: 10.4103/0970-1591.159601
PMID: 26166959
قاعدة البيانات: MEDLINE
الوصف
تدمد:0970-1591
DOI:10.4103/0970-1591.159601