دورية أكاديمية
Lessons learnt from the management of a case of Lassa fever and follow-up of nosocomial primary contacts in Nigeria during Ebola virus disease outbreak in West Africa.
| العنوان: | Lessons learnt from the management of a case of Lassa fever and follow-up of nosocomial primary contacts in Nigeria during Ebola virus disease outbreak in West Africa. |
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| المؤلفون: | Iroezindu MO; Department of Medicine, University of Nigeria Teaching Hospital, Ituku/Ozalla, Enugu, Nigeria., Unigwe US; Department of Medicine, University of Nigeria Teaching Hospital, Ituku/Ozalla, Enugu, Nigeria., Okwara CC; Department of Medicine, University of Nigeria Teaching Hospital, Ituku/Ozalla, Enugu, Nigeria., Ozoh GA; Department of Medicine, University of Nigeria Teaching Hospital, Ituku/Ozalla, Enugu, Nigeria., Ndu AC; Department of Community Medicine, University of Nigeria Teaching Hospital, Ituku/Ozalla, Enugu, Nigeria., Ohanu ME; Department of Medical Microbiology, University of Nigeria Teaching Hospital, Ituku/Ozalla, Enugu, Nigeria., Nwoko UO; Department of Medicine, University of Nigeria Teaching Hospital, Ituku/Ozalla, Enugu, Nigeria., Okoroafor UW; Department of Medicine, University of Nigeria Teaching Hospital, Ituku/Ozalla, Enugu, Nigeria., Ejimudo E; Nigeria Centre for Disease Control and Prevention, Abuja, Nigeria., Tobin EA; Institute of Lassa Fever Research and Control, Irrua Specialist Hospital, Irrua, Edo State, Nigeria., Asogun DA; Institute of Lassa Fever Research and Control, Irrua Specialist Hospital, Irrua, Edo State, Nigeria. |
| المصدر: | Tropical medicine & international health : TM & IH [Trop Med Int Health] 2015 Nov; Vol. 20 (11), pp. 1424-1430. Date of Electronic Publication: 2015 Jul 24. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Blackwell Scientific Publications Country of Publication: England NLM ID: 9610576 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-3156 (Electronic) Linking ISSN: 13602276 NLM ISO Abbreviation: Trop Med Int Health |
| أسماء مطبوعة: | Publication: Oxford : Blackwell Scientific Publications Original Publication: Oxford, UK : Blackwell Science Ltd, c1996- |
| مستخلص: | Objective: To describe our experiences in the management of a case of Lassa fever (LF) and follow-up of nosocomial primary contacts during the 2014 Ebola outbreak in West Africa. Methods: Clinical management of the index case and infection control/surveillance activities for primary contacts are described. Laboratory confirmation was by Lassa virus-specific reverse-transcriptase PCR. Results: A 28-year-old man with a 10-day history of febrile illness was referred to a major tertiary hospital in south-east Nigeria from a city that previously experienced a LF outbreak and was recently affected by Ebola. On observation of haemorrhagic features, clinicians were at a crossroads. Diagnosis of LF was confirmed at a National Reference Centre. The patient died despite initiation of ribavirin therapy. Response activities identified 121 primary contacts comprising 78 (64.5%) hospital staff/interns, 19 (15.7%) medical students, 18 (14.9%) inpatients and 6 (5.0%) relatives. Their mean age was 32.8 ± 6.6 years, and 65.3% were women. Twenty (16.5%) had high-risk exposure and were offered ribavirin as post-exposure prophylaxis. No secondary case of LF occurred. Fatigue (43.8%) and dizziness (31.3%) were the commonest side effects of ribavirin. Conclusions: Response activities contained nosocomial spread of LF, but challenges were experienced including lack of a purpose-built isolation facility, absence of local Lassa virus laboratory capacity, failure to use appropriate protective equipment and stigmatisation of contacts. A key lesson is that the weak health systems of Africa should be comprehensively strengthened; otherwise, we might win the Ebola battle but lose the one against less virulent infections for which effective treatment exists. (© 2015 John Wiley & Sons Ltd.) |
| فهرسة مساهمة: | Keywords: Ebola; Fiebre de Lassa; Lassa fever; contactos primarios; fièvre de Lassa; lecciones; lessons; leçons; premier contact; primary contact; surveillance; vigilancia; Ébola |
| تواريخ الأحداث: | Date Created: 20150715 Latest Revision: 20220321 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1111/tmi.12565 |
| PMID: | 26171669 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1365-3156 |
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| DOI: | 10.1111/tmi.12565 |