دورية أكاديمية
Toxicity study in blood and tumor cells of laser produced medicines for application in fabrics.
| العنوان: | Toxicity study in blood and tumor cells of laser produced medicines for application in fabrics. |
|---|---|
| المؤلفون: | Morán MC; Departament de Fisiologia, Facultat de Farmàcia, Universitat de Barcelona, Avda. Joan XXIII s/n, 08028 Barcelona, Spain; Institut de Nanociència i Nanotecnologia-IN(2)UB, Universitat de Barcelona, Avda. Joan XXIII s/n, 08028 Barcelona, Spain. Electronic address: mcmoranb@ub.edu., Tozar T; National Institute for Laser, Plasma and Radiation Physics, 077125 Magurele, Romania; Faculty of Physics, University of Bucharest, 077125 Magurele, Romania., Simon A; National Institute for Laser, Plasma and Radiation Physics, 077125 Magurele, Romania; Faculty of Physics, University of Bucharest, 077125 Magurele, Romania., Dinache A; National Institute for Laser, Plasma and Radiation Physics, 077125 Magurele, Romania; Faculty of Physics, University of Bucharest, 077125 Magurele, Romania., Smarandache A; National Institute for Laser, Plasma and Radiation Physics, 077125 Magurele, Romania; Faculty of Physics, University of Bucharest, 077125 Magurele, Romania., Andrei IR; National Institute for Laser, Plasma and Radiation Physics, 077125 Magurele, Romania., Boni M; National Institute for Laser, Plasma and Radiation Physics, 077125 Magurele, Romania; Faculty of Physics, University of Bucharest, 077125 Magurele, Romania., Pascu ML; National Institute for Laser, Plasma and Radiation Physics, 077125 Magurele, Romania; Faculty of Physics, University of Bucharest, 077125 Magurele, Romania., Cirisano F; CNR - Istituto per l' Energetica e le Interfasi, 16149 Genova, Italy., Ferrari M; CNR - Istituto per l' Energetica e le Interfasi, 16149 Genova, Italy. |
| المصدر: | Colloids and surfaces. B, Biointerfaces [Colloids Surf B Biointerfaces] 2016 Jan 01; Vol. 137, pp. 91-103. Date of Electronic Publication: 2015 Jun 26. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 9315133 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4367 (Electronic) Linking ISSN: 09277765 NLM ISO Abbreviation: Colloids Surf B Biointerfaces Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam ; New York : Elsevier, c1993- |
| مواضيع طبية MeSH: | Lasers* , Textiles*, Phenothiazines/*toxicity, 3T3 Cells ; Animals ; Erythrocytes/drug effects ; Hemolysis/drug effects ; Humans ; Mice ; Phenothiazines/administration & dosage |
| مستخلص: | Phenothiazine derivatives are non-antibiotics with antimicrobial, fungistatic and fungicidal effects. We exposed to a high energy UV laser beam phenothiazines solutions in water at 20mg/mL concentration to increase antibacterial activity of resulting mixtures. Compared to previous results obtained on bacteria, more research is needed about UV laser irradiated phenothiazines applications on cancer cell cultures to evidence possible anticancerous properties. Evaluation of the safety of the newly obtained photoproducts in view of use on humans is also needed. Due to expensive animal testing in toxicology and pressure from general public and governments to develop alternatives to in vivo testing, in vitro cell-based models are attractive for preliminary testing of new materials. Cytotoxicity screening reported here shows that laser irradiated (4h exposure time length) chlorpromazine and promazine are more efficient against some cell cultures. Interaction of laser irradiated phenothiazines with fabrics show that promethazine and chlorpromazine have improved wetting properties. Correlation of these two groups of properties shows that chlorpromazine appears to be more recommended for applications on tissues using fabrics as transport vectors. The reported results concern stability study of phenothiazines water solutions to know the time limits within which they are stable and may be used. (Copyright © 2015 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Culture cells; Fabrics; Hemolysis; In vitro cytotoxicity; Laser; Phenothiazines |
| المشرفين على المادة: | 0 (Phenothiazines) |
| تواريخ الأحداث: | Date Created: 20150719 Date Completed: 20161019 Latest Revision: 20161230 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.colsurfb.2015.06.041 |
| PMID: | 26187648 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1873-4367 |
|---|---|
| DOI: | 10.1016/j.colsurfb.2015.06.041 |