دورية أكاديمية
Baccharis dracunculifolia methanol extract enhances glucose-stimulated insulin secretion in pancreatic islets of monosodium glutamate induced-obesity model rats.
| العنوان: | Baccharis dracunculifolia methanol extract enhances glucose-stimulated insulin secretion in pancreatic islets of monosodium glutamate induced-obesity model rats. |
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| المؤلفون: | Hocayen Pde A; a Department of General Biology , Ponta Grossa State University , Ponta Grossa , Paraná , Brazil ., Grassiolli S; a Department of General Biology , Ponta Grossa State University , Ponta Grossa , Paraná , Brazil ., Leite NC; a Department of General Biology , Ponta Grossa State University , Ponta Grossa , Paraná , Brazil ., Pochapski MT; a Department of General Biology , Ponta Grossa State University , Ponta Grossa , Paraná , Brazil ., Pereira RA; b Department of General Biology , Midwest State University of Paraná , Guarapuava , Paraná , Brazil , and., da Silva LA; b Department of General Biology , Midwest State University of Paraná , Guarapuava , Paraná , Brazil , and., Snack AL; b Department of General Biology , Midwest State University of Paraná , Guarapuava , Paraná , Brazil , and., Michel RG; b Department of General Biology , Midwest State University of Paraná , Guarapuava , Paraná , Brazil , and., Kagimura FY; c Chemical Department , Federal Technological University of Paraná , Pato Branco , PR , Brazil., da Cunha MA; c Chemical Department , Federal Technological University of Paraná , Pato Branco , PR , Brazil., Malfatti CR; b Department of General Biology , Midwest State University of Paraná , Guarapuava , Paraná , Brazil , and. |
| المصدر: | Pharmaceutical biology [Pharm Biol] 2016 Jul; Vol. 54 (7), pp. 1263-71. Date of Electronic Publication: 2015 Jul 21. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Taylor & Francis Country of Publication: England NLM ID: 9812552 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1744-5116 (Electronic) Linking ISSN: 13880209 NLM ISO Abbreviation: Pharm Biol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: [London] : Taylor & Francis Original Publication: Lisse, the Netherlands : Swets & Zeitlinger, c1998- |
| مواضيع طبية MeSH: | Baccharis*/chemistry , Sodium Glutamate*, Anti-Obesity Agents/*pharmacology , Blood Glucose/*drug effects , Hypoglycemic Agents/*pharmacology , Insulin/*metabolism , Islets of Langerhans/*drug effects , Methanol/*chemistry , Obesity/*drug therapy , Plant Extracts/*pharmacology , Solvents/*chemistry, Animals ; Animals, Newborn ; Anti-Obesity Agents/isolation & purification ; Antioxidants/isolation & purification ; Antioxidants/pharmacology ; Blood Glucose/metabolism ; Disease Models, Animal ; Hypoglycemic Agents/isolation & purification ; Insulin Resistance ; Insulin Secretion ; Islets of Langerhans/metabolism ; Male ; Obesity/chemically induced ; Obesity/metabolism ; Obesity/physiopathology ; Phytotherapy ; Plant Extracts/isolation & purification ; Plants, Medicinal ; Rats, Wistar ; Time Factors |
| مستخلص: | Context: Obesity is the main risk factor for type 2 diabetes mellitus. Secondary metabolites with biological activities and pharmacological potential have been identified in species of the Baccharis genus that are specifically distributed in the Americas. Objective: This study evaluated the effects of methanol extracts from Baccharis dracunculifolia DC. Asteraceae on metabolic parameters, satiety, and growth in monosodium glutamate (MSG) induced-obesity model rats. Materials and Methods: MSG was administered to 32 newborn rats (4 mg/g of body weight) once daily for 5 consecutive days. Four experimental groups (control, control + extract, MSG, and MSG + extract) were treated for 30 consecutive days with 400 mg/kg of B. dracunculifolia extract by gavage. Biochemical parameters, antioxidant activity, total extract phenolic content (methanolic, ethanolic, and acetone extractions), and pancreatic islets were evaluated. Results: High levels of phenolic compounds were identified in B. dracunculifolia extracts (methanol: 46.2 ± 0.4 mg GAE/L; acetate: 70.5 ± 0.5 mg GAE/L; and ethanol: 30.3 ± 0.21 mg GAE/L); high antioxidant activity was detected in B. dracunculifolia ethanol and methanol extracts. The concentration of serum insulin increased 30% in obese animals treated with extract solutions (1.4-2.0 µU/mL, p < 0.05). Insulin secretion in pancreatic islets was 8.3 mM glucose (58%, p < 0.05) and 16.7 mM (99.5%, p < 0.05) in rats in the MSG + extract and MSG groups, respectively. Discussion and Conclusion: Treatment with B. dracunculifolia extracts protected pancreatic islets and prevented the irreversible cellular damage observed in animals in obesity and diabetes models. |
| فهرسة مساهمة: | Keywords: metabolism; phenolic compounds; β Cells |
| المشرفين على المادة: | 0 (Anti-Obesity Agents) 0 (Antioxidants) 0 (Blood Glucose) 0 (Hypoglycemic Agents) 0 (Insulin) 0 (Plant Extracts) 0 (Solvents) W81N5U6R6U (Sodium Glutamate) Y4S76JWI15 (Methanol) |
| تواريخ الأحداث: | Date Created: 20150722 Date Completed: 20170207 Latest Revision: 20181217 |
| رمز التحديث: | 20221213 |
| DOI: | 10.3109/13880209.2015.1067232 |
| PMID: | 26194070 |
| قاعدة البيانات: | MEDLINE |
PDF full text from Publisher | تدمد: | 1744-5116 |
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| DOI: | 10.3109/13880209.2015.1067232 |