دورية أكاديمية
أعرض في EDS

No association of FAM47E rs6812193, SCARB2 rs6825004 and STX1B rs4889603 polymorphisms with Parkinson's disease in a Chinese Han population.

التفاصيل البيبلوغرافية
العنوان: No association of FAM47E rs6812193, SCARB2 rs6825004 and STX1B rs4889603 polymorphisms with Parkinson's disease in a Chinese Han population.
المؤلفون: Chen Y; Department of Neurology, West China Hospital, Sichuan University, 610041, Chengdu, Sichuan, People's Republic of China., Yuan X; Department of Neurology, West China Hospital, Sichuan University, 610041, Chengdu, Sichuan, People's Republic of China., Cao B; Department of Neurology, West China Hospital, Sichuan University, 610041, Chengdu, Sichuan, People's Republic of China., Wei Q; Department of Neurology, West China Hospital, Sichuan University, 610041, Chengdu, Sichuan, People's Republic of China., Ou R; Department of Neurology, West China Hospital, Sichuan University, 610041, Chengdu, Sichuan, People's Republic of China., Yang J; Department of Neurology, West China Hospital, Sichuan University, 610041, Chengdu, Sichuan, People's Republic of China., Chen X; Department of Neurology, West China Hospital, Sichuan University, 610041, Chengdu, Sichuan, People's Republic of China., Zhao B; Department of Neurology, West China Hospital, Sichuan University, 610041, Chengdu, Sichuan, People's Republic of China., Song W; Department of Neurology, West China Hospital, Sichuan University, 610041, Chengdu, Sichuan, People's Republic of China., Wu Y; Department of Neurology, West China Hospital, Sichuan University, 610041, Chengdu, Sichuan, People's Republic of China., Shang H; Department of Neurology, West China Hospital, Sichuan University, 610041, Chengdu, Sichuan, People's Republic of China. hfshang2002@126.com.
المصدر: Journal of neural transmission (Vienna, Austria : 1996) [J Neural Transm (Vienna)] 2015 Nov; Vol. 122 (11), pp. 1547-52. Date of Electronic Publication: 2015 Jul 30.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Springer-Verlag Country of Publication: Austria NLM ID: 9702341 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1435-1463 (Electronic) Linking ISSN: 03009564 NLM ISO Abbreviation: J Neural Transm (Vienna) Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Wien ; New York : Springer-Verlag, 1996-
مواضيع طبية MeSH: Genetic Predisposition to Disease* , Polymorphism, Single Nucleotide*, Lysosomal Membrane Proteins/*genetics , Parkinson Disease/*genetics , Receptors, Scavenger/*genetics , Syntaxin 1/*genetics, Age Factors ; Asian People/genetics ; Case-Control Studies ; China/epidemiology ; Cohort Studies ; Female ; Genetic Association Studies ; Humans ; Male ; Middle Aged ; Models, Genetic ; Parkinson Disease/epidemiology ; Sex Factors
مستخلص: Recently, a series of studies found that the single-nucleotide polymorphisms (SNPs) rs6812193 in the family with sequence similarity 47, member E (FAM47E), rs6825004 in the scavenger receptor class B member 2 (SCARB2) and rs4889603 in the Syntaxin1B (STX1B) genes increase the risk for Parkinson's disease (PD). However, the results of subsequent independent studies were inconsistent. To explore the associations between the three SNPs and PD in the Chinese population, a large cohort was analyzed in a case-control study. A total of 1994 subjects, including 1179 PD and 815 healthy controls (HCs), were investigated. All subjects were genotyped for rs6812193, rs6825004 and rs4889603 using the Sequenom iPLEX Assay. There was no significant difference in additive genetic model of rs6812193, rs6825004 and rs4889603 between PD and controls, even after being stratified by sex and age. In addition, no significant differences were found between other subgroups of PD patients with regard to clinical presentation. Our findings suggested that FAM47E rs6812193, SCARB2 rs6825004 and STX1B rs4889603 do not confer a significant risk for PD in Chinese population.
References: J Neurol Neurosurg Psychiatry. 1992 Mar;55(3):181-4. (PMID: 1564476)
Neurosci Lett. 2013 Apr 29;541:190-2. (PMID: 23473716)
Mov Disord. 2012 Mar;27(3):400-5. (PMID: 22223122)
Neurosci Lett. 2012 May 10;516(1):21-3. (PMID: 22465138)
Mol Genet Metab. 2013 Apr;108(4):269-71. (PMID: 23419877)
Nat Genet. 2014 Sep;46(9):989-93. (PMID: 25064009)
Neurobiol Aging. 2013 Jun;34(6):1708.e7-13. (PMID: 23153929)
Ann N Y Acad Sci. 2003 Jun;991:1-14. (PMID: 12846969)
Neurology. 2000 Dec 12;55(11):1621-6. (PMID: 11113214)
Mov Disord. 2009 Jan 30;24(2):196-203. (PMID: 18973254)
Parkinsonism Relat Disord. 2015 Mar;21(3):300-2. (PMID: 25534083)
Mov Disord. 2013 Apr;28(4):538-40. (PMID: 23408458)
J Am Geriatr Soc. 2005 Apr;53(4):695-9. (PMID: 15817019)
J Mol Neurosci. 2015 Jul;56(3):617-22. (PMID: 25929833)
Science. 1993 Oct 15;262(5132):430-3. (PMID: 8105537)
Cell. 2011 Jul 8;146(1):37-52. (PMID: 21700325)
Neurosci Lett. 2015 Feb 5;587:68-71. (PMID: 25528405)
Nat Genet. 2014 Dec;46(12):1327-32. (PMID: 25362483)
Am J Hum Genet. 2000 Jun;66(6):1821-32. (PMID: 10777718)
Neurosci Lett. 2012 May 23;517(1):56-9. (PMID: 22531747)
PLoS Genet. 2011 Jun;7(6):e1002142. (PMID: 21738488)
PLoS Genet. 2011 Jun;7(6):e1002141. (PMID: 21738487)
Mol Genet Metab. 2014 Feb;111(2):84-91. (PMID: 24389070)
PLoS Genet. 2012;8(3):e1002548. (PMID: 22438815)
Nat Protoc. 2011 Feb;6(2):121-33. (PMID: 21293453)
N Engl J Med. 2009 Oct 22;361(17):1651-61. (PMID: 19846850)
J Neurochem. 2014 Aug;130(4):514-25. (PMID: 24666284)
Control Clin Trials. 1990 Apr;11(2):116-28. (PMID: 2161310)
Neurol Sci. 2015 Aug;36(8):1479-81. (PMID: 25820215)
فهرسة مساهمة: Keywords: Associations; FAM47E; Parkinson’s disease; Polymorphisms; SCARB2; STX1B
المشرفين على المادة: 0 (Lysosomal Membrane Proteins)
0 (Receptors, Scavenger)
0 (SCARB2 protein, human)
0 (STX1B protein, human)
0 (Syntaxin 1)
تواريخ الأحداث: Date Created: 20150731 Date Completed: 20160830 Latest Revision: 20231213
رمز التحديث: 20240628
DOI: 10.1007/s00702-015-1430-4
PMID: 26224037
قاعدة البيانات: MEDLINE
الوصف
تدمد:1435-1463
DOI:10.1007/s00702-015-1430-4