دورية أكاديمية
Decision Making and the IACUC: Part 1- Protocol Information Discussed at Full-Committee Reviews.
| العنوان: | Decision Making and the IACUC: Part 1- Protocol Information Discussed at Full-Committee Reviews. |
|---|---|
| المؤلفون: | Silverman J; Department of Animal Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA; Department of Pathology, University of Massachusetts Medical School, Worcester, Massachusetts, USA. Jerald.silverman@umassmed.edu., Lidz CW; Department of Psychiatry, University of Massachusetts Medical School, Worcester, Massachusetts, USA., Clayfield JC; Department of Psychiatry, University of Massachusetts Medical School, Worcester, Massachusetts, USA., Murray A; Department of Psychiatry, University of Massachusetts Medical School, Worcester, Massachusetts, USA., Simon LJ; Department of Psychiatry, University of Massachusetts Medical School, Worcester, Massachusetts, USA., Rondeau RG; Department of Psychiatry, University of Massachusetts Medical School, Worcester, Massachusetts, USA. |
| المصدر: | Journal of the American Association for Laboratory Animal Science : JAALAS [J Am Assoc Lab Anim Sci] 2015 Jul; Vol. 54 (4), pp. 389-98. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Association for Laboratory Animal Science Country of Publication: United States NLM ID: 101269489 Publication Model: Print Cited Medium: Internet ISSN: 2769-6677 (Electronic) Linking ISSN: 15596109 NLM ISO Abbreviation: J Am Assoc Lab Anim Sci Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Memphis, TN : American Association for Laboratory Animal Science, [2006]- |
| مواضيع طبية MeSH: | Animal Care Committees*, Animal Experimentation/*standards , Animal Welfare/*standards, Analgesia/veterinary ; Animal Welfare/legislation & jurisprudence ; Animals ; Decision Making ; Research Design |
| مستخلص: | IACUC protocols can be reviewed by either the full committee or designated members. Both review methods use the principles of the 3 Rs (reduce, refine, replace) as the overarching paradigm, with federal regulations and policies providing more detailed guidance. The primary goal of this study was to determine the frequency of topics discussed by IACUC during full-committee reviews and whether the topics included those required for consideration by IACUC (for example, pain and distress, number of animals used, availability of alternatives, skill and experience of researchers). We recorded and transcribed 87 protocol discussions undergoing full-committee review at 10 academic institutions. Each transcript was coded to capture the key concepts of the discussion and analyzed for the frequency of the codes mentioned. Pain and distress was the code mentioned most often, followed by the specific procedures performed, the study design, and the completeness of the protocol form. Infrequently mentioned topics were alternatives to animal use or painful or distressful procedures, the importance of the research, and preliminary data. Not all of the topics required to be considered by the IACUC were openly discussed for all protocols, and many of the discussions were limited in their depth. |
| References: | Acad Med. 2012 Jul;87(7):969-74. (PMID: 22622205) Lab Anim. 2014 Jan;48(1):61-71. (PMID: 24367033) J Am Vet Med Assoc. 1989 May 1;194(9):1184-91. (PMID: 2722657) Soc Stud Sci. 2012 Oct;42(5):662-83. (PMID: 23189609) PLoS One. 2011;6(8):e22478. (PMID: 21857928) Med Health Care Philos. 1998;1(1):57-60. (PMID: 11081283) Lab Anim (NY). 2014 Nov;43(11):411-4. (PMID: 25333594) Arthritis Rheum. 2003 Feb;48(2):560-8. (PMID: 12571867) J Empir Res Hum Res Ethics. 2012 Feb;7(1):1-6. (PMID: 22378129) J Med Ethics. 2013 Mar;39(3):188-90. (PMID: 23131895) J Med Philos. 1993 Aug;18(4):375-88. (PMID: 8228684) Ethics Behav. 2003;13(4):333-50. (PMID: 15000096) Lab Anim. 2003 Jan;37(1):10-8. (PMID: 12626068) Ethics Behav. 1992;2(4):263-86. (PMID: 11651614) J Bone Joint Surg Am. 2012 Sep 5;94(17):e132. (PMID: 22992861) Lab Anim. 2002 Oct;36(4):378-95. (PMID: 12396281) Altern Lab Anim. 2005 Oct;33(5):487-500. (PMID: 16268760) Altern Lab Anim. 2009 Jul;37(3):291-6. (PMID: 19678730) J Vet Med Educ. 2011 Summer;38(2):163-70. (PMID: 22023925) Lab Anim. 1999 Jul;33(3):295-303. (PMID: 10780850) Arthritis Rheum. 2007 Feb;56(2):568-74. (PMID: 17265491) Animals (Basel). 2012 Feb 22;2(1):68-75. (PMID: 26486777) Invest Radiol. 1988 Sep;23(9):695-7. (PMID: 3182217) Lab Anim (NY). 2012 Aug;41(8):230-5. (PMID: 22821046) Lab Anim (NY). 2008 Oct;37(10):465-7. (PMID: 18810265) IRB. 2012 Jul-Aug;34(4):15-20. (PMID: 22893993) J Med Ethics. 2009 Apr;35(4):258-61. (PMID: 19332584) Nature. 1992 Mar 12;356(6365):101-2. (PMID: 1545854) J Appl Anim Welf Sci. 2002;5(1):75-81. (PMID: 12738591) J Med Ethics. 2007 May;33(5):294-301. (PMID: 17470508) |
| معلومات مُعتمدة: | R21 RR031900 United States RR NCRR NIH HHS; 5R21RR031900-02 United States RR NCRR NIH HHS |
| تواريخ الأحداث: | Date Created: 20150731 Date Completed: 20151217 Latest Revision: 20181202 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC4521573 |
| PMID: | 26224439 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2769-6677 |
|---|