دورية أكاديمية
Results of a Prospective Multicenter International Atomic Energy Agency Sentinel Node Trial on the Value of SPECT/CT Over Planar Imaging in Various Malignancies.
| العنوان: | Results of a Prospective Multicenter International Atomic Energy Agency Sentinel Node Trial on the Value of SPECT/CT Over Planar Imaging in Various Malignancies. |
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| المؤلفون: | Jimenez-Heffernan A; Hospital Juan Ramon Jimenez, Huelva, Spain., Ellmann A; Stellenbosch University, Tygerberg Hospital, Stellenbosch, South Africa., Sado H; Instituto Do Cancer de Sao Paulo, Sao Paulo, Brazil., Huić D; University Hospital Centre Zagreb, Zagreb, Croatia., Bal C; All India Institute of Medical Sciences, New Delhi, India., Parameswaran R; Manipal Hospital, Bangalore, India., Giammarile F; Hospices Civils, University of Lyon 1, Lyon, France., Pruzzo R; Fundacion Arturo Lopez Perez, Santiago, Chile., Kostadinova I; University Hospital Alexandrovska, Sofia, Bulgaria., Vorster M; Pretoria Academic Hospital, Pretoria, South Africa., Almeida P; Real Hospital Português, Recife, Brazil., Santiago J; St. Lukes Medical Center, Quezon City, Philippines., Gambhir S; Sanjay Gandhi Institute of Medical Sciences, Lucknow, India., Sergieva S; Sofia Cancer Center, Sofia, Bulgaria., Calderon A; Instituto Nacional de Cancerlologia, Bogota, Colombia., Young GO; Universidade de Sao Paulo, Sao Paulo, Brazil., Valdes-Olmos R; The Netherlands Cancer Institute, Amsterdam, The Netherlands., Zaknun J; IAEA, Vienna, Austria; and., Magboo VP; University of the Philippines Manila, Manila, Philippines., Pascual TN; IAEA, Vienna, Austria; and T.Pascual@iaea.org. |
| المصدر: | Journal of nuclear medicine : official publication, Society of Nuclear Medicine [J Nucl Med] 2015 Sep; Vol. 56 (9), pp. 1338-44. Date of Electronic Publication: 2015 Jul 30. |
| نوع المنشور: | Comparative Study; Controlled Clinical Trial; Journal Article; Multicenter Study |
| اللغة: | English |
| بيانات الدورية: | Publisher: Society of Nuclear Medicine Country of Publication: United States NLM ID: 0217410 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1535-5667 (Electronic) Linking ISSN: 01615505 NLM ISO Abbreviation: J Nucl Med Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Reston, VA : Society of Nuclear Medicine Original Publication: [Chicago, Ill.] : S.N. Turiel & Assoc. |
| مواضيع طبية MeSH: | Lymph Nodes/*diagnostic imaging , Multimodal Imaging/*methods , Neoplasms/*diagnosis , Tomography, Emission-Computed, Single-Photon/*methods , Tomography, X-Ray Computed/*methods, Female ; Humans ; International Agencies ; Lymphatic Metastasis ; Male ; Middle Aged ; Radionuclide Imaging/methods ; Reproducibility of Results ; Sensitivity and Specificity ; Sentinel Lymph Node Biopsy |
| مستخلص: | Unlabelled: We aimed to assess the additional value of SPECT/CT over planar lymphoscintigraphy (PI) in sentinel node (SN) detection in malignancies with different lymphatic drainage such as breast cancer, melanoma, and pelvic tumors. Methods: From 2010 to 2013, 1,508 patients were recruited in a multicenter study: 1,182 breast cancer, 262 melanoma, and 64 pelvic malignancies (prostate, cervix, penis, vulva). PI was followed by SPECT/CT 1-3 h after injection of (99m)Tc-colloid particles. Surgery was performed the same or next day. Results: Significantly more SNs were detected by SPECT/CT for breast cancer (2,165 vs. 1,892), melanoma (602 vs. 532), and pelvic cancer (195 vs. 138), all P < 0.001. The drainage basin mismatch between PI and SPECT/CT was 16.5% for breast cancer, 11.1% for melanoma, and 51.6% for pelvic cancers. Surgical adjustment was 17% for breast cancer, 37% for melanoma, and 65.6% for pelvic cancer. Conclusion: SPECT/CT detected more SNs and changed the drainage territory, leading to surgical adjustments in a considerable number of patients in all malignancies studied but especially in the pelvic cancer group because of this group's deep lymphatic drainage. We recommend SPECT/CT in all breast cancer patients with no SN visualized on PI, all patients with melanoma of the head and neck or trunk, all patients with pelvic malignancies, and those breast cancer and melanoma patients with unexpected drainage on PI. (© 2015 by the Society of Nuclear Medicine and Molecular Imaging, Inc.) |
| فهرسة مساهمة: | Keywords: SPECT/CT; breast cancer; melanoma; pelvic cancer; sentinel node |
| تواريخ الأحداث: | Date Created: 20150801 Date Completed: 20151124 Latest Revision: 20220318 |
| رمز التحديث: | 20231215 |
| DOI: | 10.2967/jnumed.114.153643 |
| PMID: | 26229148 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1535-5667 |
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| DOI: | 10.2967/jnumed.114.153643 |