دورية أكاديمية
أعرض في EDS

Pathogenicity of Bovine Neonatal Pancytopenia-associated vaccine-induced alloantibodies correlates with Major Histocompatibility Complex class I expression.

التفاصيل البيبلوغرافية
العنوان: Pathogenicity of Bovine Neonatal Pancytopenia-associated vaccine-induced alloantibodies correlates with Major Histocompatibility Complex class I expression.
المؤلفون: Benedictus L; Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands., Luteijn RD; Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, The Netherlands., Otten H; Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, The Netherlands., Lebbink RJ; Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, The Netherlands., van Kooten PJ; Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands., Wiertz EJ; Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, The Netherlands., Rutten VP; 1] Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands [2] Department of Veterinary Tropical Diseases, Faculty of Veterinary Science, University of Pretoria, Onderstepoort, South Africa., Koets AP; 1] Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands [2] Department of Farm Animal Health, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.
المصدر: Scientific reports [Sci Rep] 2015 Aug 03; Vol. 5, pp. 12748. Date of Electronic Publication: 2015 Aug 03.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : Nature Publishing Group, copyright 2011-
مواضيع طبية MeSH: Cattle Diseases/*immunology , Histocompatibility Antigens Class I/*immunology , Isoantibodies/*immunology , Pancytopenia/*veterinary , Viral Vaccines/*adverse effects, Animals ; Antibody Specificity ; Cattle ; Cell Line ; Female ; Histocompatibility Antigens Class I/metabolism ; Humans ; Integrin beta1/immunology ; Integrin beta1/metabolism ; Pancytopenia/immunology ; Pregnancy
مستخلص: Bovine Neonatal Pancytopenia (BNP), a fatal bleeding syndrome of neonatal calves, is caused by maternal alloantibodies absorbed from colostrum and is characterized by lymphocytopenia, thrombocytopenia and bone marrow hypoplasia. An inactivated viral vaccine is the likely source of alloantigens inducing BNP-associated alloantibodies in the dam. In this study the specificity of BNP alloantibodies was assessed and was linked to the pathology of BNP. We demonstrated that Major Histocompatibility Complex class I (MHC I) and Very Late Antigen-3, an integrin α3/β1 heterodimer, were the major targets of BNP alloantibodies. However, alloantibody binding to various bovine cell types correlated with MHC I expression, rather than integrin β1 or α3 expression. Likewise, alloantibody-dependent complement-mediated cell lysis correlated strongly with MHC I expression. Examination of several tissues of third trimester bovine foetuses revealed that cells, shown to be affected in calves with BNP, were characterized by high MHC class I expression and high levels of alloantibody binding. We conclude that in spite of the heterogeneous specificity of BNP associated maternal alloantibodies, MHC I-specific antibodies mediate the pathogenicity of BNP in the calf and that cells with high MHC I expression were preferentially affected in BNP.
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المشرفين على المادة: 0 (Histocompatibility Antigens Class I)
0 (Integrin beta1)
0 (Isoantibodies)
0 (Viral Vaccines)
تواريخ الأحداث: Date Created: 20150804 Date Completed: 20170829 Latest Revision: 20181113
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC4522679
DOI: 10.1038/srep12748
PMID: 26235972
قاعدة البيانات: MEDLINE
الوصف
تدمد:2045-2322
DOI:10.1038/srep12748