دورية أكاديمية
أعرض في EDS

Assessment of glenoid chondral healing: comparison of microfracture to autologous matrix-induced chondrogenesis in a novel rabbit shoulder model.

التفاصيل البيبلوغرافية
العنوان: Assessment of glenoid chondral healing: comparison of microfracture to autologous matrix-induced chondrogenesis in a novel rabbit shoulder model.
المؤلفون: Wang VM; Department of Orthopedic Surgery, Rush University Medical Center, Chicago, IL, USA., Karas V; Department of Orthopedic Surgery, Rush University Medical Center, Chicago, IL, USA., Lee AS; Department of Orthopedic Surgery, Rush University Medical Center, Chicago, IL, USA., Yin Z; Department of Bioengineering, University of Illinois at Chicago, Chicago, IL, USA., Van Thiel GS; Rockford Orthopedic Associates, Rockford, IL, USA., Hussey K; Department of Orthopedic Surgery, Rush University Medical Center, Chicago, IL, USA., Sumner DR; Department of Anatomy and Cell Biology, Rush University Medical Center, Chicago, IL, USA., Chubinskaya S; Department of Biochemistry, Rush University Medical Center, Chicago, IL, USA., Magin RL; Department of Bioengineering, University of Illinois at Chicago, Chicago, IL, USA., Verma NN; Department of Orthopedic Surgery, Rush University Medical Center, Chicago, IL, USA., Romeo AA; Department of Orthopedic Surgery, Rush University Medical Center, Chicago, IL, USA., Cole BJ; Department of Orthopedic Surgery, Rush University Medical Center, Chicago, IL, USA. Electronic address: bcole@rushortho.com.
المصدر: Journal of shoulder and elbow surgery [J Shoulder Elbow Surg] 2015 Nov; Vol. 24 (11), pp. 1789-800. Date of Electronic Publication: 2015 Aug 01.
نوع المنشور: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Mosby Country of Publication: United States NLM ID: 9206499 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-6500 (Electronic) Linking ISSN: 10582746 NLM ISO Abbreviation: J Shoulder Elbow Surg Subsets: MEDLINE
أسماء مطبوعة: Publication: St. Louis, MO : Mosby
Original Publication: St. Louis, MO : Mosby Yearbook, Inc., c1992-
مواضيع طبية MeSH: Arthroplasty, Subchondral* , Chondrogenesis* , Wound Healing*, Cartilage, Articular/*surgery , Shoulder/*surgery, Animals ; Cartilage, Articular/diagnostic imaging ; Cartilage, Articular/pathology ; Collagen Type I/administration & dosage ; Collagen Type III/administration & dosage ; Imaging, Three-Dimensional ; Models, Animal ; Rabbits ; Tissue Scaffolds ; X-Ray Microtomography
مستخلص: Background: Management of glenohumeral arthrosis in young patients is a considerable challenge, with a growing need for non-arthroplasty alternatives. The objectives of this study were to develop an animal model to study glenoid cartilage repair and to compare surgical repair strategies to promote glenoid chondral healing.
Methods: Forty-five rabbits underwent unilateral removal of the entire glenoid articular surface and were divided into 3 groups--untreated defect (UD), microfracture (MFx), and MFx plus type I/III collagen scaffold (autologous matrix-induced chondrogenesis [AMIC])--for the evaluation of healing at 8 weeks (12 rabbits) and 32 weeks (33 rabbits) after injury. Contralateral shoulders served as unoperated controls. Tissue assessments included 11.7-T magnetic resonance imaging (long-term healing group only), equilibrium partitioning of an ionic contrast agent via micro-computed tomography (EPIC-μCT), and histologic investigation (grades on International Cartilage Repair Society II scoring system).
Results: At 8 weeks, x-ray attenuation, thickness, and volume did not differ by treatment group. At 32 weeks, the T2 index (ratio of T2 values of healing to intact glenoids) was significantly lower for the MFx group relative to the AMIC group (P = .01) whereas the T1ρ index was significantly lower for AMIC relative to MFx (P = .01). The micro-computed tomography-derived repair tissue volume was significantly higher for MFx than for UD. Histologic investigation generally suggested inferior healing in the AMIC and UD groups relative to the MFx group, which exhibited improvements in both integration of repair tissue with subchondral bone and tidemark formation over time.
Discussion: Improvements conferred by AMIC were limited to magnetic resonance imaging outcomes, whereas MFx appeared to promote increased fibrous tissue deposition via micro-computed tomography and more hyaline-like repair histologically. The findings from this novel model suggest that MFx promotes biologic resurfacing of full-thickness glenoid articular injury.
(Copyright © 2015 Journal of Shoulder and Elbow Surgery Board of Trustees. Published by Elsevier Inc. All rights reserved.)
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معلومات مُعتمدة: R01 EB007537 United States EB NIBIB NIH HHS; T32 AR052272 United States AR NIAMS NIH HHS; AR052272 United States AR NIAMS NIH HHS; EB007537 United States EB NIBIB NIH HHS
فهرسة مساهمة: Keywords: Glenohumeral; animal model; articular cartilage; autologous matrix-induced chondrogenesis; microfracture
المشرفين على المادة: 0 (Collagen Type I)
0 (Collagen Type III)
تواريخ الأحداث: Date Created: 20150805 Date Completed: 20160602 Latest Revision: 20181202
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC4618188
DOI: 10.1016/j.jse.2015.06.008
PMID: 26238005
قاعدة البيانات: MEDLINE
الوصف
تدمد:1532-6500
DOI:10.1016/j.jse.2015.06.008