دورية أكاديمية
أعرض في EDS

Early Developmental and Evolutionary Origins of Gene Body DNA Methylation Patterns in Mammalian Placentas.

التفاصيل البيبلوغرافية
العنوان: Early Developmental and Evolutionary Origins of Gene Body DNA Methylation Patterns in Mammalian Placentas.
المؤلفون: Schroeder DI; Department of Medical Microbiology and Immunology, The University of California Davis School of Medicine, Davis, California, United States of America; University of California Davis Genome Center, University of California Davis, Davis, California, United States of America; University of California Davis MIND Institute, University of California Davis, Sacramento, California, United States of America., Jayashankar K; Department of Population Health and Reproduction, UC Davis School of Veterinary Medicine, Davis, California, United States of America., Douglas KC; Department of Veterinary Integrative Biosciences, Texas A&M University, College Station, Texas, United States of America., Thirkill TL; Department of Cell Biology and Human Anatomy, University of California Davis School of Medicine, Davis, California, United States of America., York D; Department of Surgical and Radiological Sciences, University of California School of Veterinary Medicine, Davis, California, United States of America., Dickinson PJ; Department of Surgical and Radiological Sciences, University of California School of Veterinary Medicine, Davis, California, United States of America., Williams LE; Department of Veterinary Sciences, University of Texas MD Anderson Cancer Center, Bastrop, Texas, United States of America., Samollow PB; Department of Veterinary Integrative Biosciences, Texas A&M University, College Station, Texas, United States of America., Ross PJ; Department of Animal Science, University of California Davis, Davis, California, United States of America., Bannasch DL; Department of Population Health and Reproduction, UC Davis School of Veterinary Medicine, Davis, California, United States of America., Douglas GC; Department of Cell Biology and Human Anatomy, University of California Davis School of Medicine, Davis, California, United States of America., LaSalle JM; Department of Medical Microbiology and Immunology, The University of California Davis School of Medicine, Davis, California, United States of America; University of California Davis Genome Center, University of California Davis, Davis, California, United States of America; University of California Davis MIND Institute, University of California Davis, Sacramento, California, United States of America.
المصدر: PLoS genetics [PLoS Genet] 2015 Aug 04; Vol. 11 (8), pp. e1005442. Date of Electronic Publication: 2015 Aug 04 (Print Publication: 2015).
نوع المنشور: Comparative Study; Journal Article; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101239074 Publication Model: eCollection Cited Medium: Internet ISSN: 1553-7404 (Electronic) Linking ISSN: 15537390 NLM ISO Abbreviation: PLoS Genet Subsets: MEDLINE
أسماء مطبوعة: Original Publication: San Francisco, CA : Public Library of Science, c2005-
مواضيع طبية MeSH: DNA Methylation*, Placenta/*physiology, Animals ; Cattle ; Cells, Cultured ; Dogs ; Epigenesis, Genetic ; Evolution, Molecular ; Female ; Horses ; Macaca mulatta ; Mice ; Oocytes/physiology ; Open Reading Frames ; Opossums ; Pregnancy ; Saimiri ; Species Specificity ; Transcription, Genetic
مستخلص: Over the last 20-80 million years the mammalian placenta has taken on a variety of morphologies through both divergent and convergent evolution. Recently we have shown that the human placenta genome has a unique epigenetic pattern of large partially methylated domains (PMDs) and highly methylated domains (HMDs) with gene body DNA methylation positively correlating with level of gene expression. In order to determine the evolutionary conservation of DNA methylation patterns and transcriptional regulatory programs in the placenta, we performed a genome-wide methylome (MethylC-seq) analysis of human, rhesus macaque, squirrel monkey, mouse, dog, horse, and cow placentas as well as opossum extraembryonic membrane. We found that, similar to human placenta, mammalian placentas and opossum extraembryonic membrane have globally lower levels of methylation compared to somatic tissues. Higher relative gene body methylation was the conserved feature across all mammalian placentas, despite differences in PMD/HMDs and absolute methylation levels. Specifically, higher methylation over the bodies of genes involved in mitosis, vesicle-mediated transport, protein phosphorylation, and chromatin modification was observed compared with the rest of the genome. As in human placenta, higher methylation is associated with higher gene expression and is predictive of genic location across species. Analysis of DNA methylation in oocytes and preimplantation embryos shows a conserved pattern of gene body methylation similar to the placenta. Intriguingly, mouse and cow oocytes and mouse early embryos have PMD/HMDs but their placentas do not, suggesting that PMD/HMDs are a feature of early preimplantation methylation patterns that become lost during placental development in some species and following implantation of the embryo.
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معلومات مُعتمدة: R01ES021707 United States ES NIEHS NIH HHS; P01 ES011269 United States ES NIEHS NIH HHS; P40 OD010938 United States OD NIH HHS; R01 HD070044 United States HD NICHD NIH HHS; S10RR029668 United States RR NCRR NIH HHS; R01NS081913 United States NS NINDS NIH HHS; S10RR027303 United States RR NCRR NIH HHS; S10 RR029668 United States RR NCRR NIH HHS; S10 RR027303 United States RR NCRR NIH HHS; R24 RR014214 United States RR NCRR NIH HHS; R01 ES021707 United States ES NIEHS NIH HHS; 8P40OD010938 United States OD NIH HHS; R01 NS081913 United States NS NINDS NIH HHS
تواريخ الأحداث: Date Created: 20150805 Date Completed: 20160510 Latest Revision: 20201215
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC4524645
DOI: 10.1371/journal.pgen.1005442
PMID: 26241857
قاعدة البيانات: MEDLINE
الوصف
تدمد:1553-7404
DOI:10.1371/journal.pgen.1005442