دورية أكاديمية
Antiseptic effect of vicenin-2 and scolymoside from Cyclopia subternata (honeybush) in response to HMGB1 as a late sepsis mediator in vitro and in vivo.
| العنوان: | Antiseptic effect of vicenin-2 and scolymoside from Cyclopia subternata (honeybush) in response to HMGB1 as a late sepsis mediator in vitro and in vivo. |
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| المؤلفون: | Lee W; a College of Pharmacy, CMRI, Research Institute of Pharmaceutical Sciences, Kyungpook National University, 80 Dahak-ro, Buk-gu, Daegu 702-701, Republic of Korea.; b Department of Biochemistry and Cell Biology, BK21 Plus KNU Biomedical Convergence Program, School of Medicine, Kyungpook National University, Daegu 702-701, Republic of Korea., Yoon EK; a College of Pharmacy, CMRI, Research Institute of Pharmaceutical Sciences, Kyungpook National University, 80 Dahak-ro, Buk-gu, Daegu 702-701, Republic of Korea., Kim KM; c Division of Plant Biosciences, School of Applied BioSciences, College of Agriculture and Life Science, Kyungpook National University, Daegu 702-701, Republic of Korea., Park DH; d Department of Ophthalmology, School of Medicine, Kyungpook National University, 50 Samduk-dong-2-ga, Jung-gu, Daegu 700-721, Republic of Korea., Bae JS; a College of Pharmacy, CMRI, Research Institute of Pharmaceutical Sciences, Kyungpook National University, 80 Dahak-ro, Buk-gu, Daegu 702-701, Republic of Korea. |
| المصدر: | Canadian journal of physiology and pharmacology [Can J Physiol Pharmacol] 2015 Aug; Vol. 93 (8), pp. 709-20. Date of Electronic Publication: 2015 Apr 22. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Canadian Science Publishing Country of Publication: Canada NLM ID: 0372712 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1205-7541 (Electronic) Linking ISSN: 00084212 NLM ISO Abbreviation: Can J Physiol Pharmacol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2011- : Ottawa, ON : Canadian Science Publishing Original Publication: Ottawa, National Research Council of Canada. |
| مواضيع طبية MeSH: | Cyclopia Plant*/chemistry, Anti-Infective Agents, Local/*pharmacology , Anti-Inflammatory Agents/*pharmacology , Apigenin/*pharmacology , Glucosides/*pharmacology , HMGB1 Protein/*pharmacology , Human Umbilical Vein Endothelial Cells/*drug effects , Luteolin/*pharmacology , Sepsis/*drug therapy, Animals ; Apigenin/isolation & purification ; Cell Adhesion/drug effects ; Cell Membrane Permeability/drug effects ; Cell Movement/drug effects ; Cells, Cultured ; Coculture Techniques ; Glucosides/isolation & purification ; HMGB1 Protein/antagonists & inhibitors ; Human Umbilical Vein Endothelial Cells/metabolism ; Humans ; Inflammation Mediators/metabolism ; Lipopolysaccharides/pharmacology ; Luteolin/isolation & purification ; Male ; Mice, Inbred C57BL ; Neutrophils/drug effects ; Neutrophils/metabolism ; Phytotherapy ; Plants, Medicinal ; Sepsis/metabolism ; Sepsis/microbiology ; Signal Transduction/drug effects |
| مستخلص: | Cyclopia subternata is a medicinal plant commonly used in traditional medicine to relieve pain. In this study, we investigated the antiseptic effects and underlying mechanisms of vicenin-2 and scolymoside, which are 2 active compounds from C. subternata that act against high mobility group box 1 (HMGB1)-mediated septic responses in human umbilical vein endothelial cells (HUVECs) and mice. The antiseptic activities of vicenin-2 and scolymoside were determined by measuring permeability, neutrophil adhesion and migration, and activation of proinflammatory proteins in HMGB1-activated HUVECs and mice. According to the results, vicenin-2 and scolymoside effectively inhibited lipopolysaccharide-induced release of HMGB1, and suppressed HMGB1-mediated septic responses such as hyperpermeability, the adhesion and migration of leukocytes, and the expression of cell adhesion molecules. In addition, vicenin-2 and scolymoside suppressed the production of tumor necrosis factor-α and interleukin 6, and activation of nuclear factor-κB and extracellular regulated kinases 1/2 by HMGB1. Collectively, these results indicate that vicenin-2 and scolymoside could be a potential therapeutic agents for the treatment of various severe vascular inflammatory diseases via inhibition of the HMGB1 signaling pathway. |
| فهرسة مساهمة: | Keywords: HMGB1; inflammation; scolymoside; sepsie; sepsis; vicenin-2; vicenine-2 |
| المشرفين على المادة: | 0 (Anti-Infective Agents, Local) 0 (Anti-Inflammatory Agents) 0 (Glucosides) 0 (HMGB1 Protein) 0 (HMGB1 protein, human) 0 (Inflammation Mediators) 0 (Lipopolysaccharides) 0 (apigenin-6,8-di-C-glycopyranoside) 0 (lipopolysaccharide, Escherichia coli O111 B4) 0 (scolymoside) 7V515PI7F6 (Apigenin) KUX1ZNC9J2 (Luteolin) |
| تواريخ الأحداث: | Date Created: 20150806 Date Completed: 20160503 Latest Revision: 20160627 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1139/cjpp-2015-0021 |
| PMID: | 26243020 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1205-7541 |
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| DOI: | 10.1139/cjpp-2015-0021 |