دورية أكاديمية
Increasing levels of the endocannabinoid 2-AG is neuroprotective in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease.
العنوان: | Increasing levels of the endocannabinoid 2-AG is neuroprotective in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease. |
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المؤلفون: | Mounsey RB; Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD Scotland, UK., Mustafa S; Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD Scotland, UK., Robinson L; Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD Scotland, UK; Ninewells Hospital and Medical School, University of Dundee, Dundee, DD1 9SY Scotland, UK., Ross RA; Department of Pharmacology and Toxicology, University of Toronto, Medical Sciences Building, 1 King's College Circle, Toronto, Ontario M5S 1A, Canada., Riedel G; Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD Scotland, UK., Pertwee RG; Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD Scotland, UK., Teismann P; Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD Scotland, UK. Electronic address: p.teismann@abdn.ac.uk. |
المصدر: | Experimental neurology [Exp Neurol] 2015 Nov; Vol. 273, pp. 36-44. Date of Electronic Publication: 2015 Aug 02. |
نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: Academic Press Country of Publication: United States NLM ID: 0370712 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2430 (Electronic) Linking ISSN: 00144886 NLM ISO Abbreviation: Exp Neurol Subsets: MEDLINE |
أسماء مطبوعة: | Publication: Orlando Fl : Academic Press Original Publication: New York. |
مواضيع طبية MeSH: | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine*/pharmacology, Arachidonic Acids/*therapeutic use , Endocannabinoids/*therapeutic use , Glycerides/*therapeutic use , Neuroprotective Agents/*therapeutic use , Neurotoxins/*toxicity , Parkinson Disease/*diet therapy , Parkinson Disease/*etiology, Animals ; Benzodioxoles/therapeutic use ; Brain/drug effects ; Brain/metabolism ; Brain/pathology ; Cell Death/drug effects ; Cyclooxygenase 2/metabolism ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Enzyme Inhibitors/pharmacology ; Furans/therapeutic use ; Gait Disorders, Neurologic/drug therapy ; Gait Disorders, Neurologic/etiology ; Male ; Mice ; Mice, Inbred C57BL ; Motor Activity/drug effects ; Parkinson Disease/complications ; Parkinson Disease/pathology ; Piperidines/therapeutic use ; Time Factors ; Tyrosine 3-Monooxygenase/metabolism |
مستخلص: | Parkinson's disease (PD) is a common chronic neurodegenerative disorder, usually of idiopathic origin. Symptoms including tremor, bradykinesia, rigidity and postural instability are caused by the progressive loss of dopaminergic neurons in the nigrostriatal region of the brain. Symptomatic therapies are available but no treatment slows or prevents the loss of neurons. Neuroinflammation has been implicated in its pathogenesis. To this end, the present study utilises the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxin to reproduce the pattern of cell death evident in PD patients. Herein, the role of a potential regulator of an immune response, the endocannabinoid system (ECS), is investigated. The most prevalent endocannabinoid, 2-arachidonoylglycerol (2-AG) (3 and 5mg/kg), was added exogenously and its enzymatic degradation inhibited to provide protection against MPTP-induced cell death. Furthermore, the addition of DFU (25mg/kg), a selective inhibitor of inflammatory mediator cyclooxygenase-2 (COX-2), potentiated these effects. Levels of 2-AG were shown to be upregulated in a time- and region-specific manner following MPTP administration, indicating that the ECS represents a natural defence mechanism against inflammation, potentiation of which could provide therapeutic benefits. The results expand the current understanding of the role that this signalling system has and its potential influence in PD. (Copyright © 2015. Published by Elsevier Inc.) |
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معلومات مُعتمدة: | WT080782MF United Kingdom Wellcome Trust |
فهرسة مساهمة: | Keywords: Endocannabinoids; MPTP; Neuroprotection; Parkinson's disease |
المشرفين على المادة: | 0 (5,5-dimethyl-3-(3-fluorophenyl)-4-(4-methylsulfonyl)phenyl-2(5H)-furanone) 0 (Arachidonic Acids) 0 (Benzodioxoles) 0 (Endocannabinoids) 0 (Enzyme Inhibitors) 0 (Furans) 0 (Glycerides) 0 (JZL 184) 0 (Neuroprotective Agents) 0 (Neurotoxins) 0 (Piperidines) 8D239QDW64 (glyceryl 2-arachidonate) 9P21XSP91P (1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine) EC 1.14.16.2 (Tyrosine 3-Monooxygenase) EC 1.14.99.1 (Cyclooxygenase 2) |
تواريخ الأحداث: | Date Created: 20150806 Date Completed: 20160218 Latest Revision: 20181113 |
رمز التحديث: | 20231215 |
مُعرف محوري في PubMed: | PMC4654430 |
DOI: | 10.1016/j.expneurol.2015.07.024 |
PMID: | 26244281 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1090-2430 |
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DOI: | 10.1016/j.expneurol.2015.07.024 |