دورية أكاديمية
أعرض في EDS

Daytime Sleepiness and Sleep Inadequacy as Risk Factors for Dementia.

التفاصيل البيبلوغرافية
العنوان: Daytime Sleepiness and Sleep Inadequacy as Risk Factors for Dementia.
المؤلفون: Tsapanou A; Cognitive Neuroscience Division, Department of Neurology, New York, N.Y., USA ; The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, New York, N.Y., USA., Gu Y; Cognitive Neuroscience Division, Department of Neurology, New York, N.Y., USA ; The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, New York, N.Y., USA., Manly J; The Gertrude H. Sergievsky Center, Columbia University College of Physicians and Surgeons, New York, N.Y., USA ; Department of Neurology, Columbia University College of Physicians and Surgeons, New York, N.Y., USA., Schupf N; Cognitive Neuroscience Division, Department of Neurology, New York, N.Y., USA ; The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, New York, N.Y., USA ; The Gertrude H. Sergievsky Center, Columbia University College of Physicians and Surgeons, New York, N.Y., USA ; Division of Epidemiology, Joseph P. Mailman School of Public Health, Columbia University, New York, N.Y., USA., Tang MX; The Gertrude H. Sergievsky Center, Columbia University College of Physicians and Surgeons, New York, N.Y., USA ; Department of Biostatistics, Joseph P. Mailman School of Public Health, Columbia University, New York, N.Y., USA., Zimmerman M; Department of Psychology, Fordham University, Bronx, N.Y., USA., Scarmeas N; Cognitive Neuroscience Division, Department of Neurology, New York, N.Y., USA ; The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, New York, N.Y., USA ; The Gertrude H. Sergievsky Center, Columbia University College of Physicians and Surgeons, New York, N.Y., USA ; Department of Neurology, Columbia University College of Physicians and Surgeons, New York, N.Y., USA ; National and Kapodistrian University of Athens Medical School, Athens, Greece., Stern Y; Cognitive Neuroscience Division, Department of Neurology, New York, N.Y., USA ; The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, New York, N.Y., USA ; The Gertrude H. Sergievsky Center, Columbia University College of Physicians and Surgeons, New York, N.Y., USA ; Department of Neurology, Columbia University College of Physicians and Surgeons, New York, N.Y., USA.
المصدر: Dementia and geriatric cognitive disorders extra [Dement Geriatr Cogn Dis Extra] 2015 Jul 10; Vol. 5 (2), pp. 286-95. Date of Electronic Publication: 2015 Jul 10 (Print Publication: 2015).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Karger Country of Publication: Switzerland NLM ID: 101564825 Publication Model: eCollection Cited Medium: Print ISSN: 1664-5464 (Print) Linking ISSN: 16645464 NLM ISO Abbreviation: Dement Geriatr Cogn Dis Extra Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Basel : Karger
مستخلص: Background/aims: To examine the association between self-reported sleep problems and incidence of dementia in community-dwelling elderly people.
Methods: 1,041 nondemented participants over 65 years old were examined longitudinally. Sleep problems were estimated using the RAND Medical Outcomes Study Sleep Scale examining sleep disturbance, snoring, sleep short of breath or with a headache, sleep adequacy, and sleep somnolence. Cox regression analysis was used to examine the association between sleep problems and risk for incident dementia. Age, gender, education, ethnicity, APOE-ε4, stroke, heart disease, hypertension, diabetes, and depression were included as covariates.
Results: Over 3 years of follow-up, 966 (92.8%) participants remained nondemented, while 78 (7.2%) developed dementia. In unadjusted models, sleep inadequacy ('Get the amount of sleep you need') at the initial visit was associated with increased risk of incident dementia (HR = 1.20; 95% CI 1.02-1.42; p = 0.027). Adjusting for all the covariates, increased risk of incident dementia was still associated with sleep inadequacy (HR = 1.20; 95% CI 1.01-1.42; p = 0.040), as well as with increased daytime sleepiness ('Have trouble staying awake during the day') (HR = 1.24; 95% CI 1.00-1.54; p = 0.047).
Conclusion: Our results suggest that sleep inadequacy and increased daytime sleepiness are risk factors for dementia in older adults, independent of demographic and clinical factors.
References: Neurology. 1974 Nov;24(11):1019-25. (PMID: 4473151)
Lancet Neurol. 2014 Oct;13(10):1017-28. (PMID: 25231524)
Am J Geriatr Psychiatry. 2014 Nov;22(11):1262-71. (PMID: 23954041)
Int J Geriatr Psychiatry. 2016 Mar;31(3):247-55. (PMID: 26081795)
Neurotox Res. 2008 Oct;14(2-3):263-72. (PMID: 19073431)
Arch Intern Med. 1999 Aug 9-23;159(15):1701-4. (PMID: 10448771)
J Am Geriatr Soc. 2014 Jun;62(6):1073-81. (PMID: 24786726)
J Alzheimers Dis. 2012;30(1):75-82. (PMID: 22377782)
Eur J Neurol. 2009 Sep;16(9):990-7. (PMID: 19473367)
Arch Neurol. 1992 May;49(5):453-60. (PMID: 1580806)
Brain. 2006 Mar;129(Pt 3):564-83. (PMID: 16399806)
Int J Geriatr Psychiatry. 2010 Jan;25(1):100-9. (PMID: 19548221)
Sleep Med Rev. 2009 Jun;13(3):187-94. (PMID: 18848476)
Neurobiol Dis. 2012 Dec;48(3):348-55. (PMID: 22776332)
Sleep. 2013 Jul 1;36(7):1027-1032. (PMID: 23814339)
JAMA Neurol. 2013 Dec;70(12 ):1537-43. (PMID: 24145859)
BMC Neurol. 2014 Apr 06;14:76. (PMID: 24708629)
Alzheimers Dement. 2011 May;7(3):263-9. (PMID: 21514250)
Trends Cogn Sci. 2011 Nov;15(11):520-6. (PMID: 21983147)
Arch Neurol. 2005 Nov;62(11):1739-46. (PMID: 16286549)
Sleep. 2013 Oct 01;36(10 ):1533-41, 1541A. (PMID: 24082313)
Stroke. 2011 Sep;42(9):2672-713. (PMID: 21778438)
Neurologist. 2012 Nov;18(6):426-9. (PMID: 23114683)
Curr Alzheimer Res. 2014;11(7):681-93. (PMID: 25115541)
J Am Geriatr Soc. 2001 Dec;49(12):1628-32. (PMID: 11843995)
Am J Psychiatry. 2014 May;171(5):572-81. (PMID: 24700290)
J Epidemiol Community Health. 2011 Sep;65(9):820-4. (PMID: 20675705)
J Am Geriatr Soc. 2008 Jul;56(7):1228-35. (PMID: 18482297)
J Clin Exp Neuropsychol. 2011 Feb;33(2):242-8. (PMID: 20865618)
J Hypertens. 2013 Sep;31(9):1868-75. (PMID: 23743809)
Neuropsychiatr Dis Treat. 2005 Jun;1(2):155-63. (PMID: 18568061)
Neurobiol Aging. 2015 Jan;36(1):27-32. (PMID: 25155654)
Arch Neurol. 2012 Jan;69(1):51-8. (PMID: 21911660)
J Affect Disord. 2008 Jan;105(1-3):273-7. (PMID: 17532052)
Sleep. 1995 Jul;18(6):425-32. (PMID: 7481413)
JAMA. 1998 Mar 11;279(10):751-5. (PMID: 9508150)
J Alzheimers Dis. 2015 ;43(4):1441-9. (PMID: 25159674)
Neurology. 2001 Jan 9;56(1):49-56. (PMID: 11148235)
CNS Drugs. 2001;15(10):777-96. (PMID: 11602004)
Neurology. 1984 Jul;34(7):939-44. (PMID: 6610841)
Ann Neurol. 2011 Nov;70(5):722-32. (PMID: 22162057)
معلومات مُعتمدة: Z01 AG007370 United States ImNIH Intramural NIH HHS; K99 AG042483 United States AG NIA NIH HHS; R00 AG042483 United States AG NIA NIH HHS; R01 AG037212 United States AG NIA NIH HHS; R01 AG007370 United States AG NIA NIH HHS
فهرسة مساهمة: Keywords: Daytime sleepiness; Dementia; Elderly; Longitudinal study; Sleep adequacy
تواريخ الأحداث: Date Created: 20150815 Date Completed: 20150814 Latest Revision: 20220331
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC4521063
DOI: 10.1159/000431311
PMID: 26273244
قاعدة البيانات: MEDLINE
الوصف
تدمد:1664-5464
DOI:10.1159/000431311