دورية أكاديمية
Daytime Sleepiness and Sleep Inadequacy as Risk Factors for Dementia.
العنوان: | Daytime Sleepiness and Sleep Inadequacy as Risk Factors for Dementia. |
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المؤلفون: | Tsapanou A; Cognitive Neuroscience Division, Department of Neurology, New York, N.Y., USA ; The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, New York, N.Y., USA., Gu Y; Cognitive Neuroscience Division, Department of Neurology, New York, N.Y., USA ; The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, New York, N.Y., USA., Manly J; The Gertrude H. Sergievsky Center, Columbia University College of Physicians and Surgeons, New York, N.Y., USA ; Department of Neurology, Columbia University College of Physicians and Surgeons, New York, N.Y., USA., Schupf N; Cognitive Neuroscience Division, Department of Neurology, New York, N.Y., USA ; The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, New York, N.Y., USA ; The Gertrude H. Sergievsky Center, Columbia University College of Physicians and Surgeons, New York, N.Y., USA ; Division of Epidemiology, Joseph P. Mailman School of Public Health, Columbia University, New York, N.Y., USA., Tang MX; The Gertrude H. Sergievsky Center, Columbia University College of Physicians and Surgeons, New York, N.Y., USA ; Department of Biostatistics, Joseph P. Mailman School of Public Health, Columbia University, New York, N.Y., USA., Zimmerman M; Department of Psychology, Fordham University, Bronx, N.Y., USA., Scarmeas N; Cognitive Neuroscience Division, Department of Neurology, New York, N.Y., USA ; The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, New York, N.Y., USA ; The Gertrude H. Sergievsky Center, Columbia University College of Physicians and Surgeons, New York, N.Y., USA ; Department of Neurology, Columbia University College of Physicians and Surgeons, New York, N.Y., USA ; National and Kapodistrian University of Athens Medical School, Athens, Greece., Stern Y; Cognitive Neuroscience Division, Department of Neurology, New York, N.Y., USA ; The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, New York, N.Y., USA ; The Gertrude H. Sergievsky Center, Columbia University College of Physicians and Surgeons, New York, N.Y., USA ; Department of Neurology, Columbia University College of Physicians and Surgeons, New York, N.Y., USA. |
المصدر: | Dementia and geriatric cognitive disorders extra [Dement Geriatr Cogn Dis Extra] 2015 Jul 10; Vol. 5 (2), pp. 286-95. Date of Electronic Publication: 2015 Jul 10 (Print Publication: 2015). |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Karger Country of Publication: Switzerland NLM ID: 101564825 Publication Model: eCollection Cited Medium: Print ISSN: 1664-5464 (Print) Linking ISSN: 16645464 NLM ISO Abbreviation: Dement Geriatr Cogn Dis Extra Subsets: PubMed not MEDLINE |
أسماء مطبوعة: | Original Publication: Basel : Karger |
مستخلص: | Background/aims: To examine the association between self-reported sleep problems and incidence of dementia in community-dwelling elderly people. Methods: 1,041 nondemented participants over 65 years old were examined longitudinally. Sleep problems were estimated using the RAND Medical Outcomes Study Sleep Scale examining sleep disturbance, snoring, sleep short of breath or with a headache, sleep adequacy, and sleep somnolence. Cox regression analysis was used to examine the association between sleep problems and risk for incident dementia. Age, gender, education, ethnicity, APOE-ε4, stroke, heart disease, hypertension, diabetes, and depression were included as covariates. Results: Over 3 years of follow-up, 966 (92.8%) participants remained nondemented, while 78 (7.2%) developed dementia. In unadjusted models, sleep inadequacy ('Get the amount of sleep you need') at the initial visit was associated with increased risk of incident dementia (HR = 1.20; 95% CI 1.02-1.42; p = 0.027). Adjusting for all the covariates, increased risk of incident dementia was still associated with sleep inadequacy (HR = 1.20; 95% CI 1.01-1.42; p = 0.040), as well as with increased daytime sleepiness ('Have trouble staying awake during the day') (HR = 1.24; 95% CI 1.00-1.54; p = 0.047). Conclusion: Our results suggest that sleep inadequacy and increased daytime sleepiness are risk factors for dementia in older adults, independent of demographic and clinical factors. |
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معلومات مُعتمدة: | Z01 AG007370 United States ImNIH Intramural NIH HHS; K99 AG042483 United States AG NIA NIH HHS; R00 AG042483 United States AG NIA NIH HHS; R01 AG037212 United States AG NIA NIH HHS; R01 AG007370 United States AG NIA NIH HHS |
فهرسة مساهمة: | Keywords: Daytime sleepiness; Dementia; Elderly; Longitudinal study; Sleep adequacy |
تواريخ الأحداث: | Date Created: 20150815 Date Completed: 20150814 Latest Revision: 20220331 |
رمز التحديث: | 20231215 |
مُعرف محوري في PubMed: | PMC4521063 |
DOI: | 10.1159/000431311 |
PMID: | 26273244 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1664-5464 |
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DOI: | 10.1159/000431311 |