دورية أكاديمية
Real-life Data on Patient Characteristics, Cost and Effectiveness of Field-directed Treatment for Actinic Keratoses: An Observational Study.
| العنوان: | Real-life Data on Patient Characteristics, Cost and Effectiveness of Field-directed Treatment for Actinic Keratoses: An Observational Study. |
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| المؤلفون: | van Rijsingen MC; Department of Dermatology, Radboud University Medical Centre, 6500 HB Nijmegen, The Netherlands. Margit.vanRijsingen@radboudumc.nl., Seubring I, Grutters JP, Maessen-Visch MB, Alkemade HA, van Doorn R, Groenewoud H, van de Kerkhof PC, van der Wilt GJ, Gerritsen MJ |
| المصدر: | Acta dermato-venereologica [Acta Derm Venereol] 2016 Mar; Vol. 96 (3), pp. 346-50. |
| نوع المنشور: | Comparative Study; Journal Article; Multicenter Study; Observational Study; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: MJS Publishing Country of Publication: Sweden NLM ID: 0370310 Publication Model: Print Cited Medium: Internet ISSN: 1651-2057 (Electronic) Linking ISSN: 00015555 NLM ISO Abbreviation: Acta Derm Venereol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2024- : Uppsala, Sweden : MJS Publishing Original Publication: Stockholm : Acta dermato-venereologica |
| مواضيع طبية MeSH: | Drug Costs*, Aminolevulinic Acid/*analogs & derivatives , Aminoquinolines/*economics , Aminoquinolines/*therapeutic use , Dermatologic Agents/*economics , Dermatologic Agents/*therapeutic use , Fluorouracil/*economics , Fluorouracil/*therapeutic use , Keratosis, Actinic/*drug therapy , Keratosis, Actinic/*economics , Photochemotherapy/*economics , Photosensitizing Agents/*economics , Photosensitizing Agents/*therapeutic use, Aged ; Aged, 80 and over ; Aminolevulinic Acid/economics ; Aminolevulinic Acid/therapeutic use ; Cost-Benefit Analysis ; Female ; Humans ; Imiquimod ; Male ; Middle Aged ; Netherlands ; Patient Preference ; Photochemotherapy/methods ; Remission Induction ; Severity of Illness Index ; Time Factors ; Treatment Outcome |
| مستخلص: | Actinic keratoses (AK) occur frequently; however, real-life clinical data on personalized treatment choice and costs are scarce. This multicentre one-year observational study investigated patient-characteristics, cost and effectiveness of methylaminolaevulinate photodynamic therapy (MAL-PDT), imiquimod (IMI) and 5-fluorour-acil (5-FU) in patients with AKs on the face/scalp. A total of 104 patients preferred MAL-PDT, 106 preferred IMI and 110 preferred 5-FU. At baseline, significant differences between treatment groups were found; most patients were severely affected (mean 32.5 AK in PDT-group, 20.2 in IMI-group, 22.8 in 5-FU-group). A mean reduction in lesions of 81% after MAL-PDT, 82% after IMI and 88% after 5-FU was found after one year. Annual costs were €1,950 for MAL-PDT, €877 for IMI and €738 for 5-FU. These results show that, compared with clinical trials, in the real-life clinical setting AK patients are usually more severely affected and treatment costs are much higher. Furthermore, patient characteristics are important factors in treatment choice. |
| المشرفين على المادة: | 0 (Aminoquinolines) 0 (Dermatologic Agents) 0 (Photosensitizing Agents) 585NM85KYM (methyl 5-aminolevulinate) 88755TAZ87 (Aminolevulinic Acid) P1QW714R7M (Imiquimod) U3P01618RT (Fluorouracil) |
| تواريخ الأحداث: | Date Created: 20150818 Date Completed: 20161213 Latest Revision: 20181202 |
| رمز التحديث: | 20221213 |
| DOI: | 10.2340/00015555-2216 |
| PMID: | 26280988 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1651-2057 |
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| DOI: | 10.2340/00015555-2216 |