دورية أكاديمية
The making of a Barr body: the mosaic of factors that eXIST on the mammalian inactive X chromosome.
| العنوان: | The making of a Barr body: the mosaic of factors that eXIST on the mammalian inactive X chromosome. |
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| المؤلفون: | Dixon-McDougall T; Department of Medical Genetics, University of British Columbia, Vancouver, BC V6T 1Z3, Canada.; Department of Medical Genetics, University of British Columbia, Vancouver, BC V6T 1Z3, Canada., Brown C; Department of Medical Genetics, University of British Columbia, Vancouver, BC V6T 1Z3, Canada.; Department of Medical Genetics, University of British Columbia, Vancouver, BC V6T 1Z3, Canada. |
| المصدر: | Biochemistry and cell biology = Biochimie et biologie cellulaire [Biochem Cell Biol] 2016 Feb; Vol. 94 (1), pp. 56-70. Date of Electronic Publication: 2015 Jun 24. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Canadian Science Publishing Country of Publication: Canada NLM ID: 8606068 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1208-6002 (Electronic) Linking ISSN: 08298211 NLM ISO Abbreviation: Biochem Cell Biol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2011- : Ottawa, ON : Canadian Science Publishing Original Publication: Ottawa, Ont. : National Research Council of Canada, c1986- |
| مواضيع طبية MeSH: | Gene Silencing* , X Chromosome Inactivation*, Histones/*metabolism , Polycomb-Group Proteins/*metabolism , RNA, Long Noncoding/*metabolism , Sex Chromatin/*metabolism , X Chromosome/*genetics, Acetylation ; Animals ; DNA (Cytosine-5-)-Methyltransferases/metabolism ; DNA Methylation ; DNA-Binding Proteins/metabolism ; Female ; Histone Deacetylases/metabolism ; Humans ; Mice ; RNA, Long Noncoding/genetics ; Sex Chromatin/genetics ; X Chromosome/metabolism |
| مستخلص: | During X-chromosome inactivation (XCI), nearly an entire X chromosome is permanently silenced and converted into a Barr body, providing dosage compensation for eutherians between the sexes. XCI is facilitated by the upregulation of the long non-coding RNA gene, XIST, which coats its chromosome of origin, recruits heterochromatin factors, and silences gene expression. During XCI, at least two distinct types of heterochromatin are established, and in this review we discuss the enrichment of facultative heterochromatin marks such as H3K27me3, H2AK119ub, and macroH2A as well as pericentric heterochromatin marks such as HP1, H3K9me3, and H4K20me3. The extremely stable maintenance of silencing is a product of reinforcing interactions within and between these domains. This paper "Xplores" the current knowledge of the pathways involved in XCI, how the pathways interact, and the gaps in our understanding that need to be filled. |
| فهرسة مساهمة: | Keywords: X-chromosome Inactivation (XCI); XIST; epigenetics; gene silencing; heterochromatin; hétérochromatine; inactivation du chromosome X; silençage génique; épigénétique |
| المشرفين على المادة: | 0 (DNA-Binding Proteins) 0 (Histones) 0 (Polycomb-Group Proteins) 0 (RNA, Long Noncoding) 0 (XIST non-coding RNA) EC 2.1.1.37 (DNA (Cytosine-5-)-Methyltransferases) EC 3.5.1.98 (Histone Deacetylases) |
| تواريخ الأحداث: | Date Created: 20150819 Date Completed: 20160928 Latest Revision: 20220317 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1139/bcb-2015-0016 |
| PMID: | 26283003 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1208-6002 |
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| DOI: | 10.1139/bcb-2015-0016 |