دورية أكاديمية
أعرض في EDS

Diurnal Variation of Hormonal and Lipid Biomarkers in a Molecular Epidemiology-Like Setting.

التفاصيل البيبلوغرافية
العنوان: Diurnal Variation of Hormonal and Lipid Biomarkers in a Molecular Epidemiology-Like Setting.
المؤلفون: van Kerkhof LW; Centre for Health Protection, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands., Van Dycke KC; Centre for Health Protection, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands; Department of Genetics, Center for Biomedical Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands., Jansen EH; Centre for Health Protection, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands., Beekhof PK; Centre for Health Protection, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands., van Oostrom CT; Centre for Health Protection, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands., Ruskovska T; Faculty of Medical Sciences, Goce Delcev University, Stip, Republic of Macedonia., Velickova N; Faculty of Medical Sciences, Goce Delcev University, Stip, Republic of Macedonia., Kamcev N; Faculty of Medical Sciences, Goce Delcev University, Stip, Republic of Macedonia., Pennings JL; Centre for Health Protection, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands., van Steeg H; Centre for Health Protection, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands; Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands., Rodenburg W; Centre for Health Protection, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands.
المصدر: PloS one [PLoS One] 2015 Aug 18; Vol. 10 (8), pp. e0135652. Date of Electronic Publication: 2015 Aug 18 (Print Publication: 2015).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
أسماء مطبوعة: Original Publication: San Francisco, CA : Public Library of Science
مواضيع طبية MeSH: Circadian Rhythm/*genetics , Hormones/*blood , Lipids/*blood, Biomarkers/blood ; Female ; Gene Expression Regulation/physiology ; Humans ; Male ; Molecular Epidemiology ; Young Adult
مستخلص: Introduction: Many molecular epidemiology studies focusing on high prevalent diseases, such as metabolic disorders and cancer, investigate metabolic and hormonal markers. In general, sampling for these markers can occur at any time-point during the day or after an overnight fast. However, environmental factors, such as light exposure and food intake might affect the levels of these markers, since they provide input for the internal time-keeping system. When diurnal variation is larger than the inter-individual variation, time of day should be taken into account. Importantly, heterogeneity in diurnal variation and disturbance of circadian rhythms among a study population might increasingly occur as a result of our increasing 24/7 economy and related variation in exposure to environmental factors (such as light and food).
Aim: The aim of the present study was to determine whether a set of often used biomarkers shows diurnal variation in a setting resembling large molecular epidemiology studies, i.e., non-fasted and limited control possibilities for other environmental influences.
Results: We show that markers for which diurnal variation is not an issue are adrenocorticotropic hormone, follicle stimulating hormone, estradiol and high-density lipoprotein. For all other tested markers diurnal variation was observed in at least one gender (cholesterol, cortisol, dehydroepiandrosterone sulfate, free fatty acids, low-density lipoprotein, luteinizing hormone, prolactin, progesterone, testosterone, triglycerides, total triiodothyronine and thyroid-stimulating hormone) or could not reliably be detected (human growth hormone).
Discussion: Thus, studies investigating these markers should take diurnal variation into account, for which we provide some options. Furthermore, our study indicates the need for investigating diurnal variation (in literature or experimentally) before setting up studies measuring markers in routine and controlled settings, especially since time-of-day likely matters for many more markers than the ones investigated in the present study.
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المشرفين على المادة: 0 (Biomarkers)
0 (Hormones)
0 (Lipids)
تواريخ الأحداث: Date Created: 20150819 Date Completed: 20160513 Latest Revision: 20220408
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC4540433
DOI: 10.1371/journal.pone.0135652
PMID: 26285127
قاعدة البيانات: MEDLINE
الوصف
تدمد:1932-6203
DOI:10.1371/journal.pone.0135652