دورية أكاديمية
أعرض في EDS

Effects of early-life stress on cognitive function and hippocampal structure in female rodents.

التفاصيل البيبلوغرافية
العنوان: Effects of early-life stress on cognitive function and hippocampal structure in female rodents.
المؤلفون: Loi M; Department of Translational Neuroscience, Brain Center Rudolf Magnus, UMC Utrecht, The Netherlands., Mossink JC; Department of Translational Neuroscience, Brain Center Rudolf Magnus, UMC Utrecht, The Netherlands., Meerhoff GF; SILS-Center for Neuroscience, University of Amsterdam, The Netherlands., Den Blaauwen JL; SILS-Center for Neuroscience, University of Amsterdam, The Netherlands., Lucassen PJ; SILS-Center for Neuroscience, University of Amsterdam, The Netherlands. Electronic address: p.j.lucassen@uva.nl., Joëls M; Department of Translational Neuroscience, Brain Center Rudolf Magnus, UMC Utrecht, The Netherlands. Electronic address: m.joels@umcutrecht.nl.
المصدر: Neuroscience [Neuroscience] 2017 Feb 07; Vol. 342, pp. 101-119. Date of Electronic Publication: 2015 Aug 20.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Elsevier Science Country of Publication: United States NLM ID: 7605074 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7544 (Electronic) Linking ISSN: 03064522 NLM ISO Abbreviation: Neuroscience Subsets: MEDLINE
أسماء مطبوعة: Publication: [New York?] : Elsevier Science
Original Publication: Oxford, Elmsford, N. Y., Pergamon Press
مواضيع طبية MeSH: Cognition*/drug effects , Cognition*/physiology , Maternal Deprivation*, Hippocampus/*growth & development , Hippocampus/*pathology , Stress, Psychological/*pathology, Animals ; Animals, Newborn ; Anxiety/etiology ; Anxiety/pathology ; Anxiety/physiopathology ; Anxiety/prevention & control ; Disease Models, Animal ; Female ; Gambling/etiology ; Gambling/pathology ; Gambling/physiopathology ; Gambling/prevention & control ; Hippocampus/drug effects ; Hormone Antagonists/pharmacology ; Memory/drug effects ; Memory/physiology ; Mifepristone/pharmacology ; Neurogenesis/drug effects ; Neurogenesis/physiology ; Neurons/drug effects ; Neurons/pathology ; Random Allocation ; Rats, Wistar ; Receptors, Glucocorticoid/antagonists & inhibitors ; Receptors, Glucocorticoid/metabolism ; Sexual Maturation ; Stress, Psychological/complications ; Stress, Psychological/drug therapy ; Stress, Psychological/physiopathology ; Treatment Failure
مستخلص: We tested the effect of early-life stress (ELS) - 24h maternal deprivation (MD) at postnatal day (PND) 3 - on cognitive performance and hippocampal structure in 12-17-week-old female rats. Behavioral performance was examined in: the Elevated Plus Maze, as an index for general anxiety; the rodent Iowa gambling test, probing reward-based decision making; and the object recognition and object-in-location task, to assess non-stressful contextual memory performance. We further determined hippocampal dentate gyrus (DG) volume and cell density as well as adult proliferation and neurogenesis rates. Half of the rats was treated with the glucocorticoid receptor antagonist mifepristone during a critical pre-pubertal developmental window (PNDs 26-28), in an attempt to ameliorate the potentially adverse behavioral consequences of ELS. Neither MD nor treatment with the glucocorticoid antagonist affected behavioral performance of the females in any of the tasks. Also, DG structure, proliferation and neurogenesis were not different between the groups. Lack of structural differences and a behavioral phenotype in non-stressful hippocampus dependent learning tasks fits with the lack of phenotype generally reported after ELS in female but less so in male rodents. As evident from an extensive literature review, female and male animals appear to respond more similarly to early-life adversity when tested in anxiety-related tasks. This agrees with recent findings in humans suggesting that females may be relatively resilient to the structural/hippocampal effects of childhood maltreatment, but not to the anxiety and mood-related psychopathology for which childhood maltreatment is considered a risk factor.
(Copyright © 2015 IBRO. Published by Elsevier Ltd. All rights reserved.)
فهرسة مساهمة: Keywords: contextual memory; depression; hippocampus; neurogenesis; prefrontal cortex; sex difference
المشرفين على المادة: 0 (Hormone Antagonists)
0 (Receptors, Glucocorticoid)
320T6RNW1F (Mifepristone)
تواريخ الأحداث: Date Created: 20150823 Date Completed: 20170905 Latest Revision: 20180821
رمز التحديث: 20240628
DOI: 10.1016/j.neuroscience.2015.08.024
PMID: 26297897
قاعدة البيانات: MEDLINE
الوصف
تدمد:1873-7544
DOI:10.1016/j.neuroscience.2015.08.024