دورية أكاديمية
Pancreatic cancer patients with lymph node involvement by direct tumor extension have similar survival to those with node-negative disease.
| العنوان: | Pancreatic cancer patients with lymph node involvement by direct tumor extension have similar survival to those with node-negative disease. |
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| المؤلفون: | Williams JL; Department of Surgery, Harbor-UCLA Medical Center, Torrance, California., Nguyen AH; Department of Surgery, David Geffen School of Medicine at UCLA, Los Angeles, California., Rochefort M; Department of Surgery, David Geffen School of Medicine at UCLA, Los Angeles, California., Muthusamy VR; Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California., Wainberg ZA; Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California., Dawson DW; Department of Pathology, David Geffen School of Medicine at UCLA, Los Angeles, California., Tomlinson JS; Department of Surgery, David Geffen School of Medicine at UCLA, Los Angeles, California., Hines OJ; Department of Surgery, David Geffen School of Medicine at UCLA, Los Angeles, California., Reber HA; Department of Surgery, David Geffen School of Medicine at UCLA, Los Angeles, California., Donahue TR; Department of Surgery, David Geffen School of Medicine at UCLA, Los Angeles, California.; Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, California. |
| المصدر: | Journal of surgical oncology [J Surg Oncol] 2015 Sep; Vol. 112 (4), pp. 396-402. Date of Electronic Publication: 2015 Aug 25. |
| نوع المنشور: | Clinical Trial; Comparative Study; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley-Liss Country of Publication: United States NLM ID: 0222643 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-9098 (Electronic) Linking ISSN: 00224790 NLM ISO Abbreviation: J Surg Oncol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2005-> : Hoboken, NJ : Wiley-Liss Original Publication: New York, Plenum. |
| مواضيع طبية MeSH: | Adenocarcinoma/*mortality , Carcinoma, Pancreatic Ductal/*mortality , Lymph Nodes/*pathology , Pancreatectomy/*mortality , Pancreatic Neoplasms/*mortality, Adenocarcinoma/secondary ; Adenocarcinoma/surgery ; Adult ; Aged ; Aged, 80 and over ; Carcinoma, Pancreatic Ductal/secondary ; Carcinoma, Pancreatic Ductal/surgery ; Female ; Follow-Up Studies ; Humans ; Lymph Node Excision ; Lymph Nodes/surgery ; Lymphatic Metastasis ; Male ; Middle Aged ; Neoplasm Grading ; Neoplasm Invasiveness ; Neoplasm Staging ; Pancreatic Neoplasms/pathology ; Pancreatic Neoplasms/surgery ; Prognosis ; Prospective Studies ; Survival Rate ; Young Adult |
| مستخلص: | Background: Lymph node (LN) involvement is a well-known poor prognostic factor in patients with pancreatic ductal adenocarcinoma (PDAC). However, there have been conflicting results on the significance of the mechanism of LN involvement, "direct" tumor invasion versus "metastatic," disease on patient survival. Methods: Clinicopathologic records from all patients who underwent resection for PDAC from 1990 to 2014 at a single-institution were reviewed. Results: Of the 385 total patients, there was tumor invasion outside of the pancreas in 289 (75.1%) patients. Overall, 239 (62.1%) had node-positive disease: 220 (92.0%) by "metastatic" involvement, 14 (5.9%) by "direct" tumor extension, and five (2.1%) by a mix of "metastatic" and "direct". There were no significant differences in clinicopathologic factors associated with PDAC survival between "metastatic" and "direct" LN patients. The median overall survival for the whole cohort was 31.1 months. Compared to overall survival in patients with LN-negative disease (median 40.7 months), those with LNs involved by "metastatic" spread was significantly shorter (median 25.7 months, P < 0.001), yet "direct" LN extension was similar (median 48.1 months, P = 0.719). Conclusions: The mechanism of LN involvement affects PDAC prognosis. Patients with LNs involved by direct extension have similar survival to those with node-negative disease. (© 2015 Wiley Periodicals, Inc.) |
| فهرسة مساهمة: | Keywords: TNM staging; neoplasm metastasis; pancreatic cancer |
| تواريخ الأحداث: | Date Created: 20150826 Date Completed: 20160105 Latest Revision: 20150925 |
| رمز التحديث: | 20240513 |
| DOI: | 10.1002/jso.24011 |
| PMID: | 26303811 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1096-9098 |
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| DOI: | 10.1002/jso.24011 |