دورية أكاديمية
Basic mechanisms of longevity: A case study of Drosophila pro-longevity genes.
| العنوان: | Basic mechanisms of longevity: A case study of Drosophila pro-longevity genes. |
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| المؤلفون: | Proshkina EN; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia; Institute of Biology of Komi Science Center of Ural Branch of RAS, 167982 Syktyvkar, Russia., Shaposhnikov MV; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia; Institute of Biology of Komi Science Center of Ural Branch of RAS, 167982 Syktyvkar, Russia., Sadritdinova AF; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia., Kudryavtseva AV; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia., Moskalev AA; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia. Electronic address: amoskalev@ib.komisc.ru. |
| المصدر: | Ageing research reviews [Ageing Res Rev] 2015 Nov; Vol. 24 (Pt B), pp. 218-31. Date of Electronic Publication: 2015 Aug 28. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Country of Publication: England NLM ID: 101128963 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-9649 (Electronic) Linking ISSN: 15681637 NLM ISO Abbreviation: Ageing Res Rev Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Oxford, UK : Elsevier Science, c2002- |
| مواضيع طبية MeSH: | Aging/*physiology , Drosophila Proteins/*genetics , Longevity/*genetics, Animals ; Drosophila melanogaster ; Humans |
| مستخلص: | Drosophila is one of the most convenient model organisms in the genetics of aging and longevity. Unlike the nematodes, which allow for the detection of new pro-aging genes by knockout and RNAi-mediated knock-down, Drosophila also provides an opportunity to find new pro-longevity genes by driver-induced overexpression. Similar studies on other models are extremely rare. In this review, we focused on genes whose overexpression prolongs the life of fruit flies. The majority of longevity-associated genes regulates metabolism and stress resistance, and belongs to the IGF-1R, PI3K, PKB, AMPK and TOR metabolic regulation cluster and the FOXO, HDAC, p53 stress response cluster. (Copyright © 2015 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Drosophila melanogaster; Overexpression; Pro-longevity genes |
| المشرفين على المادة: | 0 (Drosophila Proteins) |
| تواريخ الأحداث: | Date Created: 20150831 Date Completed: 20161213 Latest Revision: 20161230 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1016/j.arr.2015.08.005 |
| PMID: | 26318059 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1872-9649 |
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| DOI: | 10.1016/j.arr.2015.08.005 |