دورية أكاديمية
أعرض في EDS

Thyroid hormone modulates neuroglobin and cytoglobin in rat brain.

التفاصيل البيبلوغرافية
العنوان: Thyroid hormone modulates neuroglobin and cytoglobin in rat brain.
المؤلفون: Oliveira KC; Department Morphology and Physiology, Faculdade de Medicina do ABC, Santo Andre, SP, Brazil.; Department Medicine, Universidade Federal de Sao Paulo (UNIFESP), Rua Pedro de Toledo, Vila Clementino, Sao Paulo, SP, 04039032, Brazil., da Conceição RR; Department Medicine, Universidade Federal de Sao Paulo (UNIFESP), Rua Pedro de Toledo, Vila Clementino, Sao Paulo, SP, 04039032, Brazil., Piedade GC; Department Physiology and Biophysics, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, Sao Paulo, SP, Brazil., de Souza JS; Department Medicine, Universidade Federal de Sao Paulo (UNIFESP), Rua Pedro de Toledo, Vila Clementino, Sao Paulo, SP, 04039032, Brazil., Sato MA; Department Morphology and Physiology, Faculdade de Medicina do ABC, Santo Andre, SP, Brazil., de Barros Maciel RM; Department Medicine, Universidade Federal de Sao Paulo (UNIFESP), Rua Pedro de Toledo, Vila Clementino, Sao Paulo, SP, 04039032, Brazil., Giannocco G; Department Morphology and Physiology, Faculdade de Medicina do ABC, Santo Andre, SP, Brazil. ggiannocco@gmail.com.; Department Medicine, Universidade Federal de Sao Paulo (UNIFESP), Rua Pedro de Toledo, Vila Clementino, Sao Paulo, SP, 04039032, Brazil. ggiannocco@gmail.com.; Department Biological Sciences, Universidade Federal de Sao Paulo, Diadema, SP, Brazil. ggiannocco@gmail.com.
المصدر: Metabolic brain disease [Metab Brain Dis] 2015 Dec; Vol. 30 (6), pp. 1401-8. Date of Electronic Publication: 2015 Sep 03.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Springer Country of Publication: United States NLM ID: 8610370 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-7365 (Electronic) Linking ISSN: 08857490 NLM ISO Abbreviation: Metab Brain Dis Subsets: MEDLINE
أسماء مطبوعة: Publication: 2005- : Amsterdam : Springer
Original Publication: New York : Plenum, c1986-
مواضيع طبية MeSH: Brain Chemistry/*physiology , Globins/*biosynthesis , Globins/*genetics , Nerve Tissue Proteins/*biosynthesis , Nerve Tissue Proteins/*genetics , Thyroid Hormones/*physiology, Animals ; Brain Chemistry/drug effects ; Cerebellum/metabolism ; Cerebral Cortex/metabolism ; Cytoglobin ; Hippocampus/metabolism ; Male ; Neuroglobin ; Rats ; Rats, Wistar ; Thyroid Hormones/blood ; Thyroid Hormones/pharmacology ; Thyroidectomy ; Triiodothyronine/pharmacology
مستخلص: Thyroid hormones (THs) are essential and crucial for brain development, playing a role in growth and differentiation. Two globins named neuroglobin (Ngb) and cytoglobin (Cygb) are located in the brain, and each one has different distribution and function: They seem to have similar action by providing O(2) for respiratory chain, and detoxification of reactive oxygen species (ROS) and nitric oxide (NO) protecting tissues against irreversible lesions. We aimed to investigate the influence of thyroid state in Ngb and Cygb metabolism in different brain regions and evaluate their responses in cerebellum, hippocampus and cerebral cortex (hereafter called as cortex) after supraphysiological doses at different time points of TH administration. Experiments were carried out in rats, divided in eight experimental groups Control (C), thyroidectomy (Tx), and thyroidectomy treated with jugular intravenous injection (i.v). T3 (100 μl/100 g) injection and sacrificed after 30, 60, 120 min and 6, 12 and 24 h. In cortex, we found increase in Ngb gene and protein expression in different time points compared to C group, however Cygb gene and protein expression were decreased. In hippocampus, Ngb and Cygb protein expression increased 24 h after i.v. T3 injection in comparison to Tx. In cerebellum, we found increased Ngb gene expression after 120 min, 6, 12 and 24 h after T3 administration compared to Tx, and in contrast, protein expression was found to be significantly increased only 12 and 24 h compared to Tx. Ngb and Cygb expression in brain is influenced by thyroid hormone state both by its lack or excess.
References: Nature. 2000 Sep 28;407(6803):461-2. (PMID: 11028983)
Antioxid Redox Signal. 2010 Sep 15;13(6):769-81. (PMID: 20367258)
Mol Biol Evol. 2002 Apr;19(4):416-21. (PMID: 11919282)
Endocrinology. 1993 Aug;133(2):467-73. (PMID: 8344193)
Nature. 1970 Aug 15;227(5259):680-5. (PMID: 5432063)
Mol Med Rep. 2008 May-Jun;1(3):279-95. (PMID: 21479409)
Brain Res Mol Brain Res. 1996 Dec;42(2):227-35. (PMID: 9013778)
Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21570-5. (PMID: 21115824)
Int J Dev Neurosci. 2007 May;25(3):171-9. (PMID: 17408906)
Mol Cell Endocrinol. 2004 Oct 29;226(1-2):19-26. (PMID: 15489001)
Endocrinology. 2006 Dec;147(12):5777-85. (PMID: 16990344)
Trends Neurosci. 2000 Jun;23 (6):265-71. (PMID: 10838596)
J Biol Chem. 1991 Dec 5;266(34):23226-32. (PMID: 1720778)
Neurosci Lett. 2003 Jul 31;346(1-2):114-6. (PMID: 12850561)
Neurosci Lett. 2013 Feb 8;534:333-7. (PMID: 23182882)
Biochem Biophys Res Commun. 2002 Feb 8;290(5):1411-9. (PMID: 11820779)
Brain Res. 2015 Mar 19;1601:52-63. (PMID: 25591482)
Nature. 2000 Sep 28;407(6803):520-3. (PMID: 11029004)
Brain Struct Funct. 2013 Mar;218(2):603-9. (PMID: 23160832)
Adv Exp Med Biol. 2007;618:169-80. (PMID: 18269196)
J Clin Endocrinol Metab. 2005 Feb;90(2):936-43. (PMID: 15507505)
Neurosci Res. 2001 Jul;40(3):273-9. (PMID: 11448519)
Mol Endocrinol. 1991 Feb;5(2):273-80. (PMID: 1710032)
J Cereb Blood Flow Metab. 2012 Mar;32(3):525-36. (PMID: 22086197)
J Neurosci Res. 2008 Nov 1;86(14):3117-25. (PMID: 18543341)
Proc Natl Acad Sci U S A. 1999 Aug 31;96(18):10092-7. (PMID: 10468567)
Curr Opin Pharmacol. 2008 Feb;8(1):20-4. (PMID: 17942367)
Science. 1981 Oct 30;214(4520):571-3. (PMID: 7291997)
J Neuroendocrinol. 2010 Mar;22(3):153-65. (PMID: 20041985)
Neuroscience. 2002;115(3):645-56. (PMID: 12435404)
Endocr Rev. 1987 Aug;8(3):288-308. (PMID: 3308445)
Proc Natl Acad Sci U S A. 2001 Dec 18;98(26):15306-11. (PMID: 11742077)
Thyroid. 2006 Mar;16(3):211-6. (PMID: 16571082)
J Biol Chem. 1951 Nov;193(1):265-75. (PMID: 14907713)
Neurology. 1998 Mar;50(3):599-603. (PMID: 9521242)
News Physiol Sci. 2004 Jun;19:110-3. (PMID: 15143204)
Proc Natl Acad Sci U S A. 2006 Nov 21;103(47):17944-8. (PMID: 17098866)
Reprod Nutr Dev. 1982;22(1B):201-8. (PMID: 7156476)
Proc Natl Acad Sci U S A. 2003 Mar 18;100(6):3497-500. (PMID: 12621155)
Gene. 2007 Aug 15;398(1-2):114-22. (PMID: 17532579)
Endocrinology. 2008 May;149(5):2241-50. (PMID: 18239067)
فهرسة مساهمة: Keywords: Cerebellum; Cerebral cortex; Cytoglobin; Hippocampus; Neuroglobin; Thyroid hormones
المشرفين على المادة: 0 (Cygb protein, rat)
0 (Cytoglobin)
0 (Nerve Tissue Proteins)
0 (Neuroglobin)
0 (Thyroid Hormones)
06LU7C9H1V (Triiodothyronine)
9004-22-2 (Globins)
تواريخ الأحداث: Date Created: 20150904 Date Completed: 20160823 Latest Revision: 20181202
رمز التحديث: 20221213
DOI: 10.1007/s11011-015-9718-5
PMID: 26334191
قاعدة البيانات: MEDLINE
الوصف
تدمد:1573-7365
DOI:10.1007/s11011-015-9718-5