دورية أكاديمية
Rhizopus arrhizus and Fusarium solani Concomitant Infection in an Immunocompromised Host.
| العنوان: | Rhizopus arrhizus and Fusarium solani Concomitant Infection in an Immunocompromised Host. |
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| المؤلفون: | de Almeida Júnior JN; Laboratory of Medical Mycology (LIM-53), Division of Dermatology Clinic, Hospital das Clínicas da FMUSP and Instituto de Medicina Tropical de São Paulo, Universidade de São Paulo, São Paulo, Brazil. jnaj99@gmail.com.; Central Laboratory Division (LIM-03), Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Av. Dr. Enéas de Carvalho Aguiar, 255 - Cerqueira César, São Paulo, 05403-000, Brazil. jnaj99@gmail.com., Ibrahim KY; Infection Control Division, Instituto do Câncer do Estado de São Paulo, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil., Del Negro GM; Laboratory of Medical Mycology (LIM-53), Division of Dermatology Clinic, Hospital das Clínicas da FMUSP and Instituto de Medicina Tropical de São Paulo, Universidade de São Paulo, São Paulo, Brazil., Bezerra ED; Hemathology Department, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil., Duarte Neto AN; Pathology Department, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil., Batista MV; Infectious Diseases Division, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil., Siciliano RF; Cardiology Institute, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil., Giudice MC; Laboratory of Medical Mycology (LIM-53), Division of Dermatology Clinic, Hospital das Clínicas da FMUSP and Instituto de Medicina Tropical de São Paulo, Universidade de São Paulo, São Paulo, Brazil., Motta AL; Central Laboratory Division (LIM-03), Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Av. Dr. Enéas de Carvalho Aguiar, 255 - Cerqueira César, São Paulo, 05403-000, Brazil., Rossi F; Central Laboratory Division (LIM-03), Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Av. Dr. Enéas de Carvalho Aguiar, 255 - Cerqueira César, São Paulo, 05403-000, Brazil., Pierrotti LC; Infection Control Division, Instituto do Câncer do Estado de São Paulo, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil., Freire MP; Infection Control Division, Instituto do Câncer do Estado de São Paulo, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil., Bellesso M; Hemathology Department, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil., Pereira J; Hemathology Department, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil., Abdala E; Infection Control Division, Instituto do Câncer do Estado de São Paulo, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.; Infectious Diseases Division, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil., Benard G; Laboratory of Medical Mycology (LIM-53), Division of Dermatology Clinic, Hospital das Clínicas da FMUSP and Instituto de Medicina Tropical de São Paulo, Universidade de São Paulo, São Paulo, Brazil. |
| المصدر: | Mycopathologia [Mycopathologia] 2016 Feb; Vol. 181 (1-2), pp. 125-9. Date of Electronic Publication: 2015 Sep 07. |
| نوع المنشور: | Case Reports; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Kluwer Academic Country of Publication: Netherlands NLM ID: 7505689 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-0832 (Electronic) Linking ISSN: 0301486X NLM ISO Abbreviation: Mycopathologia Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Dordrecht : Kluwer Academic Original Publication: [The Hague, W. Junk] |
| مواضيع طبية MeSH: | Fusariosis/*complications , Fusariosis/*diagnosis , Fusarium/*isolation & purification , Mucormycosis/*complications , Mucormycosis/*diagnosis , Rhizopus/*isolation & purification, Fungemia/complications ; Fungemia/diagnosis ; Fungemia/microbiology ; Fungemia/pathology ; Fusariosis/microbiology ; Fusariosis/pathology ; Fusarium/genetics ; Humans ; Immunocompromised Host ; Leukemia, Myeloid, Acute/complications ; Male ; Middle Aged ; Mucormycosis/microbiology ; Mucormycosis/pathology ; Neutropenia/complications ; Pathology, Molecular ; Polymerase Chain Reaction ; Rhizopus/genetics ; Sinusitis/complications ; Sinusitis/diagnosis ; Sinusitis/microbiology ; Sinusitis/pathology |
| مستخلص: | Neutropenic patients are at risk of the development of hyalohyphomycosis and mucormycosis. Correct identification is essential for the initiation of the specific treatment, but concomitant mold infections are rarely reported. We report one unprecedented case of concomitant mucormycosis and fusariosis in a neutropenic patient with acute myeloid leukemia. The patient developed rhino-orbital infection by Rhizopus arrhizus and disseminated infection by Fusarium solani. The first culture from a sinus biopsy grew Rhizopus, which was consistent with the histopathology report of mucormycosis. A second sinus biopsy collected later during the patient's clinical deterioration was reported as hyalohyphomycosis, and the culture yielded F. solani. Due to the discordant reports, the second biopsy was reviewed and two hyphae types suggestive of both hyalohyphomycetes and mucormycetes were found. The dual mold infection was confirmed by PCR assays from paraffinized tissue sections. Increased awareness of the existence of dual mold infections in at-risk patients is necessary. PCR methods in tissue sections may increase the diagnosis of dual mold infections. In case of sequential biopsies showing discrepant results, mixed infections have to be suspected. |
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| فهرسة مساهمة: | Keywords: Fusarium solani; Neutropenia; PCR methods; Paraffin-embedded tissue section; Rhizopus arrhizus |
| تواريخ الأحداث: | Date Created: 20150909 Date Completed: 20161005 Latest Revision: 20181113 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1007/s11046-015-9936-8 |
| PMID: | 26346377 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1573-0832 |
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| DOI: | 10.1007/s11046-015-9936-8 |