دورية أكاديمية
Hopanoids as functional analogues of cholesterol in bacterial membranes.
| العنوان: | Hopanoids as functional analogues of cholesterol in bacterial membranes. |
|---|---|
| المؤلفون: | Sáenz JP; Max Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany; saenz@mpi-cbg.de simons@mpi-cbg.de., Grosser D; Max Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany;, Bradley AS; Department of Earth and Planetary Sciences, Washington University, St. Louis, MO 63130;, Lagny TJ; Max Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany;, Lavrynenko O; Max Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany;, Broda M; Max Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany; Department of Biotechnology, University of Wroclaw, 50-383 Wroclaw, Poland., Simons K; Max Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany; saenz@mpi-cbg.de simons@mpi-cbg.de. |
| المصدر: | Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2015 Sep 22; Vol. 112 (38), pp. 11971-6. Date of Electronic Publication: 2015 Sep 08. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
| اللغة: | English |
| بيانات الدورية: | Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Washington, DC : National Academy of Sciences |
| مواضيع طبية MeSH: | Cholesterol/*metabolism , Lipids/*chemistry , Methylobacterium extorquens/*metabolism, Biological Transport ; Cell Membrane/metabolism ; Energy Metabolism ; Lipid A/metabolism ; Phospholipids/chemistry ; Phospholipids/metabolism ; Triterpenes/chemistry ; Triterpenes/metabolism |
| مستخلص: | The functionality of cellular membranes relies on the molecular order imparted by lipids. In eukaryotes, sterols such as cholesterol modulate membrane order, yet they are not typically found in prokaryotes. The structurally similar bacterial hopanoids exhibit similar ordering properties as sterols in vitro, but their exact physiological role in living bacteria is relatively uncharted. We present evidence that hopanoids interact with glycolipids in bacterial outer membranes to form a highly ordered bilayer in a manner analogous to the interaction of sterols with sphingolipids in eukaryotic plasma membranes. Furthermore, multidrug transport is impaired in a hopanoid-deficient mutant of the gram-negative Methylobacterium extorquens, which introduces a link between membrane order and an energy-dependent, membrane-associated function in prokaryotes. Thus, we reveal a convergence in the architecture of bacterial and eukaryotic membranes and implicate the biosynthetic pathways of hopanoids and other order-modulating lipids as potential targets to fight pathogenic multidrug resistance. |
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| فهرسة مساهمة: | Keywords: Methylobacterium; hopanoids; membrane order; multidrug efflux; outer membrane |
| المشرفين على المادة: | 0 (Lipid A) 0 (Lipids) 0 (Phospholipids) 0 (Triterpenes) 1721-59-1 (diplopterol) 97C5T2UQ7J (Cholesterol) |
| تواريخ الأحداث: | Date Created: 20150910 Date Completed: 20151221 Latest Revision: 20181113 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC4586864 |
| DOI: | 10.1073/pnas.1515607112 |
| PMID: | 26351677 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1091-6490 |
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| DOI: | 10.1073/pnas.1515607112 |