دورية أكاديمية
REM sleep behavior disorder, as assessed by questionnaire, in G2019S LRRK2 mutation PD and carriers.
العنوان: | REM sleep behavior disorder, as assessed by questionnaire, in G2019S LRRK2 mutation PD and carriers. |
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المؤلفون: | Saunders-Pullman R; Department of Neurology, Mount Sinai Beth Israel Medical Center, New York, New York, USA.; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Alcalay RN; Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA.; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY, USA., Mirelman A; Movement Disorders Unit, Department of Neurology, Tel-Aviv Medical Center, Sieratzki Chair of Neurology, Department of Neurology and Neurosurgery, Sackler School of Medicine, Sagol School of Neuroscience, Tel-Aviv University, Tel-Aviv, Israel., Wang C; Department of Epidemiology and Social Medicine, Albert Einstein College of Medicine, Bronx, New York, USA., Luciano MS; Department of Neurology, University of California San Francisco, San Francisco, California, USA., Ortega RA; Department of Neurology, Mount Sinai Beth Israel Medical Center, New York, New York, USA., Glickman A; Department of Neurology, Mount Sinai Beth Israel Medical Center, New York, New York, USA., Raymond D; Department of Neurology, Mount Sinai Beth Israel Medical Center, New York, New York, USA., Mejia-Santana H; Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA., Doan N; Department of Neurology, Mount Sinai Beth Israel Medical Center, New York, New York, USA., Johannes B; Department of Neurology, Mount Sinai Beth Israel Medical Center, New York, New York, USA., Yasinovsky K; Movement Disorders Unit, Department of Neurology, Tel-Aviv Medical Center, Sieratzki Chair of Neurology, Department of Neurology and Neurosurgery, Sackler School of Medicine, Sagol School of Neuroscience, Tel-Aviv University, Tel-Aviv, Israel., Ozelius L; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Genetics, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Clark L; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY, USA.; Department of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, New York, USA., Orr-Utreger A; Genetic Institute, Tel-Aviv Medical Center, Sackler School of Medicine, Sagol School of Neuroscience, Tel-Aviv University, Tel-Aviv, Israel., Marder K; Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA.; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY, USA.; Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, New York, USA.; Department of Psychiatry, Columbia University Medical Center, New York, New York, USA., Giladi N; Movement Disorders Unit, Department of Neurology, Tel-Aviv Medical Center, Sieratzki Chair of Neurology, Department of Neurology and Neurosurgery, Sackler School of Medicine, Sagol School of Neuroscience, Tel-Aviv University, Tel-Aviv, Israel., Bressman SB; Department of Neurology, Mount Sinai Beth Israel Medical Center, New York, New York, USA.; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. |
مؤلفون مشاركون: | AJ LRRK2 Consortium |
المصدر: | Movement disorders : official journal of the Movement Disorder Society [Mov Disord] 2015 Nov; Vol. 30 (13), pp. 1834-9. Date of Electronic Publication: 2015 Sep 14. |
نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: Wiley-Liss Country of Publication: United States NLM ID: 8610688 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1531-8257 (Electronic) Linking ISSN: 08853185 NLM ISO Abbreviation: Mov Disord Subsets: MEDLINE |
أسماء مطبوعة: | Publication: <2001->: New York, NY : Wiley-Liss Original Publication: [New York, N.Y.] : Raven Press, [c1986- |
مواضيع طبية MeSH: | Surveys and Questionnaires*, Glutamine/*genetics , Mutation/*genetics , Parkinson Disease/*diagnosis , Parkinson Disease/*genetics , Protein Serine-Threonine Kinases/*genetics , Serine/*genetics , Sleep Deprivation/*genetics, Adult ; Aged ; Female ; Humans ; Judaism ; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 ; Male ; Middle Aged ; Sleep Deprivation/diagnosis |
مستخلص: | Background: Rapid eye movement sleep behavior disorder occurs with idiopathic Parkinson's disease (PD) and often precedes PD. Its frequency in LRRK2-PD and utility as a preclinical marker has not been established. Methods: One hundred forty-four idiopathic PD, 142 LRRK2 G2019S mutation PD, 117 non-manifesting carriers, 93 related noncarriers, and 40 healthy controls completed the Rapid eye movement sleep Behavior Disorder Screening Questionnaire. Results: Cut scores were met by 30.6% idiopathic PD, 19.7% LRRK2-PD, 6% nonmanifesting carriers, 20.4% related noncarriers, and 15% controls. The likelihood of abnormal scores was decreased in LRRK2-PD versus idiopathic PD (odds ratio = 0.55, P = 0.03), nonmanifesting carriers versus related noncarriers (OR = 0.25, P < 0.01), and PD of less than 3 years' duration, 1 of 19 LRRK2-PD versus 14 of 41 idiopathic PD (P < 0.05). Conclusions: A lower frequency of abnormal questionnaire scores is seen in LRRK2-PD, especially in early LRRK2-PD, and in nonmanifesting carriers. Therefore, the Rapid eye movement sleep Behavior Disorder Questionnaire is unlikely to serve as a preclinical marker for phenoconversion to PD. (© 2015 International Parkinson and Movement Disorder Society.) |
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معلومات مُعتمدة: | K02 NS080915 United States NS NINDS NIH HHS; P50 NS038370 United States NS NINDS NIH HHS; P50 AG008702 United States AG NIA NIH HHS; K02 NS073836 United States NS NINDS NIH HHS; R01 NS060113 United States NS NINDS NIH HHS; R01 NS073872 United States NS NINDS NIH HHS; K02-NS073836 United States NS NINDS NIH HHS; UL1 TR000040 United States TR NCATS NIH HHS; R56 NS036630 United States NS NINDS NIH HHS; P01 NS037409 United States NS NINDS NIH HHS; U01 NS052592 United States NS NINDS NIH HHS; UL1 RR024156 United States RR NCRR NIH HHS; R21 NS050487 United States NS NINDS NIH HHS; NINDS 10628097 United States PHS HHS; R21 NS075881 United States NS NINDS NIH HHS; R01 NS036630 United States NS NINDS NIH HHS; R01 DC011805 United States DC NIDCD NIH HHS |
فهرسة مساهمة: | Investigator: VL Shanker; M Groves; C Palmese; E Deegan; A Drobnis; J Ratliff; L Severt; N Lubarr; R Sachdev; A Pomerantz; S Fahn; L Cote; P Greene; C Waters; P Mazzoni; O Levy; MX Tang; B Rakitin; E Roos; MO Riley; L Rosado; C Moskowitz; T Dorovski; X Liu; S Kisselev; I Peer; V Vacic; Y Balash; S Hertzel; A Hillel; H Kobo; N Bregman; M Kestenbaum; T Hendler; H Lehrman; EE Sapir; M Zelis; M Shtaigman; E Shimony; M Victor; M Grumberg; O Assais Keywords: LRRK2; Parkinson's disease; RBDSQ; REM Behavior Disorder; preclinical |
المشرفين على المادة: | 0RH81L854J (Glutamine) 452VLY9402 (Serine) EC 2.7.11.1 (LRRK2 protein, human) EC 2.7.11.1 (Leucine-Rich Repeat Serine-Threonine Protein Kinase-2) EC 2.7.11.1 (Protein Serine-Threonine Kinases) |
تواريخ الأحداث: | Date Created: 20150915 Date Completed: 20161012 Latest Revision: 20240610 |
رمز التحديث: | 20240610 |
مُعرف محوري في PubMed: | PMC4715645 |
DOI: | 10.1002/mds.26413 |
PMID: | 26366513 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1531-8257 |
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DOI: | 10.1002/mds.26413 |