دورية أكاديمية
Administration of tenofovir disoproxil fumarate-based antiretroviral therapy in an HIV-infected patient following unilateral nephrectomy.
| العنوان: | Administration of tenofovir disoproxil fumarate-based antiretroviral therapy in an HIV-infected patient following unilateral nephrectomy. |
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| المؤلفون: | Biagi M; College of Pharmacy, University of Illinois at Chicago, Chicago, IL, USA., Badowski M; Section of Infectious Diseases Pharmacotherapy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL, USA badowski@uic.edu., Chiampas T; Section of Infectious Diseases Pharmacotherapy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL, USA., Young J; Section of Infectious Diseases Pharmacotherapy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL, USA., Vaughn P; Department of Medicine, Section of Infectious Diseases, College of Medicine, University of Illinois at Chicago, Chicago, IL, USA., Shicker L; Illinois Department of Corrections, Chicago, IL, USA., Patel M; Department of Medicine, Section of Infectious Diseases, College of Medicine, University of Illinois at Chicago, Chicago, IL, USA. |
| المصدر: | International journal of STD & AIDS [Int J STD AIDS] 2016 Aug; Vol. 27 (9), pp. 808-11. Date of Electronic Publication: 2015 Sep 16. |
| نوع المنشور: | Case Reports; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Sage Country of Publication: England NLM ID: 9007917 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1758-1052 (Electronic) Linking ISSN: 09564624 NLM ISO Abbreviation: Int J STD AIDS Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Dec. 2012- : London : Sage Original Publication: London, U.K. : Royal Society of Medicine Services, c1990- |
| مواضيع طبية MeSH: | Anti-HIV Agents/*adverse effects , Anti-HIV Agents/*therapeutic use , Glomerular Filtration Rate/*drug effects , HIV Infections/*drug therapy , Kidney/*drug effects , Tenofovir/*therapeutic use, Adenine/adverse effects ; HIV-1/drug effects ; Humans ; Male ; Middle Aged ; Nephrectomy ; Treatment Outcome |
| مستخلص: | We report the use of efavirenz 600 mg/emtricitabine 200 mg/tenofovir disoproxil fumarate 300 mg, once daily in a 47-year-old black man with a solitary kidney and human immunodeficiency virus (HIV). In 1990, he underwent radiation, chemotherapy, and ultimately, a unilateral nephrectomy for Wilms' tumor. Because of previous reports of tenofovir disoproxil fumarate-induced nephrotoxicity, our objective was to evaluate and monitor our patient's renal function over the course of 19 months based on serum creatinine, estimated creatinine clearance using the Cockroft-Gault equation, estimated glomerular filtration rate using the modification of diet in renal disease formula and urinalyses. After experiencing gastrointestinal side effects from other antiretroviral agents, our patient was switched to efavirenz/emtricitabine/tenofovir disoproxil fumarate in June 2013. At baseline, his serum creatinine was 1.35 mg/dL, estimated creatinine clearance 68.7 mL/min (based on actual body weight of 71.8 kg), estimated glomerular filtration rate 72.9 mL/min/1.73 m(2), with a CD4 cell count of 119 cells/mm(3) (5%) and an undetectable HIV viral load. In March 2015, his weight was 73.2 kg, serum creatinine 1.42 mg/dL, estimated creatinine clearance 65.2 mL/min, estimated glomerular filtration rate 68.1 mL/min/1.73 m(2), with a CD4 cell count of 120 cells/mm(3) (10%) and an undetectable HIV viral load. Other authors have reported tenofovir-induced nephrotoxicity in patients with a solitary kidney. Our patient had no evidence of nephrotoxicity over the course of 19 months on tenofovir disoproxil fumarate-based antiretroviral therapy (ART). He maintained adequate renal function, comparable to his baseline renal function. Our case report suggests that a tenofovir disoproxil fumurate-based ART may be a viable option for some patients with a solitary kidney. Additional studies and data are needed considering this is a small and relatively unstudied population. (© The Author(s) 2016.) |
| فهرسة مساهمة: | Keywords: AIDS; HAART; HIV; antiretroviral therapy; renal toxicity; solitary kidney; tenofovir; treatment |
| المشرفين على المادة: | 0 (Anti-HIV Agents) 99YXE507IL (Tenofovir) JAC85A2161 (Adenine) |
| تواريخ الأحداث: | Date Created: 20150918 Date Completed: 20170717 Latest Revision: 20171215 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1177/0956462415599666 |
| PMID: | 26378193 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1758-1052 |
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| DOI: | 10.1177/0956462415599666 |