دورية أكاديمية
أعرض في EDS

Durable sequence stability and bone marrow tropism in a macaque model of human pegivirus infection.

التفاصيل البيبلوغرافية
العنوان: Durable sequence stability and bone marrow tropism in a macaque model of human pegivirus infection.
المؤلفون: Bailey AL; Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, WI 53711, USA. Wisconsin National Primate Research Center, Madison, WI 53711, USA., Lauck M; Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, WI 53711, USA. Wisconsin National Primate Research Center, Madison, WI 53711, USA., Mohns M; Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, WI 53711, USA. Wisconsin National Primate Research Center, Madison, WI 53711, USA., Peterson EJ; Wisconsin National Primate Research Center, Madison, WI 53711, USA., Beheler K; Wisconsin National Primate Research Center, Madison, WI 53711, USA., Brunner KG; Wisconsin National Primate Research Center, Madison, WI 53711, USA., Crosno K; Wisconsin National Primate Research Center, Madison, WI 53711, USA., Mejia A; Wisconsin National Primate Research Center, Madison, WI 53711, USA., Mutschler J; Wisconsin National Primate Research Center, Madison, WI 53711, USA. Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, WI 53711, USA., Gehrke M; Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, WI 53711, USA. Wisconsin National Primate Research Center, Madison, WI 53711, USA., Greene J; Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, WI 53711, USA. Wisconsin National Primate Research Center, Madison, WI 53711, USA., Ericsen AJ; Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, WI 53711, USA. Wisconsin National Primate Research Center, Madison, WI 53711, USA., Weiler A; Wisconsin National Primate Research Center, Madison, WI 53711, USA. Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, WI 53711, USA., Lehrer-Brey G; Wisconsin National Primate Research Center, Madison, WI 53711, USA. Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, WI 53711, USA., Friedrich TC; Wisconsin National Primate Research Center, Madison, WI 53711, USA. Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, WI 53711, USA., Sibley SD; Wisconsin National Primate Research Center, Madison, WI 53711, USA. Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, WI 53711, USA., Kallas EG; Division of Clinical Immunology and Allergy, School of Medicine, University of São Paulo, São Paulo 01310-911, Brazil., Capuano S 3rd; Wisconsin National Primate Research Center, Madison, WI 53711, USA., Rogers J; Wisconsin National Primate Research Center, Madison, WI 53711, USA. Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA., Goldberg TL; Wisconsin National Primate Research Center, Madison, WI 53711, USA. Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, WI 53711, USA., Simmons HA; Wisconsin National Primate Research Center, Madison, WI 53711, USA., O'Connor DH; Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, WI 53711, USA. Wisconsin National Primate Research Center, Madison, WI 53711, USA. doconnor@primate.wisc.edu.
المصدر: Science translational medicine [Sci Transl Med] 2015 Sep 16; Vol. 7 (305), pp. 305ra144.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Washington, DC : American Association for the Advancement of Science
مواضيع طبية MeSH: Disease Models, Animal* , GB virus C* , Viral Tropism*, Bone Marrow/*virology , Flaviviridae Infections/*complications, Acquired Immunodeficiency Syndrome/prevention & control ; Animals ; Bone Marrow/pathology ; Evolution, Molecular ; Female ; Genetic Variation ; HIV Infections/virology ; High-Throughput Nucleotide Sequencing ; Humans ; Likelihood Functions ; Macaca ; Male ; Papio ; Phylogeny ; RNA, Viral/blood ; Reverse Transcriptase Polymerase Chain Reaction ; Viral Load ; Viremia
مستخلص: Human pegivirus (HPgV)-formerly known as GB virus C and hepatitis G virus-is a poorly characterized RNA virus that infects about one-sixth of the global human population and is transmitted frequently in the blood supply. We create an animal model of HPgV infection by infecting macaque monkeys with a new simian pegivirus (SPgV) discovered in wild baboons. Using this model, we provide a high-resolution, longitudinal picture of SPgV viremia where the dose, route, and timing of infection are known. We detail the highly variable acute phase of SPgV infection, showing that the viral load trajectory early in infection is dependent on the infecting dose, whereas the chronic-phase viremic set point is not. We also show that SPgV has an extremely low propensity for accumulating sequence variation, with no consensus-level variants detected during the acute phase of infection and an average of only 1.5 variants generated per 100 infection-days. Finally, we show that SPgV RNA is highly concentrated in only two tissues: spleen and bone marrow, with bone marrow likely producing most of the virus detected in plasma. Together, these results reconcile several paradoxical observations from cross-sectional analyses of HPgV in humans and provide an animal model for studying pegivirus biology.
(Copyright © 2015, American Association for the Advancement of Science.)
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معلومات مُعتمدة: R01 TW009237 United States TW FIC NIH HHS; C06 RR020141 United States RR NCRR NIH HHS; C06 RR015459 United States RR NCRR NIH HHS; P51 RR000167 United States RR NCRR NIH HHS; RR15459-01 United States RR NCRR NIH HHS; T32 GM081061 United States GM NIGMS NIH HHS; RR020141-01 United States RR NCRR NIH HHS; R01 AI084787 United States AI NIAID NIH HHS; R01 AI077376 United States AI NIAID NIH HHS; P51RR000167 United States RR NCRR NIH HHS; T32 GM008692 United States GM NIGMS NIH HHS; TW009237 United States TW FIC NIH HHS; T32 AI078985 United States AI NIAID NIH HHS; T32 AI055397 United States AI NIAID NIH HHS; T32GM081061 United States GM NIGMS NIH HHS; P51 OD011106 United States OD NIH HHS; T32 AI55397 United States AI NIAID NIH HHS
المشرفين على المادة: 0 (RNA, Viral)
تواريخ الأحداث: Date Created: 20150918 Date Completed: 20160621 Latest Revision: 20181113
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC4605385
DOI: 10.1126/scitranslmed.aab3467
PMID: 26378244
قاعدة البيانات: MEDLINE
الوصف
تدمد:1946-6242
DOI:10.1126/scitranslmed.aab3467