دورية أكاديمية
Prolactin and growth hormone affect metaphase-II chromosomes in aging oocytes via cumulus cells using similar signaling pathways.
| العنوان: | Prolactin and growth hormone affect metaphase-II chromosomes in aging oocytes via cumulus cells using similar signaling pathways. |
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| المؤلفون: | Lebedeva IY; Center of Animal Biotechnology and Molecular Diagnostics, L.K. Ernst Institute of Animal Husbandry , Podolsk, Moscow Region, Russia., Singina GN; Center of Animal Biotechnology and Molecular Diagnostics, L.K. Ernst Institute of Animal Husbandry , Podolsk, Moscow Region, Russia., Lopukhov AV; Center of Animal Biotechnology and Molecular Diagnostics, L.K. Ernst Institute of Animal Husbandry , Podolsk, Moscow Region, Russia., Shedova EN; Center of Animal Biotechnology and Molecular Diagnostics, L.K. Ernst Institute of Animal Husbandry , Podolsk, Moscow Region, Russia., Zinovieva NA; Center of Animal Biotechnology and Molecular Diagnostics, L.K. Ernst Institute of Animal Husbandry , Podolsk, Moscow Region, Russia. |
| المصدر: | Frontiers in genetics [Front Genet] 2015 Aug 27; Vol. 6, pp. 274. Date of Electronic Publication: 2015 Aug 27 (Print Publication: 2015). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Frontiers Research Foundation Country of Publication: Switzerland NLM ID: 101560621 Publication Model: eCollection Cited Medium: Print ISSN: 1664-8021 (Print) Linking ISSN: 16648021 NLM ISO Abbreviation: Front Genet Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Lausanne : Frontiers Research Foundation. |
| مستخلص: | General senescence of the adult organism is closely connected with reproductive one. Meanwhile, the age-related reduction in the female fertility is primarily associated with a decline in the gamete quality. Molecular and cellular changes in oocytes of old mammalian females are very similar to those occurring during aging of matured ova of their young counterparts, suggesting similarities in underlying mechanisms. The aim of the present work was to study actions of two related pituitary hormones, prolactin (PRL) and growth hormone (GH), on age-associated modifications of metaphase-II (M-II) chromosomes in bovine oocytes using a model of the prolonged culture. We analyzed: (1) effects of PRL and GH on abnormal changes in the chromosome morphology in aging matured oocytes and the role of cumulus cells in these effects and (2) signaling pathways involved in the hormone actions. During the prolonged culture of oocytes, a gradual rise in the frequency of destructive modifications of M-II chromosomes was revealed. In the case of cumulus-enclosed oocytes (CEOs), PRL and GH exerted dose-dependent biphasic effects on the frequency of these modifications. Both PRL (50 ng/ml) and GH (10 ng/ml) decelerated the abnormal chromosome changes in CEOs, but did not affect the chromosome configuration in denuded oocytes. Concurrently, the presence of PRL and GH receptors in cumulus cells surrounding matured oocytes was demonstrated. Attenuating effects of both hormones on the chromosome modifications in aging CEOs were abolished by PP2 (an inhibitor of Src-family tyrosine kinases), triciribine (an inhibitor of Akt kinase), and calphostin C (a protein kinase C inhibitor). Our findings indicate that PRL and GH can exert the similar decelerating action on age-associated alterations in the M-II chromosome morphology in bovine ova, which is mediated by cumulus cells and may be related to activation of Src-family tyrosine kinases as well as Akt- and protein kinase C-dependent signal pathways. |
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| فهرسة مساهمة: | Keywords: chromosome modifications; cumulus cells; growth hormone; oocyte aging; prolactin; receptors; signaling pathways |
| تواريخ الأحداث: | Date Created: 20150918 Date Completed: 20150918 Latest Revision: 20201001 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC4550791 |
| DOI: | 10.3389/fgene.2015.00274 |
| PMID: | 26379702 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1664-8021 |
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| DOI: | 10.3389/fgene.2015.00274 |