دورية أكاديمية
Computational pharmacokinetics and in vitro-in vivo correlation of anti-diabetic synergistic phyto-composite blend.
| العنوان: | Computational pharmacokinetics and in vitro-in vivo correlation of anti-diabetic synergistic phyto-composite blend. |
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| المؤلفون: | De B; Baishakhi De, Koushik Bhandari, Nishant Chakravorty, Ranjan Mukherjee, Biswajoy Ghosh, Analava Mitra, School of Medical Science and Technology, IIT Kharagpur 721302, India., Bhandari K; Baishakhi De, Koushik Bhandari, Nishant Chakravorty, Ranjan Mukherjee, Biswajoy Ghosh, Analava Mitra, School of Medical Science and Technology, IIT Kharagpur 721302, India., Chakravorty N; Baishakhi De, Koushik Bhandari, Nishant Chakravorty, Ranjan Mukherjee, Biswajoy Ghosh, Analava Mitra, School of Medical Science and Technology, IIT Kharagpur 721302, India., Mukherjee R; Baishakhi De, Koushik Bhandari, Nishant Chakravorty, Ranjan Mukherjee, Biswajoy Ghosh, Analava Mitra, School of Medical Science and Technology, IIT Kharagpur 721302, India., Gundamaraju R; Baishakhi De, Koushik Bhandari, Nishant Chakravorty, Ranjan Mukherjee, Biswajoy Ghosh, Analava Mitra, School of Medical Science and Technology, IIT Kharagpur 721302, India., Singla RK; Baishakhi De, Koushik Bhandari, Nishant Chakravorty, Ranjan Mukherjee, Biswajoy Ghosh, Analava Mitra, School of Medical Science and Technology, IIT Kharagpur 721302, India., Katakam P; Baishakhi De, Koushik Bhandari, Nishant Chakravorty, Ranjan Mukherjee, Biswajoy Ghosh, Analava Mitra, School of Medical Science and Technology, IIT Kharagpur 721302, India., Adiki SK; Baishakhi De, Koushik Bhandari, Nishant Chakravorty, Ranjan Mukherjee, Biswajoy Ghosh, Analava Mitra, School of Medical Science and Technology, IIT Kharagpur 721302, India., Ghosh B; Baishakhi De, Koushik Bhandari, Nishant Chakravorty, Ranjan Mukherjee, Biswajoy Ghosh, Analava Mitra, School of Medical Science and Technology, IIT Kharagpur 721302, India., Mitra A; Baishakhi De, Koushik Bhandari, Nishant Chakravorty, Ranjan Mukherjee, Biswajoy Ghosh, Analava Mitra, School of Medical Science and Technology, IIT Kharagpur 721302, India. |
| المصدر: | World journal of diabetes [World J Diabetes] 2015 Sep 10; Vol. 6 (11), pp. 1179-85. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Baishideng Publishing Group Country of Publication: United States NLM ID: 101547524 Publication Model: Print Cited Medium: Print ISSN: 1948-9358 (Print) Linking ISSN: 19489358 NLM ISO Abbreviation: World J Diabetes Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Publication: 2014-: Pleasanton, CA : Baishideng Publishing Group Original Publication: Beijing, China : Beijing Baishideng BioMed Scientifc Company |
| مستخلص: | Despite tremendous strides in modern medicine stringent control over insulin resistance or restoration of normoglycemia has not yet been achieved. With the growth of molecular biology, omics technologies, docking studies, and in silico pharmacology, modulators of enzymes and receptors affecting the molecular pathogenesis of the disease are being considered as the latest targets for anti-diabetic therapy. Therapeutic molecular targets are now being developed basing on the up or down regulation of different signaling pathways affecting the disease. Phytosynergistic anti-diabetic therapy is in vogue both with classical and non-classical medicinal systems. However its chemo-profiling, structural and pharmacokinetic validation awaits providing recognition to such formulations for international acceptance. Translational health research with its focus on benchside product development and its sequential transition to patient bedside puts the pharma RDs to a challenge to develop bio-waiver protocols. Pharmacokinetic simulation models and establishment of in vitro-in vivo correlation can help to replace in vivo bioavailability studies and provide means of quality control for scale up and post approval modification. This review attempts to bring different shades highlighting phyto-synergy, molecular targeting of antidiabetic agents via different signaling pathways and bio-waiver studies under a single umbrella. |
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| فهرسة مساهمة: | Keywords: Anti-diabetic; Bio-waiver; In silico pharmacology; Phytosynergistic; Signaling pathways; Simulation models; Translational health research |
| تواريخ الأحداث: | Date Created: 20150918 Date Completed: 20150918 Latest Revision: 20240323 |
| رمز التحديث: | 20240323 |
| مُعرف محوري في PubMed: | PMC4564813 |
| DOI: | 10.4239/wjd.v6.i11.1179 |
| PMID: | 26380061 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1948-9358 |
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| DOI: | 10.4239/wjd.v6.i11.1179 |