دورية أكاديمية
Glucose-Dependent Insulinotropic Polypeptide Stimulates Osteopontin Expression in the Vasculature via Endothelin-1 and CREB.
| العنوان: | Glucose-Dependent Insulinotropic Polypeptide Stimulates Osteopontin Expression in the Vasculature via Endothelin-1 and CREB. |
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| المؤلفون: | Berglund LM; Department of Clinical Sciences, Lund University, Malmö, Sweden., Lyssenko V; Department of Clinical Sciences, Lund University, Malmö, Sweden Steno Diabetes Center A/S, Gentofte, Denmark., Ladenvall C; Department of Clinical Sciences, Lund University, Malmö, Sweden., Kotova O; Department of Clinical Sciences, Lund University, Malmö, Sweden., Edsfeldt A; Department of Clinical Sciences, Lund University, Malmö, Sweden., Pilgaard K; Steno Diabetes Center A/S, Gentofte, Denmark., Alkayyali S; Department of Clinical Sciences, Lund University, Malmö, Sweden., Brøns C; Steno Diabetes Center A/S, Gentofte, Denmark., Forsblom C; Folkhälsan Institute of Genetics, Folkhälsan Research Center, Biomedicum Helsinki, Helsinki, Finland Division of Nephrology, Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland., Jonsson A; Department of Clinical Sciences, Lund University, Malmö, Sweden., Zetterqvist AV; Department of Clinical Sciences, Lund University, Malmö, Sweden., Nitulescu M; Department of Clinical Sciences, Lund University, Malmö, Sweden., McDavitt CR; Department of Clinical Sciences, Lund University, Malmö, Sweden., Dunér P; Department of Clinical Sciences, Lund University, Malmö, Sweden., Stancáková A; Department of Medicine, University of Eastern Finland, Kuopio University Hospital, Kuopio, Finland., Kuusisto J; Department of Medicine, University of Eastern Finland, Kuopio University Hospital, Kuopio, Finland., Ahlqvist E; Department of Clinical Sciences, Lund University, Malmö, Sweden., Lajer M; Steno Diabetes Center A/S, Gentofte, Denmark., Tarnow L; Steno Diabetes Center A/S, Gentofte, Denmark HEALTH University of Aarhus, Aarhus, Denmark., Madsbad S; Department of Endocrinology, Hvidovre Hospital, University of Copenhagen, Copenhagen, Denmark., Rossing P; Steno Diabetes Center A/S, Gentofte, Denmark HEALTH University of Aarhus, Aarhus, Denmark NNF Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark., Kieffer TJ; Department of Cellular and Physiological Sciences and Surgery, University of British Columbia, Vancouver, BC, Canada., Melander O; Department of Clinical Sciences, Lund University, Malmö, Sweden., Orho-Melander M; Department of Clinical Sciences, Lund University, Malmö, Sweden., Nilsson P; Department of Clinical Sciences, Lund University, Malmö, Sweden., Groop PH; Folkhälsan Institute of Genetics, Folkhälsan Research Center, Biomedicum Helsinki, Helsinki, Finland Division of Nephrology, Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland., Vaag A; Department of Clinical Sciences, Lund University, Malmö, Sweden Steno Diabetes Center A/S, Gentofte, Denmark Department of Endocrinology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark., Lindblad B; Department of Clinical Sciences, Lund University, Malmö, Sweden., Gottsäter A; Department of Clinical Sciences, Lund University, Malmö, Sweden., Laakso M; Department of Medicine, University of Eastern Finland, Kuopio University Hospital, Kuopio, Finland., Goncalves I; Department of Cardiology, Skåne University Hospital, Malmö, Sweden., Groop L; Department of Clinical Sciences, Lund University, Malmö, Sweden., Gomez MF; Department of Clinical Sciences, Lund University, Malmö, Sweden maria.gomez@med.lu.se. |
| المصدر: | Diabetes [Diabetes] 2016 Jan; Vol. 65 (1), pp. 239-54. Date of Electronic Publication: 2015 Sep 22. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Diabetes Association Country of Publication: United States NLM ID: 0372763 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1939-327X (Electronic) Linking ISSN: 00121797 NLM ISO Abbreviation: Diabetes Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Alexandria, VA : American Diabetes Association Original Publication: [New York, American Diabetes Association] |
| مواضيع طبية MeSH: | Cyclic AMP Response Element-Binding Protein/*metabolism , Endothelial Cells/*metabolism , Endothelin-1/*genetics , Gastric Inhibitory Polypeptide/*metabolism , Myocytes, Smooth Muscle/*metabolism , Osteopontin/*genetics , RNA, Messenger/*metabolism , Receptors, Gastrointestinal Hormone/*genetics, Aged ; Aged, 80 and over ; Animals ; Aorta/cytology ; Blotting, Western ; Cardiovascular Diseases/genetics ; Carotid Arteries/cytology ; Case-Control Studies ; Coronary Vessels/cytology ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/genetics ; Diabetes Mellitus, Type 2/metabolism ; Endothelin-1/metabolism ; Enzyme-Linked Immunosorbent Assay ; Female ; Fluorescent Antibody Technique ; Humans ; Immunohistochemistry ; Male ; Mice ; Mice, Knockout ; Microscopy, Confocal ; Microvessels/cytology ; Middle Aged ; Osteopontin/metabolism ; Peripheral Arterial Disease/metabolism ; Plaque, Atherosclerotic/metabolism ; Polymorphism, Single Nucleotide ; Rats ; Rats, Inbred WKY ; Real-Time Polymerase Chain Reaction ; Stroke/complications ; Stroke/genetics ; Stroke/metabolism ; Sus scrofa ; Swine |
| مستخلص: | Glucose-dependent insulinotropic polypeptide (GIP) is an incretin hormone with extrapancreatic effects beyond glycemic control. Here we demonstrate unexpected effects of GIP signaling in the vasculature. GIP induces the expression of the proatherogenic cytokine osteopontin (OPN) in mouse arteries via local release of endothelin-1 and activation of CREB. Infusion of GIP increases plasma OPN concentrations in healthy individuals. Plasma endothelin-1 and OPN concentrations are positively correlated in patients with critical limb ischemia. Fasting GIP concentrations are higher in individuals with a history of cardiovascular disease (myocardial infarction, stroke) when compared with control subjects. GIP receptor (GIPR) and OPN mRNA levels are higher in carotid endarterectomies from patients with symptoms (stroke, transient ischemic attacks, amaurosis fugax) than in asymptomatic patients, and expression associates with parameters that are characteristic of unstable and inflammatory plaques (increased lipid accumulation, macrophage infiltration, and reduced smooth muscle cell content). While GIPR expression is predominantly endothelial in healthy arteries from humans, mice, rats, and pigs, remarkable upregulation is observed in endothelial and smooth muscle cells upon culture conditions, yielding a "vascular disease-like" phenotype. Moreover, the common variant rs10423928 in the GIPR gene is associated with increased risk of stroke in patients with type 2 diabetes. (© 2016 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered.) |
| المشرفين على المادة: | 0 (Cyclic AMP Response Element-Binding Protein) 0 (Endothelin-1) 0 (RNA, Messenger) 0 (Receptors, Gastrointestinal Hormone) 106441-73-0 (Osteopontin) 59392-49-3 (Gastric Inhibitory Polypeptide) D6H00MV7K8 (gastric inhibitory polypeptide receptor) |
| تواريخ الأحداث: | Date Created: 20150924 Date Completed: 20160428 Latest Revision: 20181024 |
| رمز التحديث: | 20231215 |
| DOI: | 10.2337/db15-0122 |
| PMID: | 26395740 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1939-327X |
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| DOI: | 10.2337/db15-0122 |