دورية أكاديمية
أعرض في EDS

Exercise Therapy for Parkinson's Disease: Pedaling Rate Is Related to Changes in Motor Connectivity.

التفاصيل البيبلوغرافية
العنوان: Exercise Therapy for Parkinson's Disease: Pedaling Rate Is Related to Changes in Motor Connectivity.
المؤلفون: Shah C; 1 Department of Radiology, Hospital of the University of Pennsylvania , Philadelphia, Pennsylvania., Beall EB; 2 Imaging Institute , Cleveland Clinic, Cleveland, Ohio., Frankemolle AM; 3 Department of Biomedical Engineering, Case Western Reserve University , Cleveland, Ohio., Penko A; 4 Center for Neurological Restoration , Cleveland Clinic, Cleveland, Ohio., Phillips MD; 2 Imaging Institute , Cleveland Clinic, Cleveland, Ohio., Lowe MJ; 2 Imaging Institute , Cleveland Clinic, Cleveland, Ohio., Alberts JL; 3 Department of Biomedical Engineering, Case Western Reserve University , Cleveland, Ohio.; 4 Center for Neurological Restoration , Cleveland Clinic, Cleveland, Ohio.; 5 Cleveland FES Center, L. Stokes Cleveland VA Medical Center , Cleveland, Ohio.
المصدر: Brain connectivity [Brain Connect] 2016 Feb; Vol. 6 (1), pp. 25-36. Date of Electronic Publication: 2015 Oct 20.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
اللغة: English
بيانات الدورية: Publisher: Mary Ann Liebert, Inc Country of Publication: United States NLM ID: 101550313 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2158-0022 (Electronic) Linking ISSN: 21580014 NLM ISO Abbreviation: Brain Connect Subsets: MEDLINE
أسماء مطبوعة: Original Publication: New Rochelle, NY : Mary Ann Liebert, Inc.
مواضيع طبية MeSH: Brain Mapping* , Exercise Therapy*/methods, Motor Cortex/*physiopathology , Nerve Net/*physiopathology , Parkinson Disease/*therapy, Adult ; Aged ; Female ; Humans ; Image Processing, Computer-Assisted ; Magnetic Resonance Imaging/methods ; Male ; Middle Aged ; Nerve Net/physiology ; Neural Pathways/physiopathology ; Parkinson Disease/physiopathology ; Thalamus/physiopathology
مستخلص: Forced-rate lower-extremity exercise has recently emerged as a potential safe and low-cost therapy for Parkinson's disease (PD). The efficacy is believed to be dependent on pedaling rate, with rates above the subjects' voluntary exercise rates being most beneficial. In this study, we use functional connectivity magnetic resonance imaging (MRI) to further elucidate the mechanism underlying this effect. Twenty-seven PD patients were randomized to complete 8 weeks of forced-rate exercise (FE) or voluntary-rate exercise (VE). Exercise was delivered using a specialized stationary bicycle, which can augment patients' voluntary exercise rates. The FE group received assistance from the cycle. Imaging was conducted at baseline, end of therapy, and after 4 weeks of follow-up. Functional connectivity (FC) was determined via seed-based correlation analysis, using activation-based seeds in the primary motor cortex (M1). The change in FC after exercise was compared using linear correlation with pedaling rate. Results of the correlation analysis showed a strong positive correlation between pedaling rate and change in FC from the most affected M1 to the ipsilateral thalamus. This effect persisted after 4 weeks of follow-up. These results indicate that a plausible mechanism for the therapeutic efficacy of high-rate exercise in PD is that it improves thalamo-cortical connectivity.
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فهرسة مساهمة: Keywords: Parkinson's disease; exercise; functional MRI; functional connectivity
تواريخ الأحداث: Date Created: 20150929 Date Completed: 20161025 Latest Revision: 20220408
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC4744893
DOI: 10.1089/brain.2014.0328
PMID: 26414696
قاعدة البيانات: MEDLINE
الوصف
تدمد:2158-0022
DOI:10.1089/brain.2014.0328