دورية أكاديمية
Cathelicidin as a link between sarcoidosis and tuberculosis.
| العنوان: | Cathelicidin as a link between sarcoidosis and tuberculosis. |
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| المؤلفون: | Korucu E; Yedikule Chest Diseases and Surgery Education and Research Hospital, Istanbul. korucuercan@hotmail.com., Pur Ozyigit L, Ortakoylu MG, Bahadir A, Akalin ES, Kara A, Uzun H, Onal B, Caglar E |
| المصدر: | Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG [Sarcoidosis Vasc Diffuse Lung Dis] 2015 Sep 14; Vol. 32 (3), pp. 222-7. Date of Electronic Publication: 2015 Sep 14. |
| نوع المنشور: | Comparative Study; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Mattioli 1885 Country of Publication: Italy NLM ID: 9610928 Publication Model: Electronic Cited Medium: Internet ISSN: 2532-179X (Electronic) Linking ISSN: 11240490 NLM ISO Abbreviation: Sarcoidosis Vasc Diffuse Lung Dis Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2000- : Parma, Italy : Mattioli 1885 Original Publication: Cormano, Milan, Italy : PCA Pub., c1996- |
| مواضيع طبية MeSH: | Antimicrobial Cationic Peptides/*blood , Sarcoidosis, Pulmonary/*blood , Tuberculosis, Pulmonary/*blood, Adolescent ; Adult ; Aged ; Biomarkers/blood ; Case-Control Studies ; Cross-Sectional Studies ; Diagnosis, Differential ; Down-Regulation ; Female ; Humans ; Male ; Middle Aged ; Predictive Value of Tests ; Prospective Studies ; Sarcoidosis, Pulmonary/diagnosis ; Tuberculosis, Pulmonary/diagnosis ; Vitamin D/analogs & derivatives ; Vitamin D/blood ; Vitamin D Deficiency/blood ; Vitamin D Deficiency/diagnosis ; Young Adult ; Cathelicidins |
| مستخلص: | Setting: Sarcoidosis and tuberculosis share notable clinical, radiological, histological, and immunological similarities. The importance of vitamin D has long been investigated in these two granulomatous lung diseases. Cathelicidin is an antimicrobial peptide of the innate immune system, directly induced by vitD3. Objective: To evaluate the role of cathelicidin in sarcoidosis and tuberculosis development. Design: The study included 30 consecutive patients with active lung tuberculosis, 30 patients with sarcoidosis, and 20 healthy controls. 25-hydroxyvitamin D [25(OH)D] and cathelicidin levels were measured in blood samples. Results: Vitamin D levels were significantly higher (p<0.001) in tuberculosis patients (22.5 ± 9.96 ng/ml) than in sarcoidosis patients (11.75 ± 8.92 ng/ml). Severe vitamin D deficiency was as frequent as 47% in sarcoidosis patients compared to only 3% in tuberculosis patients. Cathelicidin levels were significantly higher in the control group (120.37 ± 41.03 pg/ml) than in sarcoidosis (67.68 ± 38.03 pg/ml) and tuberculosis (68.74 ± 39.44 pg/ml) patients (p<0.001). However, no significant difference in cathelicidin levels was observed between tuberculosis and sarcoidosis patients (p=0.966). The optimum cathelicidin cut-off value to distinguish sarcoidosis patients from healthy controls was 107.14 pg/ml (sensitivity 81.5%, specificity 71.2%). Conclusion: Cathelicidin appears to play different roles in the development of granulomatous lung disease. |
| المشرفين على المادة: | 0 (Antimicrobial Cationic Peptides) 0 (Biomarkers) 1406-16-2 (Vitamin D) A288AR3C9H (25-hydroxyvitamin D) 0 (Cathelicidins) |
| تواريخ الأحداث: | Date Created: 20151001 Date Completed: 20160714 Latest Revision: 20221207 |
| رمز التحديث: | 20240628 |
| PMID: | 26422567 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2532-179X |
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