دورية أكاديمية
أعرض في EDS

Arrhythmogenic Risk Assessment Following Four-Week Pretreatment With Nicotine and Black Tea in Rat.

التفاصيل البيبلوغرافية
العنوان: Arrhythmogenic Risk Assessment Following Four-Week Pretreatment With Nicotine and Black Tea in Rat.
المؤلفون: Joukar S; Physiology Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, IR Iran ; Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, IR Iran ; Department of Physiology and Pharmacology, Kerman University of Medical Sciences, Kerman, IR Iran., Sheibani V; Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, IR Iran ; Department of Physiology and Pharmacology, Kerman University of Medical Sciences, Kerman, IR Iran., Koushesh F; School of Allied Medical Sciences, Bushehr University of Medical Sciences, Bushehr, IR Iran., Ghasemipoor Afshar E; Physiology Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, IR Iran ; Department of Physiology and Pharmacology, Kerman University of Medical Sciences, Kerman, IR Iran., Ghorbani Shahrbabaki S; Physiology Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, IR Iran.
المصدر: Research in cardiovascular medicine [Res Cardiovasc Med] 2015 Aug 01; Vol. 4 (3), pp. e27088. Date of Electronic Publication: 2015 Aug 01 (Print Publication: 2015).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Wolters Kluwer - Medknow Country of Publication: India NLM ID: 101608315 Publication Model: eCollection Cited Medium: Print ISSN: 2251-9572 (Print) Linking ISSN: 22519572 NLM ISO Abbreviation: Res Cardiovasc Med Subsets: PubMed not MEDLINE
أسماء مطبوعة: Publication: [Mumbai] : Wolters Kluwer - Medknow
Original Publication: Tehran IR, Iran : KOWSAR, [2012]-
مستخلص: Background: There is the controversy concerning the main component of tobacco, which is responsible for its arrhythmogenesis. In addition, there is the lack of adequate information about the influence of combination of black tea and nicotine on heart rhythm.
Objectives: This study aimed to examine whether pretreatment with black tea and nicotine could modulate the susceptibility to lethal ventricular arrhythmias.
Materials and Methods: Animals were randomized to control, black tea, nicotine, and black tea plus nicotine groups. Test groups were treated with black tea brewed (orally) and nicotine (2 mg/kg, subcutaneous), alone and in combination for four weeks. On day 29, aconitine was infused intravenously for induction of cardiac arrhythmia.
Results: In comparison with the control group, each of tea and nicotine significantly decreased the duration of the ventricular tachycardia (VT) plus ventricular fibrillation (VF) and the score of arrhythmia severity (P < 0.05 and P < 0.01, respectively,). The latency for the first VT event was significantly longer in the all test groups, but VF latency was significant only in tea and nicotine groups compared with control group (P < 0.05 and P < 0.01, respectively).Threshold dose of aconitine for inducing VT and VF increased in all test groups, but only VT showed a significant difference in comparison to the control group (P < 0.001).
Conclusions: The findings suggest that sub-chronic consumption of nicotine or black tea alone with appropriate doses could potentially be antiarrhythmic and its combination regimen does not increase the risk of fatal ventricular arrhythmias during four-week consumption period in rats.
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فهرسة مساهمة: Keywords: Ventricular Arrhythmia, Black Tea, Nicotine
تواريخ الأحداث: Date Created: 20151006 Date Completed: 20151005 Latest Revision: 20200930
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC4588709
DOI: 10.5812/cardiovascmed.27088v2
PMID: 26436072
قاعدة البيانات: MEDLINE
الوصف
تدمد:2251-9572
DOI:10.5812/cardiovascmed.27088v2