دورية أكاديمية
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DNA methylome analysis in Burkitt and follicular lymphomas identifies differentially methylated regions linked to somatic mutation and transcriptional control.

التفاصيل البيبلوغرافية
العنوان: DNA methylome analysis in Burkitt and follicular lymphomas identifies differentially methylated regions linked to somatic mutation and transcriptional control.
المؤلفون: Kretzmer H; Transcriptome Bioinformatics, LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany.; Interdisciplinary Center for Bioinformatics, University of Leipzig, Leipzig, Germany.; Bioinformatics Group, Department of Computer Science, University of Leipzig, Leipzig, Germany.; German ICGC MMML-Seq-project., Bernhart SH; Transcriptome Bioinformatics, LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany.; Interdisciplinary Center for Bioinformatics, University of Leipzig, Leipzig, Germany.; Bioinformatics Group, Department of Computer Science, University of Leipzig, Leipzig, Germany.; German ICGC MMML-Seq-project., Wang W; German Cancer Research Center (DKFZ), Division Molecular Genetics, Heidelberg, Germany., Haake A; German ICGC MMML-Seq-project.; Institute of Human Genetics, Christian-Albrechts-University, Kiel, Germany., Weniger MA; German ICGC MMML-Seq-project.; Institute of Cell Biology (Cancer Research), University of Duisburg-Essen, Essen, Germany., Bergmann AK; Institute of Human Genetics, Christian-Albrechts-University, Kiel, Germany.; Department of Pediatrics, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.; BLUEPRINT project., Betts MJ; Cell Networks, Bioquant, University of Heidelberg, Heidelberg, Germany., Carrillo-de-Santa-Pau E; BLUEPRINT project.; Structural Biology and BioComputing Programme, Spanish National Cancer Research Center (CNIO), Madrid, Spain., Doose G; Transcriptome Bioinformatics, LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany.; Interdisciplinary Center for Bioinformatics, University of Leipzig, Leipzig, Germany.; Bioinformatics Group, Department of Computer Science, University of Leipzig, Leipzig, Germany.; German ICGC MMML-Seq-project., Gutwein J; Institute of Human Genetics, Christian-Albrechts-University, Kiel, Germany., Richter J; German ICGC MMML-Seq-project.; Institute of Human Genetics, Christian-Albrechts-University, Kiel, Germany., Hovestadt V; German Cancer Research Center (DKFZ), Division Molecular Genetics, Heidelberg, Germany., Huang B; Deutsches Krebsforschungszentrum Heidelberg (DKFZ), Division Theoretical Bioinformatics, Heidelberg, Germany., Rico D; BLUEPRINT project.; Structural Biology and BioComputing Programme, Spanish National Cancer Research Center (CNIO), Madrid, Spain., Jühling F; Transcriptome Bioinformatics, LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany.; Interdisciplinary Center for Bioinformatics, University of Leipzig, Leipzig, Germany.; Bioinformatics Group, Department of Computer Science, University of Leipzig, Leipzig, Germany., Kolarova J; Institute of Human Genetics, Christian-Albrechts-University, Kiel, Germany., Lu Q; Cell Networks, Bioquant, University of Heidelberg, Heidelberg, Germany., Otto C; Transcriptome Bioinformatics, LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany.; Interdisciplinary Center for Bioinformatics, University of Leipzig, Leipzig, Germany.; Bioinformatics Group, Department of Computer Science, University of Leipzig, Leipzig, Germany., Wagener R; German ICGC MMML-Seq-project.; Institute of Human Genetics, Christian-Albrechts-University, Kiel, Germany., Arnolds J; Department of Otorhinolaryngology, University of Duisburg-Essen, Essen, Germany., Burkhardt B; German ICGC MMML-Seq-project.; University Hospital Muenster - Pediatric Hematology and Oncology, Münster Germany., Claviez A; German ICGC MMML-Seq-project.; Department of Pediatrics, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany., Drexler HG; Leibniz-Institut DSMZ, German Collection of Microorganisms and Cell Cultures, Braunschweig, Germany., Eberth S; German ICGC MMML-Seq-project.; Leibniz-Institut DSMZ, German Collection of Microorganisms and Cell Cultures, Braunschweig, Germany.; Department of Hematology and Oncology, Georg-Augusts-University of Göttingen, Göttingen, Germany., Eils R; German ICGC MMML-Seq-project.; Deutsches Krebsforschungszentrum Heidelberg (DKFZ), Division Theoretical Bioinformatics, Heidelberg, Germany.; Institute of Pharmacy and Molecular Biotechnology, Bioquant, University of Heidelberg, Heidelberg, Germany., Flicek P; BLUEPRINT project.; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, UK., Haas S; German ICGC MMML-Seq-project.; Friedrich-Ebert Hospital Neumuenster, Clinics for Haematology, Oncology and Nephrology, Neumünster, Germany., Humme M; German ICGC MMML-Seq-project.; Institute of Pathology, Charité - University Medicine Berlin, Berlin, Germany., Karsch D; German ICGC MMML-Seq-project.; Department of Internal Medicine II: Hematology and Oncology, University Medical Centre, Campus Kiel, Kiel, Germany., Kerstens HHD; BLUEPRINT project.; Radboud University, Department of Molecular Biology, Faculty of Science, Nijmegen, Netherlands., Klapper W; German ICGC MMML-Seq-project.; Hematopathology Section, Christian-Albrechts-University, Kiel, Germany., Kreuz M; German ICGC MMML-Seq-project.; BLUEPRINT project.; Institute for Medical Informatics Statistics and Epidemiology, University of Leipzig, Leipzig, Germany., Lawerenz C; German ICGC MMML-Seq-project.; Deutsches Krebsforschungszentrum Heidelberg (DKFZ), Division Theoretical Bioinformatics, Heidelberg, Germany., Lenzek D; German ICGC MMML-Seq-project.; Institute of Pathology, Charité - University Medicine Berlin, Berlin, Germany., Loeffler M; German ICGC MMML-Seq-project.; BLUEPRINT project.; Institute for Medical Informatics Statistics and Epidemiology, University of Leipzig, Leipzig, Germany., López C; German ICGC MMML-Seq-project.; Institute of Human Genetics, Christian-Albrechts-University, Kiel, Germany., MacLeod RAF; Leibniz-Institut DSMZ, German Collection of Microorganisms and Cell Cultures, Braunschweig, Germany., Martens JHA; BLUEPRINT project.; Radboud University, Department of Molecular Biology, Faculty of Science, Nijmegen, Netherlands., Kulis M; BLUEPRINT project.; Radboud University, Department of Molecular Biology, Faculty of Science, Nijmegen, Netherlands., Martín-Subero JI; BLUEPRINT project.; Departamento de Anatomía Patológica, Farmacología y Microbiología, Universitat de Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain., Möller P; German ICGC MMML-Seq-project.; Institute of Pathology, Medical Faculty of the Ulm University, Ulm, Germany., Nage I; German ICGC MMML-Seq-project.; Institute of Human Genetics, Christian-Albrechts-University, Kiel, Germany., Picelli S; German Cancer Research Center (DKFZ), Division Molecular Genetics, Heidelberg, Germany., Vater I; German ICGC MMML-Seq-project.; Institute of Human Genetics, Christian-Albrechts-University, Kiel, Germany., Rohde M; German ICGC MMML-Seq-project.; University Hospital Giessen, Pediatric Hematology and Oncology, Giessen, Germany., Rosenstiel P; German ICGC MMML-Seq-project.; Institute of Clinical Molecular Biology, Christian-Albrechts-University, Kiel, Germany., Rosolowski M; German ICGC MMML-Seq-project.; Institute for Medical Informatics Statistics and Epidemiology, University of Leipzig, Leipzig, Germany., Russell RB; Cell Networks, Bioquant, University of Heidelberg, Heidelberg, Germany., Schilhabel M; German ICGC MMML-Seq-project.; Institute of Clinical Molecular Biology, Christian-Albrechts-University, Kiel, Germany., Schlesner M; German ICGC MMML-Seq-project.; Deutsches Krebsforschungszentrum Heidelberg (DKFZ), Division Theoretical Bioinformatics, Heidelberg, Germany., Stadler PF; Transcriptome Bioinformatics, LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany.; Interdisciplinary Center for Bioinformatics, University of Leipzig, Leipzig, Germany.; Bioinformatics Group, Department of Computer Science, University of Leipzig, Leipzig, Germany.; German ICGC MMML-Seq-project.; RNomics Group, Fraunhofer Institute for Cell Therapy and Immunology IZI, Leipzig, Germany.; Santa Fe Institute, Santa Fe, New Mexico, United States of America.; Max-Planck-Institute for Mathematics in Sciences, Leipzig, Germany., Szczepanowski M; German ICGC MMML-Seq-project., Trümper L; German ICGC MMML-Seq-project.; Department of Hematology and Oncology, Georg-Augusts-University of Göttingen, Göttingen, Germany., Stunnenberg HG; BLUEPRINT project.; Radboud University, Department of Molecular Biology, Faculty of Science, Nijmegen, Netherlands., Küppers R; German ICGC MMML-Seq-project.; Institute of Cell Biology (Cancer Research), University of Duisburg-Essen, Essen, Germany.; BLUEPRINT project., Ammerpohl O; German ICGC MMML-Seq-project.; Institute of Human Genetics, Christian-Albrechts-University, Kiel, Germany., Lichter P; German ICGC MMML-Seq-project.; German Cancer Research Center (DKFZ), Division Molecular Genetics, Heidelberg, Germany., Siebert R; German ICGC MMML-Seq-project.; Institute of Human Genetics, Christian-Albrechts-University, Kiel, Germany.; BLUEPRINT project., Hoffmann S; Transcriptome Bioinformatics, LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany.; Interdisciplinary Center for Bioinformatics, University of Leipzig, Leipzig, Germany.; Bioinformatics Group, Department of Computer Science, University of Leipzig, Leipzig, Germany.; German ICGC MMML-Seq-project.; BLUEPRINT project., Radlwimmer B; German ICGC MMML-Seq-project.; German Cancer Research Center (DKFZ), Division Molecular Genetics, Heidelberg, Germany.
المصدر: Nature genetics [Nat Genet] 2015 Nov; Vol. 47 (11), pp. 1316-1325. Date of Electronic Publication: 2015 Oct 05.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Nature Pub. Co Country of Publication: United States NLM ID: 9216904 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1718 (Electronic) Linking ISSN: 10614036 NLM ISO Abbreviation: Nat Genet Subsets: MEDLINE
أسماء مطبوعة: Original Publication: New York, NY : Nature Pub. Co., c1992-
مواضيع طبية MeSH: DNA Methylation* , Mutation*, Burkitt Lymphoma/*genetics , Lymphoma, Follicular/*genetics , Transcriptome/*genetics, Adolescent ; Adult ; Aged ; B-Lymphocytes/metabolism ; Cell Line, Tumor ; Child ; Child, Preschool ; Female ; Genome, Human/genetics ; Germinal Center/metabolism ; High-Throughput Nucleotide Sequencing/methods ; Humans ; Male ; Middle Aged ; Oncogene Proteins, Fusion/genetics ; Proto-Oncogene Proteins c-bcl-2/genetics ; Proto-Oncogene Proteins c-myc/genetics ; Signal Transduction/genetics ; Translocation, Genetic ; Young Adult
مستخلص: Although Burkitt lymphomas and follicular lymphomas both have features of germinal center B cells, they are biologically and clinically quite distinct. Here we performed whole-genome bisulfite, genome and transcriptome sequencing in 13 IG-MYC translocation-positive Burkitt lymphoma, nine BCL2 translocation-positive follicular lymphoma and four normal germinal center B cell samples. Comparison of Burkitt and follicular lymphoma samples showed differential methylation of intragenic regions that strongly correlated with expression of associated genes, for example, genes active in germinal center dark-zone and light-zone B cells. Integrative pathway analyses of regions differentially methylated in Burkitt and follicular lymphomas implicated DNA methylation as cooperating with somatic mutation of sphingosine phosphate signaling, as well as the TCF3-ID3 and SWI/SNF complexes, in a large fraction of Burkitt lymphomas. Taken together, our results demonstrate a tight connection between somatic mutation, DNA methylation and transcriptional control in key B cell pathways deregulated differentially in Burkitt lymphoma and other germinal center B cell lymphomas.
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معلومات مُعتمدة: 095908 United Kingdom Wellcome Trust
المشرفين على المادة: 0 (MYC protein, human)
0 (Oncogene Proteins, Fusion)
0 (Proto-Oncogene Proteins c-bcl-2)
0 (Proto-Oncogene Proteins c-myc)
تواريخ الأحداث: Date Created: 20151006 Date Completed: 20160307 Latest Revision: 20231112
رمز التحديث: 20231112
مُعرف محوري في PubMed: PMC5444523
DOI: 10.1038/ng.3413
PMID: 26437030
قاعدة البيانات: MEDLINE
الوصف
تدمد:1546-1718
DOI:10.1038/ng.3413