دورية أكاديمية
Regulation and Function of RFRP-3 (GnIH) Neurons during Postnatal Development.
| العنوان: | Regulation and Function of RFRP-3 (GnIH) Neurons during Postnatal Development. |
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| المؤلفون: | Poling MC; Department of Reproductive Medicine, University of California, San Diego , La Jolla, CA , USA., Kauffman AS; Department of Reproductive Medicine, University of California, San Diego , La Jolla, CA , USA. |
| المصدر: | Frontiers in endocrinology [Front Endocrinol (Lausanne)] 2015 Sep 24; Vol. 6, pp. 150. Date of Electronic Publication: 2015 Sep 24 (Print Publication: 2015). |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101555782 Publication Model: eCollection Cited Medium: Print ISSN: 1664-2392 (Print) Linking ISSN: 16642392 NLM ISO Abbreviation: Front Endocrinol (Lausanne) Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: [Lausanne : Frontiers Research Foundation] |
| مستخلص: | RFamide-related peptide-3 (RFRP-3) [mammalian ortholog to gonadotropin-inhibiting hormone (GnIH)] potently inhibits gonadotropin secretion in mammals. Studies of RFRP-3 immunoreactivity and Rfrp expression (the gene encoding RFRP-3) in mammalian brains have uncovered several possible pathways regulating RFRP-3 neurons, shedding light on their potential role in reproduction and other processes, and pharmacological studies have probed the target sites of RFRP-3 action. Despite this, there is currently no major consensus on RFRP-3's specific endogenous role(s) in reproductive physiology. Here, we discuss the latest evidence relating to RFRP-3 neuron regulation and function during development and sexual maturation, focusing on rodents. We highlight significant changes in RFRP-3 and Rfrp expression, as well as RFRP-3 neuronal activation, during key stages of postnatal and pubertal development and also discuss recent evidence testing the requisite role of RFRP-3 receptors for normal pubertal timing and developmental LH secretion. Interestingly, some findings suggest that endogenous RFRP-3 signaling may not be necessary for the puberty timing, at least in some species, forcing new hypotheses to be generated regarding this peptide's functional significance to sexual maturation and development. |
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| معلومات مُعتمدة: | P50 HD012303 United States HD NICHD NIH HHS; R01 HD065856 United States HD NICHD NIH HHS; U54 HD012303 United States HD NICHD NIH HHS |
| فهرسة مساهمة: | Keywords: GnIH; Gpr147; RFRP-3; Rfrp; development; puberty; reproduction |
| تواريخ الأحداث: | Date Created: 20151007 Date Completed: 20151007 Latest Revision: 20220331 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC4585233 |
| DOI: | 10.3389/fendo.2015.00150 |
| PMID: | 26441840 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1664-2392 |
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| DOI: | 10.3389/fendo.2015.00150 |