دورية أكاديمية
أعرض في EDS

Mitochondrial Damage-Associated Molecular Patterns (MTDs) Are Released during Hepatic Ischemia Reperfusion and Induce Inflammatory Responses.

التفاصيل البيبلوغرافية
العنوان: Mitochondrial Damage-Associated Molecular Patterns (MTDs) Are Released during Hepatic Ischemia Reperfusion and Induce Inflammatory Responses.
المؤلفون: Hu Q; Department of Pathology, Dalhousie University, Halifax, Nova Scotia, Canada., Wood CR; Department of Surgery, Dalhousie University, Halifax, Nova Scotia, Canada., Cimen S; Department of Surgery, Dalhousie University, Halifax, Nova Scotia, Canada., Venkatachalam AB; Department of Surgery, Dalhousie University, Halifax, Nova Scotia, Canada., Alwayn IP; Departments of Surgery, Pathology, Microbiology & Immunology, Dalhousie University, Halifax, Nova Scotia, Canada.
المصدر: PloS one [PLoS One] 2015 Oct 09; Vol. 10 (10), pp. e0140105. Date of Electronic Publication: 2015 Oct 09 (Print Publication: 2015).
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
أسماء مطبوعة: Original Publication: San Francisco, CA : Public Library of Science
مواضيع طبية MeSH: Liver Transplantation*/adverse effects, Cytokines/*metabolism , Ischemia/*metabolism , Liver/*blood supply , Mitochondria/*metabolism , Mitochondria/*pathology , Reperfusion Injury/*metabolism, Animals ; Apoptosis ; Biomarkers/metabolism ; Cell Line ; Cell Survival ; Coculture Techniques ; DNA, Mitochondrial/metabolism ; Hepatocytes/metabolism ; Hepatocytes/pathology ; Humans ; Inflammation/metabolism ; Ischemia/pathology ; Liver/metabolism ; Liver/pathology ; Male ; Rats
مستخلص: Ischemia / reperfusion injury (IRI) during the course of liver transplantation enhances the immunogenicity of allografts and thus impacts overall graft outcome. This sterile inflammatory insult is known to activate innate immunity and propagate organ damage through the recognition of damage-associate molecular pattern (DAMP) molecules. The purpose of the present study was to investigate the role of mitochondrial DAMPs (MTDs) in the pathogenesis of hepatic IRI. Using in vitro models we observed that levels of MTDs were significantly higher in both transplantation-associated and warm IR, and that co-culture of MTDs with human and rat hepatocytes significantly increased cell death. MTDs were also released in an in vivo rat model of hepatic IRI and associated with increased secretion of inflammatory cytokines (TNF-α, IL-6, and IL-10) and increased liver injury compared to the sham group. Our results suggest that hepatic IR results in a significant increase of MTDs both in vitro and in vivo suggesting that MTDs may serve as a novel marker in hepatic IRI. Co-culture of MTDs with hepatocytes showed a decrease in cell viability in a concentration dependent manner, which indicates that MTDs is a toxic mediator participating in the pathogenesis of liver IR injury.
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معلومات مُعتمدة: R03 ES017362 United States ES NIEHS NIH HHS; RES0017362 Canada CAPMC CIHR
المشرفين على المادة: 0 (Biomarkers)
0 (Cytokines)
0 (DNA, Mitochondrial)
تواريخ الأحداث: Date Created: 20151010 Date Completed: 20160706 Latest Revision: 20220318
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC4599831
DOI: 10.1371/journal.pone.0140105
PMID: 26451593
قاعدة البيانات: MEDLINE
الوصف
تدمد:1932-6203
DOI:10.1371/journal.pone.0140105