دورية أكاديمية

What exists beyond cagA and vacA? Helicobacter pylori genes in gastric diseases.

التفاصيل البيبلوغرافية
العنوان: What exists beyond cagA and vacA? Helicobacter pylori genes in gastric diseases.
المؤلفون: da Costa DM; Débora Menezes da Costa, Eliane dos Santos Pereira, Silvia Helena Barem Rabenhorst, Molecular Genetics Laboratory, Department of Pathology and Forensic Medicine, School of Medicine, Federal University of Ceará, Ceará 60430-270, Brazil., Pereira Edos S; Débora Menezes da Costa, Eliane dos Santos Pereira, Silvia Helena Barem Rabenhorst, Molecular Genetics Laboratory, Department of Pathology and Forensic Medicine, School of Medicine, Federal University of Ceará, Ceará 60430-270, Brazil., Rabenhorst SH; Débora Menezes da Costa, Eliane dos Santos Pereira, Silvia Helena Barem Rabenhorst, Molecular Genetics Laboratory, Department of Pathology and Forensic Medicine, School of Medicine, Federal University of Ceará, Ceará 60430-270, Brazil.
المصدر: World journal of gastroenterology [World J Gastroenterol] 2015 Oct 07; Vol. 21 (37), pp. 10563-72.
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: Baishideng Publishing Group Country of Publication: United States NLM ID: 100883448 Publication Model: Print Cited Medium: Internet ISSN: 2219-2840 (Electronic) Linking ISSN: 10079327 NLM ISO Abbreviation: World J Gastroenterol Subsets: MEDLINE
أسماء مطبوعة: Publication: 2014- : Pleasanton, CA : Baishideng Publishing Group
Original Publication: Beijing : WJG Press, c1998-
مواضيع طبية MeSH: Antigens, Bacterial/*genetics , Bacterial Proteins/*genetics , Stomach Diseases/*genetics , Stomach Diseases/*microbiology, Animals ; Bacterial Adhesion ; Bacterial Outer Membrane Proteins/genetics ; Gastritis/microbiology ; Genomic Islands ; Helicobacter Infections/microbiology ; Helicobacter pylori/pathogenicity ; Humans ; Inflammation/microbiology ; Peptic Ulcer/microbiology ; Stomach/microbiology ; Stomach Neoplasms/metabolism ; Stomach Neoplasms/microbiology ; Virulence ; Virulence Factors/genetics
مستخلص: Helicobacter pylori (H. pylori) infection is present in more than half the world's population and has been associated with several gastric disorders, such as gastritis, peptic ulceration, and gastric adenocarcinoma. The clinical outcome of this infection depends on host and bacterial factors where H. pylori virulence genes seem to play a relevant role. Studies of cagA and vacA genes established that they were determining factors in gastric pathogenesis. However, there are gastric cancer cases that are cagA-negative. Several other virulence genes have been searched for, but these genes remain less well known that cagA and vacA. Thus, this review aimed to establish which genes have been suggested as potentially relevant virulence factors for H. pylori-associated gastrointestinal diseases. We focused on the cag-pathogenicity island, genes with adherence and motility functions, and iceA based on the relevance shown in several studies in the literature.
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فهرسة مساهمة: Keywords: Adhesion genes; Cag-pathogenicity island; Helicobacter pylori; Motility genes; Virulence genes
المشرفين على المادة: 0 (Antigens, Bacterial)
0 (Bacterial Outer Membrane Proteins)
0 (Bacterial Proteins)
0 (PicB protein, Helicobacter pylori)
0 (VacA protein, Helicobacter pylori)
0 (Virulence Factors)
0 (cagA protein, Helicobacter pylori)
تواريخ الأحداث: Date Created: 20151013 Date Completed: 20160524 Latest Revision: 20240520
رمز التحديث: 20240520
مُعرف محوري في PubMed: PMC4588078
DOI: 10.3748/wjg.v21.i37.10563
PMID: 26457016
قاعدة البيانات: MEDLINE
الوصف
تدمد:2219-2840
DOI:10.3748/wjg.v21.i37.10563