دورية أكاديمية
أعرض في EDS

Carcinogenic Parasite Secretes Growth Factor That Accelerates Wound Healing and Potentially Promotes Neoplasia.

التفاصيل البيبلوغرافية
العنوان: Carcinogenic Parasite Secretes Growth Factor That Accelerates Wound Healing and Potentially Promotes Neoplasia.
المؤلفون: Smout MJ; Centre for Biodiscovery and Molecular Development of Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook University, Cairns, Queensland, Australia., Sotillo J; Centre for Biodiscovery and Molecular Development of Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook University, Cairns, Queensland, Australia., Laha T; Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand., Papatpremsiri A; Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand., Rinaldi G; Department of Microbiology, Immunology and Tropical Medicine, and Research Center for Neglected Diseases of Poverty, George Washington University, Washington, D.C., United States of America., Pimenta RN; Department of Microbiology, Immunology and Tropical Medicine, and Research Center for Neglected Diseases of Poverty, George Washington University, Washington, D.C., United States of America., Chan LY; The Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia., Johnson MS; Microbial Imaging Facility, The iThree institute, University of Technology Sydney, Ultimo, New South Wales, Australia., Turnbull L; Microbial Imaging Facility, The iThree institute, University of Technology Sydney, Ultimo, New South Wales, Australia., Whitchurch CB; Microbial Imaging Facility, The iThree institute, University of Technology Sydney, Ultimo, New South Wales, Australia., Giacomin PR; Centre for Biodiscovery and Molecular Development of Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook University, Cairns, Queensland, Australia., Moran CS; Queensland Research Centre for Peripheral Vascular Disease, Australian Institute of Tropical Health and Medicine, James Cook University, Cairns, Queensland, Australia., Golledge J; Queensland Research Centre for Peripheral Vascular Disease, Australian Institute of Tropical Health and Medicine, James Cook University, Cairns, Queensland, Australia; Department of Vascular and Endovascular Surgery, The Townsville Hospital, Townsville, Queensland, Australia., Daly N; Centre for Biodiscovery and Molecular Development of Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook University, Cairns, Queensland, Australia., Sripa B; Department of Pathology, Khon Kaen University, Khon Kaen, Thailand., Mulvenna JP; QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia., Brindley PJ; Department of Microbiology, Immunology and Tropical Medicine, and Research Center for Neglected Diseases of Poverty, George Washington University, Washington, D.C., United States of America., Loukas A; Centre for Biodiscovery and Molecular Development of Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook University, Cairns, Queensland, Australia.
المصدر: PLoS pathogens [PLoS Pathog] 2015 Oct 20; Vol. 11 (10), pp. e1005209. Date of Electronic Publication: 2015 Oct 20 (Print Publication: 2015).
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101238921 Publication Model: eCollection Cited Medium: Internet ISSN: 1553-7374 (Electronic) Linking ISSN: 15537366 NLM ISO Abbreviation: PLoS Pathog Subsets: MEDLINE
أسماء مطبوعة: Original Publication: San Francisco, CA : Public Library of Science, c2005-
مواضيع طبية MeSH: Carcinogenesis/*metabolism , Helminth Proteins/*metabolism , Intercellular Signaling Peptides and Proteins/*metabolism , Opisthorchiasis/*complications , Opisthorchis/*metabolism , Wound Healing/*physiology, Amino Acid Sequence ; Animals ; Bile Duct Neoplasms/parasitology ; Cholangiocarcinoma/parasitology ; Humans ; Mice ; Microscopy, Confocal ; Molecular Sequence Data ; Oligonucleotide Array Sequence Analysis ; Opisthorchiasis/metabolism ; Progranulins ; RNA Interference
مستخلص: Infection with the human liver fluke Opisthorchis viverrini induces cancer of the bile ducts, cholangiocarcinoma (CCA). Injury from feeding activities of this parasite within the human biliary tree causes extensive lesions, wounds that undergo protracted cycles of healing, and re-injury over years of chronic infection. We show that O. viverrini secreted proteins accelerated wound resolution in human cholangiocytes, an outcome that was compromised following silencing of expression of the fluke-derived gene encoding the granulin-like growth factor, Ov-GRN-1. Recombinant Ov-GRN-1 induced angiogenesis and accelerated mouse wound healing. Ov-GRN-1 was internalized by human cholangiocytes and induced gene and protein expression changes associated with wound healing and cancer pathways. Given the notable but seemingly paradoxical properties of liver fluke granulin in promoting not only wound healing but also a carcinogenic microenvironment, Ov-GRN-1 likely holds marked potential as a therapeutic wound-healing agent and as a vaccine against an infection-induced cancer of major public health significance in the developing world.
References: Trends Parasitol. 2012 Oct;28(10):395-407. (PMID: 22947297)
Nucleic Acids Res. 2013 Jan;41(Database issue):D808-15. (PMID: 23203871)
Angiogenesis. 2013 Jul;16(3):493-502. (PMID: 23417553)
PLoS One. 2013;8(8):e72107. (PMID: 24009671)
Clin Cancer Res. 2013 Nov 15;19(22):6064-6. (PMID: 24097858)
Clin Podiatr Med Surg. 2014 Jan;31(1):27-42. (PMID: 24296016)
J Allergy Clin Immunol. 2015 Feb;135(2):508-16. (PMID: 25248819)
Expert Opin Drug Metab Toxicol. 2015 May;11(5):673-89. (PMID: 25495223)
Int J Parasitol. 2000 May;30(6):735-40. (PMID: 10856508)
Anal Chem. 2002 Oct 15;74(20):5383-92. (PMID: 12403597)
Nat Struct Mol Biol. 2014 Feb;21(2):189-97. (PMID: 24440982)
Expert Rev Clin Immunol. 2014 May;10(5):593-619. (PMID: 24678812)
Nat Commun. 2014;5:4378. (PMID: 25007141)
Adv Exp Med Biol. 2014;825:267-302. (PMID: 25201109)
Mol Cell Proteomics. 2014 Oct;13(10):2736-51. (PMID: 24994561)
J Cell Biol. 2014 Oct 27;207(2):167-9. (PMID: 25349256)
Physiol Rev. 2003 Jan;83(1):163-82. (PMID: 12506129)
Anal Chem. 2003 Sep 1;75(17):4646-58. (PMID: 14632076)
Proc Natl Acad Sci U S A. 2014 Nov 4;111(44):E4762-8. (PMID: 25341731)
PLoS One. 2014;9(11):e112110. (PMID: 25393765)
Lancet Infect Dis. 2014 Nov;14(11):1150-62. (PMID: 24981042)
Cancer Immunol Res. 2014 Dec;2(12):1209-19. (PMID: 25315249)
J Proteomics. 2015 Jan 15;113:281-91. (PMID: 25284051)
Exp Parasitol. 2015 Jan;148:17-23. (PMID: 25450776)
J Infect Dis. 2015 Feb 1;211(3):416-25. (PMID: 25139017)
Trop Med Int Health. 2004 May;9(5):588-94. (PMID: 15117303)
Transplantation. 2004 May 15;77(9):1357-65. (PMID: 15167590)
J Am Coll Surg. 2004 Oct;199(4):578-85. (PMID: 15454143)
Am J Physiol. 1994 Jun;266(6 Pt 1):G1060-70. (PMID: 8023938)
Chem Res Toxicol. 2005 Feb;18(2):154-61. (PMID: 15720119)
CA Cancer J Clin. 2005 Mar-Apr;55(2):74-108. (PMID: 15761078)
Clin Cancer Res. 2005 Apr 1;11(7):2702-12. (PMID: 15814652)
World J Gastroenterol. 2005 May 14;11(18):2748-53. (PMID: 15884115)
Protein Expr Purif. 2005 May;41(1):207-34. (PMID: 15915565)
BMC Genomics. 2005;6:145. (PMID: 16242023)
J Exp Med. 2005 Nov 7;202(9):1199-212. (PMID: 16275759)
Brief Funct Genomic Proteomic. 2006 Jun;5(2):112-20. (PMID: 16772272)
Nat Protoc. 2007;2(2):329-33. (PMID: 17406593)
PLoS Med. 2007 Jul;4(7):e201. (PMID: 17622191)
Oncogene. 2007 Dec 13;26(57):7825-32. (PMID: 17599048)
Cytokine. 2008 Apr;42(1):1-7. (PMID: 18249132)
Hepatology. 2008 May;47(5):1524-32. (PMID: 18393387)
Science. 2008 Jun 6;320(5881):1332-6. (PMID: 18535242)
Nat Protoc. 2008;3(6):1101-8. (PMID: 18546601)
Nat Rev Mol Cell Biol. 2008 Aug;9(8):628-38. (PMID: 18628784)
Int Rev Cell Mol Biol. 2008;270:181-224. (PMID: 19081537)
Mol Cell Proteomics. 2009 Jan;8(1):109-21. (PMID: 18753127)
PLoS Pathog. 2009 Oct;5(10):e1000611. (PMID: 19816559)
Bioessays. 2009 Nov;31(11):1245-54. (PMID: 19795409)
J Cell Physiol. 2010 Apr;223(1):224-33. (PMID: 20054825)
J Cereb Blood Flow Metab. 2010 Mar;30(3):459-73. (PMID: 19904283)
Proteomics. 2010 Mar;10(5):1063-78. (PMID: 20049860)
Proteomics. 2010 Mar;10(6):1265-9. (PMID: 20077414)
Endocr Relat Cancer. 2010 Dec;17(4):929-40. (PMID: 20702723)
Neuron. 2010 Nov 18;68(4):654-67. (PMID: 21092856)
J Biomed Biotechnol. 2011;2011:969618. (PMID: 21151647)
Mol Biosyst. 2011 May;7(5):1367-75. (PMID: 21311794)
Immunity. 2011 Apr 22;34(4):505-13. (PMID: 21497117)
Science. 2011 Apr 22;332(6028):478-84. (PMID: 21393509)
PLoS One. 2011;6(6):e21023. (PMID: 21698296)
Parasitol Int. 2011 Sep;60(3):283-8. (PMID: 21565281)
Protein Expr Purif. 2011 Oct;79(2):263-70. (PMID: 21757010)
J Mol Neurosci. 2011 Nov;45(3):549-60. (PMID: 21611805)
Blood. 2011 Dec 15;118(25):6709-17. (PMID: 22039263)
Biochim Biophys Acta. 2012 Jan;1825(1):117-29. (PMID: 22079531)
Methods Mol Biol. 2012;843:47-57. (PMID: 22222520)
J Biochem. 2012 Jun;151(6):563-71. (PMID: 22528665)
J Immunol. 2012 Sep 15;189(6):2824-32. (PMID: 22869904)
PLoS Biol. 2012;10(9):e1001389. (PMID: 22984350)
J Biol Chem. 2012 Sep 21;287(39):32298-306. (PMID: 22859297)
معلومات مُعتمدة: P50 AI098639 United States AI NIAID NIH HHS; R01 CA164719 United States CA NCI NIH HHS; P50AI098639 United States AI NIAID NIH HHS; R01CA164719 United States CA NCI NIH HHS
المشرفين على المادة: 0 (Helminth Proteins)
0 (Intercellular Signaling Peptides and Proteins)
0 (Progranulins)
تواريخ الأحداث: Date Created: 20151021 Date Completed: 20160429 Latest Revision: 20190202
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC4618121
DOI: 10.1371/journal.ppat.1005209
PMID: 26485648
قاعدة البيانات: MEDLINE
الوصف
تدمد:1553-7374
DOI:10.1371/journal.ppat.1005209