دورية أكاديمية
أعرض في EDS

Markers of Bone Metabolism in Patients With Chronic Pancreatitis and Pancreatic Ductal Adenocarcinoma.

التفاصيل البيبلوغرافية
العنوان: Markers of Bone Metabolism in Patients With Chronic Pancreatitis and Pancreatic Ductal Adenocarcinoma.
المؤلفون: Pezzilli R; From the Pancreas Unit, Department of Digestive System, Sant'Orsola-Malpighi Hospital, Bologna, Italy (RP); and Department of Health Sciences, University of Milan, Milan, Italy Bologna, Italy (ME, AB)., Melzi d'Eril GV, Barassi A
المصدر: Medicine [Medicine (Baltimore)] 2015 Oct; Vol. 94 (42), pp. e1754.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 2985248R Publication Model: Print Cited Medium: Internet ISSN: 1536-5964 (Electronic) Linking ISSN: 00257974 NLM ISO Abbreviation: Medicine (Baltimore) Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Hagerstown, Md : Lippincott Williams & Wilkins
مواضيع طبية MeSH: Bone and Bones/*metabolism , Carcinoma, Pancreatic Ductal/*blood , Pancreatic Neoplasms/*blood , Vitamin D/*analogs & derivatives, Age Factors ; Aged ; Alcohol Drinking ; Body Mass Index ; Calcium/blood ; Carcinoma, Pancreatic Ductal/complications ; Chronic Disease ; Exocrine Pancreatic Insufficiency/complications ; Female ; Humans ; Luminescent Measurements ; Male ; Middle Aged ; Pancreatic Neoplasms/complications ; Parathyroid Hormone/blood ; Smoking/epidemiology ; Vitamin D/blood
مستخلص: There are no studies comparing some of the most important markers, such as vitamin D, parathormone, osteocalcin, bone alkaline phosphatase, and calcium, in patients with chronic benign and malignant pancreatic diseases. Our objective was to comparatively evaluate serum markers of bone metabolism in patients with chronic pancreatitis and in those with ductal pancreatic adenocarcinoma. Sixty-three consecutive subjects were studied: 30 patients with a firm diagnosis of chronic pancreatitis and 33 having histologically confirmed pancreatic adenocarcinoma. Serum 25-hydroxyvitamin D, bone alkaline phosphatase, osteocalcin, parathormone, and calcium were determined using commercially available kits. Taking into consideration the clinical variables of all 63 patients studied, 25-hydroxyvitamin D was inversely correlated with only the body mass index (P = 0.007), whereas it was not correlated with age (P = 0.583) or fecal elastase-1 concentrations (P = 0.556). Regarding the other substances studied, parathormone was positively correlated with only the age of the patients (P = 0.015). Of the 5 substances studied, only bone alkaline phosphates were significantly different (P < 0.001) between patients with chronic pancreatitis and those with pancreatic ductal adenocarcinoma. Within the 2 groups of patients, the 23 patients with chronic pancreatitis without diabetes mellitus had serum concentrations of 25-hydroxyvitamin D significantly lower (P = 0.045) than those with chronic pancreatitis having diabetes mellitus, whereas smokers with pancreatic ductal adenocarcinoma had serum concentrations of calcium significantly higher (P < 0.001) as compared to nonsmokers. Altered bone metabolism seems to be associated with chronic diseases of the pancreas; however, the mechanism should be better elucidated.
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المشرفين على المادة: 0 (Parathyroid Hormone)
1406-16-2 (Vitamin D)
A288AR3C9H (25-hydroxyvitamin D)
SY7Q814VUP (Calcium)
تواريخ الأحداث: Date Created: 20151027 Date Completed: 20160211 Latest Revision: 20221005
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC4620801
DOI: 10.1097/MD.0000000000001754
PMID: 26496293
قاعدة البيانات: MEDLINE
الوصف
تدمد:1536-5964
DOI:10.1097/MD.0000000000001754