دورية أكاديمية

Assessing and monitoring intratumor heterogeneity in glioblastoma: how far has multimodal imaging come?

التفاصيل البيبلوغرافية
العنوان: Assessing and monitoring intratumor heterogeneity in glioblastoma: how far has multimodal imaging come?
المؤلفون: Boonzaier NR; Cambridge Brain Tumour Imaging Laboratory, Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 0QQ, UK.; Wolfson Brain Imaging Centre, Department of Clinical Neurosciences, Cambridge Biomedical Campus, University of Cambridge, Cambridge CB2 0QQ, UK., Piccirillo SG; Cambridge Centre for Brain Repair, Department of Clinical Neurosciences, Forvie Site, Robinson Way, Cambridge CB2 0PY, UK., Watts C; Cambridge Brain Tumour Imaging Laboratory, Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 0QQ, UK., Price SJ; Cambridge Brain Tumour Imaging Laboratory, Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 0QQ, UK.; Wolfson Brain Imaging Centre, Department of Clinical Neurosciences, Cambridge Biomedical Campus, University of Cambridge, Cambridge CB2 0QQ, UK.
المصدر: CNS oncology [CNS Oncol] 2015; Vol. 4 (6), pp. 399-410. Date of Electronic Publication: 2015 Oct 26.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Review
اللغة: English
بيانات الدورية: Publisher: Future Medicine Country of Publication: England NLM ID: 101594668 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2045-0915 (Electronic) Linking ISSN: 20450907 NLM ISO Abbreviation: CNS Oncol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : Future Medicine, 2012-
مواضيع طبية MeSH: Brain Neoplasms/*pathology , Glioblastoma/*pathology , Multimodal Imaging/*methods, Animals ; Brain Neoplasms/therapy ; Glioblastoma/therapy ; Humans
مستخلص: Glioblastoma demonstrates imaging features of intratumor heterogeneity that result from underlying heterogeneous biological properties. This stems from variations in cellular behavior that result from genetic mutations that either drive, or are driven by, heterogeneous microenvironment conditions. Among all imaging methods available, only T1-weighted contrast-enhancing and T2-weighted fluid-attenuated inversion recovery are used in standard clinical glioblastoma assessment and monitoring. Advanced imaging modalities are still considered emerging techniques as appropriate end points and robust methodologies are missing from clinical trials. Discovering how these images specifically relate to the underlying tumor biology may aid in improving quality of clinical trials and understanding the factors involved in regional responses to treatment, including variable drug uptake and effect of radiotherapy. Upon validation and standardization of emerging MR techniques, providing information based on the underlying tumor biology, these images may allow for clinical decision-making that is tailored to an individual's response to treatment.
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معلومات مُعتمدة: NIHR/CS/009/011 United Kingdom DH_ Department of Health; United Kingdom CRUK_ Cancer Research UK
فهرسة مساهمة: Keywords: advanced imaging; glioblastoma; intratumor heterogeneity; subregional assessment; underlying biology
تواريخ الأحداث: Date Created: 20151027 Date Completed: 20160823 Latest Revision: 20220129
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC6083939
DOI: 10.2217/cns.15.20
PMID: 26497327
قاعدة البيانات: MEDLINE
الوصف
تدمد:2045-0915
DOI:10.2217/cns.15.20