دورية أكاديمية
Relationship of interleukin-1B gene promoter region polymorphism with Helicobacter pylori infection and gastritis.
| العنوان: | Relationship of interleukin-1B gene promoter region polymorphism with Helicobacter pylori infection and gastritis. |
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| المؤلفون: | Ramis IB; Universidade Federal de Pelotas (UFPel), Pelotas, Rio Grande do Sul, Brasil. ivynha_@hotmail.com., Vianna JS, Halicki PC, Lara C, Tadiotto TF, da Silva Maciel JB, Gonçalves CV, von Groll A, Dellagostin OA, da Silva PE |
| المصدر: | Journal of infection in developing countries [J Infect Dev Ctries] 2015 Sep 29; Vol. 9 (10), pp. 1108-16. Date of Electronic Publication: 2015 Sep 29. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Open Learning on Enteric Pathogens Country of Publication: Italy NLM ID: 101305410 Publication Model: Electronic Cited Medium: Internet ISSN: 1972-2680 (Electronic) Linking ISSN: 19722680 NLM ISO Abbreviation: J Infect Dev Ctries Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [Italy?] : Open Learning on Enteric Pathogens |
| مواضيع طبية MeSH: | Polymorphism, Genetic* , Promoter Regions, Genetic*, Gastritis/*genetics , Gastritis/*immunology , Helicobacter Infections/*genetics , Helicobacter Infections/*immunology , Interleukin-1beta/*genetics, Biopsy ; Female ; Gastric Mucosa/microbiology ; Gastric Mucosa/pathology ; Helicobacter pylori/immunology ; Helicobacter pylori/isolation & purification ; Histocytochemistry ; Humans ; Interleukin 1 Receptor Antagonist Protein/genetics ; Male ; Middle Aged ; Polymerase Chain Reaction ; Polymorphism, Restriction Fragment Length |
| مستخلص: | Introduction: Helicobacter pylori infection is associated with gastritis, peptic ulcer disease and gastric carcinoma. The severity of damage is determined by the interplay between environmental/behavioral factors, bacterial pathogenicity genes and host genetic polymorphisms that can influence the secretion levels of inflammatory cytokines. Accordingly, this study aimed to identify polymorphisms in the IL-1B and IL-1RN genes and their associations with H. pylori infection, cagA gene of H. pylori, and gastroduodenal diseases. Methodology: Gastric biopsy samples from 151 patients infected with H. pylori and 76 uninfected individuals were analyzed. H. pylori infection was diagnosed by histology and PCR. Polymorphisms at positions -511, -31 and +3954 of the IL-1B gene were detected by PCR-RFLP, and an analysis of the VNTR polymorphism of the IL-1RN gene was performed by PCR. Results: It was observed that the presence of the T/T genotype at position -511 and the C/C genotype at position -31 were associated with H. pylori infection and with an increased risk of gastritis in H. pylori-positive patients. Additionally, strains from patients H. pylori-positive carrying the cagA gene was significantly related with the T/T genotype at position -511 of IL-1B. No association of polymorphisms at position +3954 of IL-1B and in the IL-1RN with H. pylori infection and with risk of severe gastric diseases was found. Conclusions: We demonstrated that polymorphisms in the promoter region of the IL-1B gene (at positions -511 and -31) are associated with an enhanced risk of H. pylori infection as well as gastritis in H. pylori-positive patients. |
| المشرفين على المادة: | 0 (IL1RN protein, human) 0 (Interleukin 1 Receptor Antagonist Protein) 0 (Interleukin-1beta) |
| تواريخ الأحداث: | Date Created: 20151031 Date Completed: 20160812 Latest Revision: 20220321 |
| رمز التحديث: | 20240628 |
| DOI: | 10.3855/jidc.6123 |
| PMID: | 26517486 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1972-2680 |
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| DOI: | 10.3855/jidc.6123 |