دورية أكاديمية
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Opioid pathways activation mediates the activity of nicorandil in experimental models of nociceptive and inflammatory pain.

التفاصيل البيبلوغرافية
العنوان: Opioid pathways activation mediates the activity of nicorandil in experimental models of nociceptive and inflammatory pain.
المؤلفون: Dutra MM; Departamento de Produtos Farmacêuticos, Faculdade de Farmácia, Universidade Federal de Minas Gerais, Avenida Antônio Carlos, 6627, CEP 31270-901 Belo Horizonte, MG, Brazil; Centro Universitário Newton Paiva, Avenida Silva Lobo, 1730, CEP 30460-000, Belo Horizonte, MG, Brazil., Nascimento Júnior EB; Universidade Federal do Piauí, Avenida São Sebastião, 2819, CEP 64202-020 Parnaíba, PI, Brazil., Godin AM; Departamento de Produtos Farmacêuticos, Faculdade de Farmácia, Universidade Federal de Minas Gerais, Avenida Antônio Carlos, 6627, CEP 31270-901 Belo Horizonte, MG, Brazil., Brito AM; Departamento de Produtos Farmacêuticos, Faculdade de Farmácia, Universidade Federal de Minas Gerais, Avenida Antônio Carlos, 6627, CEP 31270-901 Belo Horizonte, MG, Brazil., Melo IS; Departamento de Produtos Farmacêuticos, Faculdade de Farmácia, Universidade Federal de Minas Gerais, Avenida Antônio Carlos, 6627, CEP 31270-901 Belo Horizonte, MG, Brazil., Augusto PS; Departamento de Produtos Farmacêuticos, Faculdade de Farmácia, Universidade Federal de Minas Gerais, Avenida Antônio Carlos, 6627, CEP 31270-901 Belo Horizonte, MG, Brazil., Rodrigues FF; Departamento de Produtos Farmacêuticos, Faculdade de Farmácia, Universidade Federal de Minas Gerais, Avenida Antônio Carlos, 6627, CEP 31270-901 Belo Horizonte, MG, Brazil., Araújo DP; Departamento de Química, Instituto de Ciências Exatas, Universidade Federal de Minas Gerais, Avenida Antônio Carlos, 6627, CEP 31270-901 Belo Horizonte, MG, Brazil., de Fátima Â; Departamento de Química, Instituto de Ciências Exatas, Universidade Federal de Minas Gerais, Avenida Antônio Carlos, 6627, CEP 31270-901 Belo Horizonte, MG, Brazil., Coelho MM; Departamento de Produtos Farmacêuticos, Faculdade de Farmácia, Universidade Federal de Minas Gerais, Avenida Antônio Carlos, 6627, CEP 31270-901 Belo Horizonte, MG, Brazil., Machado RR; Departamento de Produtos Farmacêuticos, Faculdade de Farmácia, Universidade Federal de Minas Gerais, Avenida Antônio Carlos, 6627, CEP 31270-901 Belo Horizonte, MG, Brazil. Electronic address: rrm_farmacia@hotmail.com.
المصدر: European journal of pharmacology [Eur J Pharmacol] 2015 Dec 05; Vol. 768, pp. 160-4. Date of Electronic Publication: 2015 Oct 29.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 1254354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0712 (Electronic) Linking ISSN: 00142999 NLM ISO Abbreviation: Eur J Pharmacol Subsets: MEDLINE
أسماء مطبوعة: Publication: 2005- : Amsterdam : Elsevier Science
Original Publication: Amsterdam, North Holland Pub. Co.
مواضيع طبية MeSH: Analgesics/*metabolism , Analgesics/*pharmacology , Nicorandil/*metabolism , Nicorandil/*pharmacology , Nociceptive Pain/*drug therapy , Nociceptive Pain/*pathology , Signal Transduction/*drug effects, Analgesics/therapeutic use ; Animals ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Inflammation/complications ; Inflammation/drug therapy ; Inflammation/pathology ; Male ; Mice ; Nicorandil/therapeutic use
مستخلص: We have previously demonstrated that nicorandil inhibits the second phase of the nociceptive response induced by formaldehyde. In the present study, we evaluated the effects induced by nicorandil in other models of nociceptive and inflammatory pain in mice and also whether opioid pathways activation mediates its activity. As we have previously demonstrated, per os (p.o.) administration of nicorandil (50, 100 or 150mg/kg; -1h) inhibited the second phase of the nociceptive response induced by intraplantar (i.pl.) injection of formaldehyde. Nicorandil (50, 100 or 150mg/kg; p.o., -1h) also exhibited activity in models of inflammatory pain induced by i.pl. injection of carrageenan (300μg) and nociceptive pain induced by exposure to noxious heat (50°C). Intraperitoneal (i.p.) administration of the opioid antagonist naltrexone (1, 5 or 10mg/kg, -30min) attenuated or abolished the antinociceptive activity of nicorandil (100mg/kg, p.o.) in the three experimental pain models. In conclusion, we demonstrate that nicorandil exhibits activity in different models of nociceptive and inflammatory pain. The demonstration that the antinociceptive effect induced by nicorandil is markedly attenuated by an opioid antagonist provides solid information about an important mechanism mediating the activity of this antianginal drug. Altogether, our data suggest that the clinical pain relief induced by nicorandil in heart ischemic conditions may result from both vasodilation and intrinsic analgesic activity.
(Copyright © 2015. Published by Elsevier B.V.)
فهرسة مساهمة: Keywords: Antinociception; Inflammation; Naltrexone; Nicorandil; Opioid pathways; Pain
المشرفين على المادة: 0 (Analgesics)
260456HAM0 (Nicorandil)
تواريخ الأحداث: Date Created: 20151103 Date Completed: 20160913 Latest Revision: 20151121
رمز التحديث: 20240628
DOI: 10.1016/j.ejphar.2015.10.047
PMID: 26522924
قاعدة البيانات: MEDLINE
الوصف
تدمد:1879-0712
DOI:10.1016/j.ejphar.2015.10.047