دورية أكاديمية
[Relation of MBL ExonI 54 and NFκB1-94ins/del ATTG Polymorphism with Fever during Neutropenia in Patients with Acute Leukaemia after Chemotherapy].
| العنوان: | [Relation of MBL ExonI 54 and NFκB1-94ins/del ATTG Polymorphism with Fever during Neutropenia in Patients with Acute Leukaemia after Chemotherapy]. |
|---|---|
| المؤلفون: | Xu WN; Department of Hematology, Guangzhou General Hospital of Guangzhou Military Command, Guangdong Province, Guangzhou 510010, China.; Department of Hematology, The First People Hospital of Foshan Municipality, Guangdong Province, Foshan 528000, China., Jiang ZJ; Department of Hematology, Guangzhou General Hospital of Guangzhou Military Command, Guangdong Province, Guangzhou 510010, China., Li YH; Department of Hematology, Guangzhou General Hospital of Guangzhou Military Command, Guangdong Province, Guangzhou 510010, China., Xiao HW; Department of Hematology, Guangzhou General Hospital of Guangzhou Military Command, Guangdong Province, Guangzhou 510010, China., Gao Y; Department of Hematology, Guangzhou General Hospital of Guangzhou Military Command, Guangdong Province, Guangzhou 510010, China., Pang Y; Department of Hematology, Guangzhou General Hospital of Guangzhou Military Command, Guangdong Province, Guangzhou 510010, China., Ouyang L; Department of Hematology, Guangzhou General Hospital of Guangzhou Military Command, Guangdong Province, Guangzhou 510010, China., Liu ZH; Department of Hematology, Guangzhou General Hospital of Guangzhou Military Command, Guangdong Province, Guangzhou 510010, China., Zhang LQ; Department of Hematology, Guangzhou General Hospital of Guangzhou Military Command, Guangdong Province, Guangzhou 510010, China., Wang Y; Department of Hematology, Guangzhou General Hospital of Guangzhou Military Command, Guangdong Province, Guangzhou 510010, China., Xiao Y; Department of Hematology, Guangzhou General Hospital of Guangzhou Military Command, Guangdong Province, Guangzhou 510010, China. E-mail: jdxiao111@163.com. |
| المصدر: | Zhongguo shi yan xue ye xue za zhi [Zhongguo Shi Yan Xue Ye Xue Za Zhi] 2015 Oct; Vol. 23 (5), pp. 1258-64. |
| نوع المنشور: | Journal Article |
| اللغة: | Chinese |
| بيانات الدورية: | Publisher: Zhongguo shi yan xue za zhi she Country of Publication: China NLM ID: 101084424 Publication Model: Print Cited Medium: Print ISSN: 1009-2137 (Print) Linking ISSN: 10092137 NLM ISO Abbreviation: Zhongguo Shi Yan Xue Ye Xue Za Zhi Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Beijing : Zhongguo shi yan xue za zhi she, |
| مواضيع طبية MeSH: | INDEL Mutation* , Neutropenia*, Leukemia/*genetics , Mannose-Binding Lectin/*genetics , NF-kappa B p50 Subunit/*genetics, Acute Disease ; Exons ; Fever ; Genotype ; Humans ; Leukemia/drug therapy ; Polymorphism, Single Nucleotide |
| مستخلص: | Objective: To explore the correlation between MBL ExonI 54 and NFκB1-94ins/del ATTG polymorphism and fever during neutropenia in patients with acute leukaemia (AL) (except M3) after first chemotherapy in Chinese Han population. Methods: Blood samples obtained from 76 fever patients with AL during neutropenia episodes were detected to analyse single nucleotide polymorphism (SNP) in the MBL ExonI 54 and NFκB1-94ins/del ATTG gene, and analyse the correlation between above-mentioned 2 polymorphisms and fever during neutropenia of AL patients after chemotherapy. Results: In 76 patients, no correlation were found between MBL ExonI 54 and NFκB1-94ins/del ATTG polymorphism and fever during neutropenia in patients with acute leukaemia after chemotherapy (P > 0.05). No significant relation were found in sex, age, underlying disease, disease status or degrees of neutropenia in febrile neutropenia between MBL ExonI 54 and NFκB1-94ins/del ATTG polymorphism (P > 0.05). However, patients with MBL ExonI 54 mutation presented longer febrile duration with a median of 5 days compared to 3 days of patients with wildtype MBL ExonI 54 genotype (P < 0.05). Conclusions: There is no clear correlation between MBL ExonI 54 and NFκB1-94ins/del ATTG polymorphism and fever during neutropenia in patients with acute leukaemia after chemotherapy. However, the patients with MBL ExonI 54 mutation have been observed to present a longer febrile duration. |
| المشرفين على المادة: | 0 (Mannose-Binding Lectin) 0 (NF-kappa B p50 Subunit) 0 (NFKB1 protein, human) |
| تواريخ الأحداث: | Date Created: 20151103 Date Completed: 20160125 Latest Revision: 20181202 |
| رمز التحديث: | 20240628 |
| DOI: | 10.7534/j.issn.1009-2137.2015.05.007 |
| PMID: | 26524019 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1009-2137 |
|---|---|
| DOI: | 10.7534/j.issn.1009-2137.2015.05.007 |