دورية أكاديمية
أعرض في EDS

Bisphenol-A promotes antiproliferative effects during neonatal prostate development in male and female gerbils.

التفاصيل البيبلوغرافية
العنوان: Bisphenol-A promotes antiproliferative effects during neonatal prostate development in male and female gerbils.
المؤلفون: de Lima RF; Department of Histology, Embryology and Cell Biology, Federal University of Goiás, Samambaia II, Goiânia, Goiás 74001970, Brazil., Rodriguez DA; Department of Histology, Embryology and Cell Biology, Federal University of Goiás, Samambaia II, Goiânia, Goiás 74001970, Brazil., Campos MS; São Paulo State University - UNESP, Department of Biology, Laboratory of Microscopy and Microanalysis, Rua Cristóvão Colombo, 2265, São José do Rio Preto, São Paulo 15054000, Brazil., Biancardi MF; Department of Histology, Embryology and Cell Biology, Federal University of Goiás, Samambaia II, Goiânia, Goiás 74001970, Brazil., dos Santos IF; Department of Histology, Embryology and Cell Biology, Federal University of Goiás, Samambaia II, Goiânia, Goiás 74001970, Brazil., de Oliveira WD; Department of Histology, Embryology and Cell Biology, Federal University of Goiás, Samambaia II, Goiânia, Goiás 74001970, Brazil., Cavasin GM; Department of Histology, Embryology and Cell Biology, Federal University of Goiás, Samambaia II, Goiânia, Goiás 74001970, Brazil., Marques MR; Department of Histology, Embryology and Cell Biology, Federal University of Goiás, Samambaia II, Goiânia, Goiás 74001970, Brazil., Taboga SR; São Paulo State University - UNESP, Department of Biology, Laboratory of Microscopy and Microanalysis, Rua Cristóvão Colombo, 2265, São José do Rio Preto, São Paulo 15054000, Brazil., Santos FC; Department of Histology, Embryology and Cell Biology, Federal University of Goiás, Samambaia II, Goiânia, Goiás 74001970, Brazil. Electronic address: fernanda_alcantara@ufg.br.
المصدر: Reproductive toxicology (Elmsford, N.Y.) [Reprod Toxicol] 2015 Dec; Vol. 58, pp. 238-45. Date of Electronic Publication: 2015 Oct 31.
نوع المنشور: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Pergamon In Cooperation With The Reproductive Toxicology Center Country of Publication: United States NLM ID: 8803591 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-1708 (Electronic) Linking ISSN: 08906238 NLM ISO Abbreviation: Reprod Toxicol Subsets: MEDLINE
أسماء مطبوعة: Publication: Elmsford Ny : Pergamon In Cooperation With The Reproductive Toxicology Center
Original Publication: Elmsford, N.Y., U.S.A. : Pergamon Press, c1987-
مواضيع طبية MeSH: Benzhydryl Compounds/*toxicity , Cell Proliferation/*drug effects , Endocrine Disruptors/*toxicity , Phenols/*toxicity , Prostate/*drug effects, Actins/metabolism ; Animals ; Animals, Newborn ; Biomarkers/metabolism ; Dose-Response Relationship, Drug ; Estrogen Receptor alpha/metabolism ; Female ; Gerbillinae ; Imaging, Three-Dimensional ; Immunohistochemistry ; Male ; Proliferating Cell Nuclear Antigen/metabolism ; Prostate/growth & development ; Prostate/metabolism ; Prostate/pathology ; Sex Factors
مستخلص: The aim of this study was to evaluate the development of male and female neonatal gerbil prostate under normal conditions and exposed to bisphenol-A (BPA). Normal postnatal development of the female gerbil prostate occurs earlier than and is morphologically distinct from that occurring in males. In BPA-exposed PND8 gerbils, we have not observed evidence of alterations in the ductal branching in either gender. However, the exposure to BPA alters the immunolabeling pattern of AR, ERα, and PCNA. In males, the exposure to high dosages of BPA resulted in a decrease in the proliferative status of the developing ventral prostate. In females, both high and low dosages were sufficient to decrease the proliferation of paraurethral buds in the branching process by more than 50%. Therefore, the obtained data indicate that BPA promotes antiproliferative effects during the neonatal development of the gerbil prostate, with more sensitivity to this endocrine disruptor in females.
(Copyright © 2015 Elsevier Inc. All rights reserved.)
فهرسة مساهمة: Keywords: AR antagonists; Endocrine-disrupting chemicals; Gerbil; Prostatic morphogenesis
المشرفين على المادة: 0 (Actins)
0 (Benzhydryl Compounds)
0 (Biomarkers)
0 (Endocrine Disruptors)
0 (Estrogen Receptor alpha)
0 (Phenols)
0 (Proliferating Cell Nuclear Antigen)
MLT3645I99 (bisphenol A)
تواريخ الأحداث: Date Created: 20151104 Date Completed: 20160926 Latest Revision: 20151224
رمز التحديث: 20240628
DOI: 10.1016/j.reprotox.2015.10.016
PMID: 26529182
قاعدة البيانات: MEDLINE
الوصف
تدمد:1873-1708
DOI:10.1016/j.reprotox.2015.10.016