دورية أكاديمية
أعرض في EDS

Oral supplementations with L-glutamine or L-alanyl-L-glutamine do not change metabolic alterations induced by long-term high-fat diet in the B6.129F2/J mouse model of insulin resistance.

التفاصيل البيبلوغرافية
العنوان: Oral supplementations with L-glutamine or L-alanyl-L-glutamine do not change metabolic alterations induced by long-term high-fat diet in the B6.129F2/J mouse model of insulin resistance.
المؤلفون: Bock PM; Laboratory of Cellular Physiology, Department of Physiology, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Rua Sarmento Leite, 500, 2nd floor, suite 350, Porto Alegre, RS, 90050-170, Brazil., Krause M; Laboratory of Cellular Physiology, Department of Physiology, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Rua Sarmento Leite, 500, 2nd floor, suite 350, Porto Alegre, RS, 90050-170, Brazil., Schroeder HT; Laboratory of Cellular Physiology, Department of Physiology, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Rua Sarmento Leite, 500, 2nd floor, suite 350, Porto Alegre, RS, 90050-170, Brazil., Hahn GF; Laboratory of Cellular Physiology, Department of Physiology, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Rua Sarmento Leite, 500, 2nd floor, suite 350, Porto Alegre, RS, 90050-170, Brazil., Takahashi HK; Laboratory of Cellular Physiology, Department of Physiology, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Rua Sarmento Leite, 500, 2nd floor, suite 350, Porto Alegre, RS, 90050-170, Brazil., Schöler CM; Laboratory of Cellular Physiology, Department of Physiology, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Rua Sarmento Leite, 500, 2nd floor, suite 350, Porto Alegre, RS, 90050-170, Brazil., Nicoletti G; Laboratory of Cellular Physiology, Department of Physiology, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Rua Sarmento Leite, 500, 2nd floor, suite 350, Porto Alegre, RS, 90050-170, Brazil., Neto LD; Laboratory of Cellular Physiology, Department of Physiology, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Rua Sarmento Leite, 500, 2nd floor, suite 350, Porto Alegre, RS, 90050-170, Brazil., Rodrigues MI; Laboratory of Cellular Physiology, Department of Physiology, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Rua Sarmento Leite, 500, 2nd floor, suite 350, Porto Alegre, RS, 90050-170, Brazil., Bruxel MA; Laboratory of Cellular Physiology, Department of Physiology, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Rua Sarmento Leite, 500, 2nd floor, suite 350, Porto Alegre, RS, 90050-170, Brazil., Homem de Bittencourt PI Jr; Laboratory of Cellular Physiology, Department of Physiology, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Rua Sarmento Leite, 500, 2nd floor, suite 350, Porto Alegre, RS, 90050-170, Brazil. pauloivo@ufrgs.br.
المصدر: Molecular and cellular biochemistry [Mol Cell Biochem] 2016 Jan; Vol. 411 (1-2), pp. 351-62. Date of Electronic Publication: 2015 Nov 03.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Springer Country of Publication: Netherlands NLM ID: 0364456 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-4919 (Electronic) Linking ISSN: 03008177 NLM ISO Abbreviation: Mol Cell Biochem Subsets: MEDLINE
أسماء مطبوعة: Publication: New York : Springer
Original Publication: The Hague, Dr. W. Junk B. V. Publishers.
مواضيع طبية MeSH: Diet, High-Fat* , Disease Models, Animal* , Insulin Resistance*, Glutamine/*administration & dosage, Administration, Oral ; Animals ; Glutamine/analogs & derivatives ; Mice
مستخلص: In this work, we aimed to investigate the effects of long-term supplementations with L-glutamine or L-alanyl-L-glutamine in the high-fat diet (HFD)-fed B6.129SF2/J mouse model over insulin sensitivity response and signaling, oxidative stress markers, metabolism and HSP70 expression. Mice were fed in a standard low-fat diet (STA) or a HFD for 20 weeks. In the 21th week, mice from the HFD group were allocated in five groups and supplemented for additional 8 weeks with different amino acids: HFD control group (HFD-Con), HFD + dipeptide L-alanyl-L-glutamine group (HFD-Dip), HFD + L-alanine group (HFD-Ala), HFD + L-glutamine group (HFD-Gln), or the HFD + L-alanine + L-glutamine (in their free forms) group (HFD-Ala + Gln). HFD induced higher body weight, fat pad, fasted glucose, and total cholesterol in comparison with STA group. Amino acid supplementations did not induce any modifications in these parameters. Although insulin tolerance tests indicated insulin resistance in all HFD groups, amino acid supplementations did not improve insulin sensitivity in the present model. There were also no significant differences in the immunocontents of insulin receptor, Akt, and Toll-like receptor-4. Notably, total 70 kDa heat shock protein (HSP72 + HSP73) contents in the liver was markedly increased in HFD-Con group as compared to STA group, which might suggest that insulin resistance is only in the beginning. Apparently, B6.129SF2/J mice are more resistant to the harmful effects of HFD through a mechanism that may include gut adaptation, reducing the absorption of nutrients, including amino acids, which may explain the lack of improvements in our intervention.
References: Cell Stress Chaperones. 2012 May;17(3):293-302. (PMID: 22215518)
Clin Sci (Lond). 2014 May;126(10):739-52. (PMID: 24325467)
Nature. 1970 Aug 15;227(5259):680-5. (PMID: 5432063)
PLoS One. 2015 Jun 24;10(6):e0128207. (PMID: 26107628)
J Cell Biochem. 1996 May;61(2):216-29. (PMID: 9173085)
Cell Biochem Funct. 2006 Jan-Feb;24(1):23-39. (PMID: 16170839)
Front Biosci (Landmark Ed). 2011 Jan 01;16:315-39. (PMID: 21196173)
J Clin Endocrinol Metab. 2013 Jun;98(6):E1060-5. (PMID: 23633210)
Br J Nutr. 2014 Jun 28;111(12):2047-58. (PMID: 24666665)
Am J Physiol Endocrinol Metab. 2014 Mar;306(6):E668-80. (PMID: 24425764)
Clin Exp Pharmacol Physiol. 2014 Jul;41(7):482-8. (PMID: 24739055)
J Nutr Biochem. 2014 Jan;25(1):81-90. (PMID: 24314869)
J Nutr. 2009 Feb;139(2):230-7. (PMID: 19106310)
Clin Sci (Lond). 2015 Jun;128(11):789-803. (PMID: 25881670)
Regul Pept. 2010 Feb 25;160(1-3):75-80. (PMID: 19695292)
J Clin Invest. 2011 Jun;121(6):2504-17. (PMID: 21576825)
Int J Cardiol. 2011 Oct 20;152(2):218-24. (PMID: 20692055)
Curr Opin Clin Nutr Metab Care. 2014 Jul;17(4):295-305. (PMID: 24878874)
J Cell Physiol. 2005 Aug;204(2):392-401. (PMID: 15795900)
Diabetes. 2004 Dec;53 Suppl 3:S215-9. (PMID: 15561913)
Food Nutr Res. 2014 Jul 10;58:null. (PMID: 25045347)
Life Sci. 2014 Jan 17;94(2):130-6. (PMID: 24269578)
ISRN Endocrinol. 2012;2012:536905. (PMID: 22474595)
Clin Sci (Lond). 2005 Nov;109(5):447-55. (PMID: 16045439)
J Endocrinol. 2015 Mar;224(3):261-71. (PMID: 25550445)
Int J High Risk Behav Addict. 2014 Mar 10;3(1):e8725. (PMID: 24971303)
Am J Physiol Endocrinol Metab. 2011 May;300(5):E894-901. (PMID: 21325107)
Obesity (Silver Spring). 2015 Jan;23(1):120-9. (PMID: 25292174)
Nutrition. 2015 May;31(5):740-8. (PMID: 25837222)
Hepatol Res. 2014 Aug;44(8):920-34. (PMID: 23834389)
Nutrition. 2014 May;30(5):602-11. (PMID: 24698353)
Int J Sport Nutr Exerc Metab. 2015 Apr;25(2):188-97. (PMID: 25202991)
Biochem Pharmacol. 2008 Jun 15;75(12):2245-62. (PMID: 18440492)
J Proteome Res. 2015 Jan 2;14(1):353-65. (PMID: 25285821)
J Gerontol A Biol Sci Med Sci. 2012 Oct;67(10):1014-21. (PMID: 22403054)
Methods Enzymol. 1978;52:302-10. (PMID: 672633)
Diabetes. 2014 Jun;63(6):1881-94. (PMID: 24430435)
World J Diabetes. 2015 May 15;6(4):598-612. (PMID: 25987957)
Singapore Med J. 2011 Nov;52(11):779-85. (PMID: 22173246)
Anal Biochem. 1965 May;11(2):256-65. (PMID: 5840660)
Metabolism. 2010 Nov;59(11):1556-61. (PMID: 20199785)
Am J Transl Res. 2010 Jan 01;2(1):19-42. (PMID: 20182580)
Mol Metab. 2014 Aug 30;3(8):781-93. (PMID: 25379403)
Anal Biochem. 1976 May 7;72:248-54. (PMID: 942051)
PLoS One. 2014 Jan 21;9(1):e84533. (PMID: 24465415)
J Allergy Clin Immunol. 2013 Aug;132(2):287-94. (PMID: 23905917)
J Nutr. 1996 Jan;126(1):273-9. (PMID: 8558312)
Cell Biochem Funct. 2013 Apr;31(3):244-53. (PMID: 23008133)
Mediators Inflamm. 2015;2015:249205. (PMID: 25814786)
Diabetologia. 2007 Sep;50(9):1949-59. (PMID: 17604977)
Biochem Biophys Res Commun. 2010 Jan 22;391(4):1708-13. (PMID: 20043882)
Curr Opin Clin Nutr Metab Care. 2015 Jul;18(4):374-80. (PMID: 26049635)
Mol Cell Biochem. 2013 Jan;373(1-2):265-77. (PMID: 23117227)
J Nutr Biochem. 2014 Mar;25(3):345-52. (PMID: 24524905)
Nutr Res. 2013 Nov;33(11):952-60. (PMID: 24176235)
فهرسة مساهمة: Keywords: Alanyl-glutamine; Glutamine; HSP70; High-fat diet; Insulin resistance; Obesity
المشرفين على المادة: 0RH81L854J (Glutamine)
تواريخ الأحداث: Date Created: 20151105 Date Completed: 20161028 Latest Revision: 20220318
رمز التحديث: 20240628
DOI: 10.1007/s11010-015-2597-6
PMID: 26530165
قاعدة البيانات: MEDLINE
الوصف
تدمد:1573-4919
DOI:10.1007/s11010-015-2597-6