دورية أكاديمية
Relationship between Arginase 1 and Arginase 2 levels and genetic polymorphisms with erectile dysfunction.
| العنوان: | Relationship between Arginase 1 and Arginase 2 levels and genetic polymorphisms with erectile dysfunction. |
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| المؤلفون: | Lacchini R; Department of Psychiatric Nursing and Human Sciences, Ribeirao Preto College of Nursing, University of Sao Paulo, Av. Bandeirantes, 3900, 14049-900 Ribeirao Preto, SP, Brazil., Muniz JJ; Department of Psychiatric Nursing and Human Sciences, Ribeirao Preto College of Nursing, University of Sao Paulo, Av. Bandeirantes, 3900, 14049-900 Ribeirao Preto, SP, Brazil., Nobre YT; Department of Surgery and Anatomy, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Av. Bandeirantes, 3900, 14049-900 Ribeirao Preto, SP, Brazil., Cologna AJ; Department of Surgery and Anatomy, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Av. Bandeirantes, 3900, 14049-900 Ribeirao Preto, SP, Brazil., Martins AC; Department of Surgery and Anatomy, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Av. Bandeirantes, 3900, 14049-900 Ribeirao Preto, SP, Brazil., Tanus-Santos JE; Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Av. Bandeirantes, 3900, 14049-900 Ribeirao Preto, SP, Brazil. Electronic address: tanus@fmrp.usp.br. |
| المصدر: | Nitric oxide : biology and chemistry [Nitric Oxide] 2015 Dec 01; Vol. 51, pp. 36-42. Date of Electronic Publication: 2015 Nov 07. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: United States NLM ID: 9709307 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1089-8611 (Electronic) Linking ISSN: 10898603 NLM ISO Abbreviation: Nitric Oxide Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2000- > : San Diego, CA : Elsevier Original Publication: Orlando, FL : Academic Press, c1997- |
| مواضيع طبية MeSH: | Polymorphism, Genetic*, Arginase/*blood , Arginase/*genetics , Erectile Dysfunction/*enzymology , Erectile Dysfunction/*genetics, Adult ; Aged ; Aged, 80 and over ; Erectile Dysfunction/blood ; Humans ; Male ; Middle Aged ; Multivariate Analysis ; Severity of Illness Index ; Surveys and Questionnaires |
| مستخلص: | Arginase 1 and Arginase 2 are homologous enzymes that convert l-Arginine to Urea and l-ornithine and compete with nitric oxide synthases for l-Arginine. Increased Arginase 1 and 2 activity may reduce nitric oxide production by the endothelium in disease states, including erectile dysfunction (ED). Here we aimed at assessing whether Arginase 1 and 2 plasma levels, plasma arginase activity, or genetic factors are associated with ED risk and severity. Blood samples were collected from healthy controls (n = 106) and from patients with ED (n = 110) after completion of the IIEF questionnaire (international index of erectile function). Plasma Arginase 1 and 2 concentrations were assessed by ELISA, while plasma arginase activity was measured by spectrophotometry. Genotypes of ARG1 (rs2781659, rs2781667, rs2246012 and rs17599586) and ARG2 (rs3742879 and rs10483801) were determined by Taqman genotyping assays by real-time polymerase chain reaction. Increased Arginase 2 concentrations were found in clinical ED and are associated with increased risk for ED. ARG1 rs2781659 AA and rs2781667 TT genotypes are associated with lower IIEF scores (higher severity) only in clinical ED. Similarly, the ARG1 GTCC haplotype is associated with higher IIEF scores in clinical ED. This study shows that plasma Arginase 2 concentrations may serve as risk factor for ED. Besides, Arginase 1 genetic variations affect ED severity. (Copyright © 2015 Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: ARG1, ARG2; Arginase; Erectile dysfunction; Genetic polymorphisms; Nitric oxide |
| المشرفين على المادة: | EC 3.5.3.1 (ARG1 protein, human) EC 3.5.3.1 (ARG2 protein, human) EC 3.5.3.1 (Arginase) |
| تواريخ الأحداث: | Date Created: 20151106 Date Completed: 20160906 Latest Revision: 20210405 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1016/j.niox.2015.10.003 |
| PMID: | 26537638 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1089-8611 |
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| DOI: | 10.1016/j.niox.2015.10.003 |